Understanding molecular mechanisms and establishing functions of intracellular membrane trafficking in health and disease.
Mechanisms of fast endophilin-mediated endocytosis (FEME)
Endocytosis is the process by which cells acquire substances from the extracellular space and internalise transmembrane cell surface proteins, of which receptors are a major class. The process occurs through invaginations of the plasma membrane forming endocytic vesicles that, once pinched off the surface, are transported to endosomes and, from there, sorted to the appropriated cellular destinations depending on the fate of the receptor. We recently identified a new pathway of endocytosis, the Fast Endophilin-Mediated Endocytosis (FEME) pathway (Boucrot et al. 2015 Nature; Renard et al. 2015 Nature). Our goal is to establish the functions and molecular mechanisms of this novel route of entry into cells.
