Jürg Bähler

Chair in Molecular Systems Biology


Based at UCL

Personal Website

Genome regulation and cellular ageing

We study genome regulation during cellular quiescence, ageing and stress response using fission yeast as a simple model system. We apply multiple molecular genetic, computational and genome-wide approaches for systems-level understanding of cellular processes and complex relationships between genotype, phenotype, and environment, including roles of genome evolution, energy metabolism, transcriptome regulation and non-coding RNAs.

Selected publications

Functional and regulatory profiling of energy metabolism in fission yeast
Malecki, M., Bitton, D.A., Rodriguez-Lopez, M., Rallis, C., Garcia Calavia, N., Smith, G.C., Bahler, J.
 (2016) 17( 1):240
The genomic and phenotypic diversity of Schizosaccharomyces pombe
Jeffares, D.C., Rallis, C., et al.
Nature Genetics (2015) 47 (3):235-241
Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells
Marguerat, S., Schmidt, A., Codlin, S., Chen, W., Aebersold, R., Bahler, J.
 (2012) 151 (3):671-683