Molecular Bioenergetics and IR Spectroscopy Medical Diagnostics
Basic research interests are centred around biochemical and biophysical studies of biological electron transfer processes, particularly those of the mitochondrial respiratory chain, with particular emphasis on basic factors that are important for coupled electron and proton transfer in cytochrome c oxidase and quinone-reactive proteins. Primary activities are UV/visible and vibrational infrared (IR) spectroscopic techniques to study enzyme structures, kinetics and mechanisms.
These resources are also used to explore applied and translational IR applications in new medical diagnostic methods.
Selected publications
Mitochondrial Cytochrome c Oxidase: Catalysis, Coupling and Controversies
Rich, P.R.
Biochemical Society Transactions (2017) 45 (3):813-829
Functions of the hydrophilic channels in protonmotive cytochrome c oxidase
Rich, P.R., Maréchal, A.
Journal of the Royal Society Interface (2013) 10 (86):20130183
Infrared vibrational spectroscopy: a rapid and novel diagnostic and monitoring tool for cystinuria.
Oliver, K.V., Vilasi, A., Maréchal, A., Moochhala, S.H., Unwin, R.J., Rich, P.R.
Scientific Reports (2016) 6:34737