Single-molecule biophysics and quantitative imaging
We are an experimental biophysics lab comprising a team of physicists and biologists. We create and develop state-of-the-art quantitative imaging and measurement tools and use them to determine how biological machines and systems function. The major goal of our research is to identify the principles and mechanisms by which an ensemble of molecules or cells generate particular dynamic temporal or spatial patterns, and how complex functions emerge from that organisation.
Selected publications
Cyanobacteria use micro-optics to sense light direction
Schuergers, N., Lenn, T., Kampmann, R., Meissner, M. V., Esteves, T., Temerinac-Ott, M., Korvink, J. G., Lowe, A. R., Mullineaux, C. W., Wilde, A.
eLife (2016) 5:e12620
Importin-beta modulates the permeability of the nuclear pore complex in a Ran-dependent manner
Lowe, A. R., Tang, J. H., Yassif, J., Graf, M., Huang. W., Groves, J. T., Weis, K., Liphardt, J.T.
eLife (2015) 4:e04052
Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking.
Lowe, A. R., Siegel, J.J., Kalab, P., Siu, M., Weis, K., Liphardt, J.T.
Nature (2010) 467 (7315):600-603