News

New research, published in Cell, illuminates the molecular “trains” that transport cargoes essential for human health and development. Virtually every cell in the human body grows an antenna-like structure on its surface, which is used to receive vital signals from the body and the outside world. Perturbations in this process cause a wide range of human

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Researchers in Biological Sciences at Birkbeck, in collaboration with a group at the Peter MacCallum Cancer Centre in Melbourne, have determined the structure of a protein assembly used by the immune system to kill unwanted cells. The immune system uses cytotoxic T lymphocytes and natural killer cells to act as executioners when it detects the

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The Nobel Prize in Chemistry in 2021 has been awarded to German Benjamin List and British David MacMillan.Prof Stefan Howorka from the ISMB at UCL Chemistry explains: ‘The two researchers have developed a new class of catalysts that are inspired by Nature. Enzymes are widely used in biology as they initiate and specifically control biochemical

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Transcription is carried out by evolutionary conserved RNA polymerases and subject to regulation by different strategies. The control of individual genes is enabled by a plethora of DNA-binding transcription factors that respond to changes in the environment and enable the up- or downregulation gene expression; the structural basis and mechanisms of genespecific regulation has been

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The Wallace Group has recently received a 3-year grant from the Rosetrees Trust for work on: ‘“Seeing" General Anaesthetics Bound to Sodium Channels: Using Novel Structure/Function Information for Molecular Understanding and Design, Enabling Improved Function and Safety’ - a collaboration with Professor Hugh Hemmings’ Lab at the Weill Cornell Medical Centre in New York.

Two ISMB members - Dr Amandine Marechal and Dr Altin Sula – were invited to present talks at this year’s British Crystallographic Association (virtual) Meeting on 1 April (no foolin’). Amandine Marechal gave the Keynote Lecture, ‘Respiratory supercomplexes: what can we learn from yeast?’, in the Biological Structures group Membrane Proteins Session (chaired by Professor Bonnie Wallace),

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Dec 2020: Postdoctoral EMBO fellowships awarded to ISMB postdoc Sander Van der Verren and former ISMB PhD student Joshua Hutchings. ISMB’s Sander Van der Verren has been awarded a prestigious and highly competitive EMBO fellowship to work at ISMB in Giulia Zanetti’s laboratory. The fellowship will support structural studies of the human COPII coat complex and its

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https://www.ismb.lon.ac.uk/research-fellowship-applications/