Reader in Organic Chemistry and Chemical Biology
Based at UCL
Our group is primarily focused on answering important biological questions through the application of Organic Chemistry. We do this by designing and tuning a variety of chemical tools (from chemoselective reagents with orthogonal “click†handles to photoswitchable azobenzenes) for the particular system we are studying.
Selected publications
Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering
Lee, M.T.W., Maruani, A., Richards, D.A., Baker, J.R., Caddick, S., Chudasama, V.
Chemical Science (2017) 8 (3):2056-2060
Next-generation disulfide stapling: reduction and functional re-bridging all in one
Lee, M.T.W., Maruani, A., Baker, J.R., Caddick, S., Chudasama, V.
Chemical Science (2016) 7 (1):799-802
A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy
Maruani, A., Smith, M.E., Miranda, E., Chester, K.A., Chudasama, V., Caddick, S.
Nature Communications (2015) 6:6645