Nicholas Keep

Professor of Biomolecular Science

Based at Birkbeck

Personal Website

X-ray Crystallography of Tuberculosis and Muscular Dystrophy

I am an X-ray crystallographer, who works on a wide range of collaborations on structure determination and analysis. My own research interests are in the proteins of M.tuberculosis, particularly the proteins of dormancy and peptidoglycan regulation, and in proteins involved in muscular dystrophy particularly dysferlin and its role in membrane repair in Limb Girdle Muscular Dystrophy type 2B.

Selected publications

Structure of the stationary phase survival protein YuiC from B.subtilis
Quay, D.H., Cole, A.R., Cryar, A., Thalassinos, K., Williams, M.A., Bhakta, S., Keep, N.H.
Crystal Structure of Reduced MsAcg, a Putative Nitroreductase from Mycobacterium smegmatis and a Close Homologue of Mycobacterium tuberculosis Acg
Chauviac, F.X., Bommer, M., Yan, J., Parkin, G., Daviter, T., Lowden, P., Raven, E.L., Thalassinos, K., Keep, N.H. 
Journal of Biological Chemistry (2012) 287 (53):44372-44383
Crystal structures of the human Dysferlin inner DysF domain
Sula, A., Cole, A.R., Yeats, C., Orengo, C., Keep, N.H.