ubtowe001

UCL staff working on ISMB
UCL staff working on ISMB
Prof. Bonnie Wallace wins the RSC Khorana Prize 2020

Prof. Bonnie Wallace wins the RSC Khorana Prize 2020

Congratulations to Professor Bonnie Ann Wallace for winning the Royal Chemical Society’s Khorana Prize 2020.

This prestigious accolade is awarded for her pioneering development of biophysical methods and bioinformatics tools to enable the characterisation of ion channel-drug molecule complexes. The Khorana Prize is the latest marker of esteem reflective of a highly successful career, as Bonnie also received the RSC Interdisciplinary Prize 2009 and the Biochemical Society’s AstraZeneca Award 2010.

Further details about the award are available here.

Posted by ubtowe001 in Achievements, Awards, News
Dr Anthony Roberts’s group determine the cryo-EM structure of the molecular motor dynein-2

Dr Anthony Roberts’s group determine the cryo-EM structure of the molecular motor dynein-2

Work from Dr Anthony Roberts’s laboratory in the ISMB, in collaboration with Dr Andrew Carter’s group at the MRC-LMB in Cambridge, has determined the cryo-EM structure of the motor protein dynein-2, which transports cargoes and signalling molecules within cilia and flagella. Dynein-2 is fundamental to human development and its dysfunction is associated with short-rib thoracic dysplasias with or without polydactyly; inherited disorders characterised by abnormal rib cage development with severe, often life-threatening, consequences.
The research – which was funded by the Wellcome Trust, Royal Society, BBSRC and MRC – is published in Nature Structural & Molecular Biology: https://www.nature.com/articles/s41594-019-0286-y
The Roberts group was recently awarded a Wellcome Trust Senior Research Fellowship to further their studies on the mechanism of transport within cilia and flagella.
Posted by ubtowe001 in Uncategorised
Two new grants awarded to Dr Giulia Zanetti’s research group

Two new grants awarded to Dr Giulia Zanetti’s research group

Dr Giulia Zanetti’s research group has been awarded two new grants.

A European Research Council (ERC) Starting Grant was awarded for a project which shows how coat assembly can deliver the flexibility necessary to accommodate a wide variety of cargo proteins, and how the process can be regulated. Her focus is on COPII coat, which mediates export from the endoplasmic reticulum (ER) of about a third of newly synthesized proteins. The aim of the project is to understand the molecular interactions between coat components and understand their role in determination of coat architecture and membrane shape.

Full details are available here.

A Biotechnology and Biological Sciences Research Council (BBSRC) grant was awarded for another project whose overall objective is to dissect the molecular mechanisms involved in COPII coat budding, and in particular to assess the dynamic regulation of the various levels of coat assembly and its role in flexible membrane remodelling.

Further details of Dr Zanetti’s research can be found on her lab website.

Posted by ubtowe001 in Uncategorised
Research symposium to be held in honour of Willie Taylor on 20th September

Research symposium to be held in honour of Willie Taylor on 20th September

Patterns in Protein Sequence and Structure (Reloaded)

This research symposium will be held at Birkbeck in honour of Willie Talyor on 20th September 2019, celebrating 40 years of his pioneering research in computational biology.

This symposium will bring together past and current collaborators and scientists inspired by Willie Taylor’s research. For those wondering about the title, this symposium also marks 30 years since the landmark conference of the same name was held at EMBL in Heidelberg, which in many respects marked the start of the modern bioinformatics era. Willie was one of the organisers of that meeting, and a number of the speakers from that conference will also be speaking in this symposium.

Full details and tickets are available here.

Posted by ubtowe001 in Uncategorised
ISMB Future Perspectives Day 2019

ISMB Future Perspectives Day 2019

On June 18th the ISMB held its inaugural Future Perspectives Day for
PhD students and PDRAs. The opening session (chaired by Snezana
Djordjevic) addressed the important issue of Open Access and the
changing landscape of research publications, and featured three
speakers with different perspectives on the subject: Nonia Pariente,
Chief Editor of Nature Microbiology; Catherine Sharp, Head of Open
Access Services, UCL Library Services; and Dalmeet Singh Chawla a
Freelance Science Journalist. The lunchtime session (chaired by Renos
Savva) on post-PhD skills in the jobs marketplace drew on expertise
from the business sector – Juliane Haupt from the Finian Group, Heidi
Kingdon Jones from IRBM and Mark Fisher from UCL Business. The
afternoon session (chaired by Adrian Shepherd) focused on the role of
AI and robotics in 21st century bioscience. Ted Meeds from Healthcare
Machine Learning at Microsoft gave a talk on the role of deep learning
in synthetic biology, Fane Mensah showed how Synthace is developing
software to facilitate the rapid design of high-throughput laboratory
experiments, and Romain Laine from the MRC Laboratory for Molecular
Cell Biology at UCL explained the ways in which machine learning is
transforming image processing in the context of advanced microscopy.

Dr Adrian Shepherd

Posted by ubtowe001 in Events, News
ISMB staff retreat 2019 at London Zoo

ISMB staff retreat 2019 at London Zoo

On a sunny day in June, just before the summer solstice, staff from the ISMB at UCL and Birkbeck had their (now) annual retreat this year at the London Zoo. In our busy lives as academics, these away-days provide us with the rare opportunity to catch up with our colleagues from across Torrington Place in a relaxed atmosphere and to make new friends!

We met at the Terrace Restaurant in the ‘Outback’, where we kick-started the day with tea and coffee, surrounded by emus and wallabies. Tabitha had expertly prepared maps that indicated our exploratory trail through the Zoo, incorporating show-and-tell and feeding times for maximum knowledge gathering and entertainment. Watching dragons, flightless birds, pigs and monkeys with moustaches and coatis – which is not pronounced like the garment (I learned that day), but rather co-ah-ti, gave people plenty to discuss over a very nice BBQ-style lunch back at the restaurant.  We then had time to continue our short trip round the zoo to catch up with some more amazing animals before listening to the two science presentations by Drs Alexa Varah and Nathalie Petorelli from the Institute of Zoology about ‘The costs of herbicide resistance in UK agriculture’ and ‘Satellite remote sensing – a conservation revolution’. Despite the fact that our research at the ISMB is somewhat remote from these topics, there was great interest from the audience and lively discussions ensued. It was a brilliant day out, and I’m looking much forward to the retreat in 2020.

Tine Arnvig, UCL-ISMB


Flightless birds


Monkey with moustache


Men in blue


See-through butterfly

Posted by ubtowe001 in Events, News, Uncategorised