Structural Mass Spectrometry
Our lab is interested in studying the structure and dynamics of proteins and protein complexes using a combination of mass spectrometry, ion mobility mass spectrometry and proteomics approaches. We also develop computational tools, when necessary, to process the data obtained. Current research projects involve developing methods for the study of flexible proteins, the study of protein complexes of type IV secretion systems, protein misfolding diseases such as alpha-1 antitrypsin and DNA-binding proteins involved in DNA packaging.
Selected publications
The Importance of Non-accessible Crosslinks and Solvent Accessible Surface Distance in Modeling Proteins with Restraints From Crosslinking Mass Spectrometry
Bullock, J. M. A., Schwab, J., Thalassinos, K., Topf, M.
Molecular & Cellular Proteomics (2016) 15 (7):2491-2500
Molecular & Cellular Proteomics (2016) 15 (7):2491-2500
An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of (1)-antitrypsin upon ligand binding
Nyon, M. P., Prentice, T., Day, J., Kirkpatrick, J., Sivalingam, G. N., Levy, G., Haq, I., Irving, J. A., Lomas, D. A., Christodoulou, J., Gooptu, B., Thalassinos, K.
Protein Science (2015) 24 (8):1301-1312
Protein Science (2015) 24 (8):1301-1312
Autophosphorylation Activity of a Soluble Hexameric Histidine Kinase Correlates with the Shift in Protein Conformational Equilibrium
Wojnowska, M., Yan, J., Sivalingam, G. N., Cryar, A., Gor, J., Thalassinos, K., Djordjevic, S.
Chemistry & Biology (2013) 20 (11):1411-1420
Chemistry & Biology (2013) 20 (11):1411-1420
Amphitrite: A program for processing travelling wave ion mobility mass spectrometry data
Sivalingam, G. N., Yan, J., Sahota, H., Thalassinos, K.
International Journal of Mass Spectrometry (2013) 345 ():54-62
International Journal of Mass Spectrometry (2013) 345 ():54-62