Computational Immunology Research Group
Our research focuses on human adaptive immune responses using a range of computational methods - from Next Generation Sequencing of immune repertoires (Rep-seq) to molecular dynamics simulations of antibody binding. We are particularly interested in applications that are close to the clinic, including vaccine design and the stratification of patient responses to therapy. We collaborate with clinicians, virologists and other wet-lab research scientists at UCL, Public Health England, Barts, the Institute of Hepatology, and beyond. Currently we are working on the adaptive immune response to several pathogens (influenza A virus, hepatitis C virus and Bacillus anthracis), to cancer (hepatocellular carcinoma and breast cancer), and to therapeutic proteins (notably Factor VIII used in the treatment of haemophilia A). This works is also driving us to develop new tools and methods, including the TRIgS toolkit (Tools for Rendering Immunoglobulin Sequences).
