News

The prevalent state of DNA in all cells is chromatin that is made of protein-DNA complexes which are dynamic, complex and heterogenous. The exact composition of the chromatin determines its properties, how it regulates transcription and genome architecture. A breakthrough article by the RNAP laboratory at UCL published today in the journal Nature Communications describes
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Finn Werner's group published a paper in Nature Communications on 22nd February. The paper studies the mechanism of how viruses enter and replicate in the hosts cells is of fundamental importance to understand how they cause disease and developing tools for control. A team of scientists at UCL, led by Prof Finn Werner, have taken a major
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Together with the Topf lab at the Centre for Structural Systems Biology (Hamburg), Kish Adoni from the Thalassinos lab has developed a novel pipeline that incorporates crosslinking-mass spectrometry data into AlphaFold2 for improved accuracy of protein structure determination. They found this workflow to be of particular relevance to proteins that occupy multiple conformations. The function
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Professor Helen Saibil's research group published a paper titled 'Structural basis of substrate progression through the bacterialchaperonin cycle' in the PNAS Journal on 23 October 2023. The full paper is available here.

Professor Sanjib Bhakta (School of Natural Sciences, Faculty of Science, Birkbeck) and his research lab has been featured in the The Royal Society of Biology's magazine, The Biologist. Full article can be accessed here.

Dr Joseph Ng and Prof. Franca Fraternali have published the novel method sciCSR to analyse CSR (class-switch recombination) and the antibody response by using molecular data from single B-cells (Nature Methods).  sciCSR allows researchers to analyse in high detail how CSR occurs across time. By building mathematical models to infer CSR events probabilistically, sciCSR can be applied in scenarios including vaccination and gene knockouts and to
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Flemming Hansen’s research group published a paper titled ‘Intrinsic structural dynamics dictate enzymatic activity and inhibition’ in the Proceedings of the National Academy of Sciences (PNAS) Journal on 2 October 2023. The full paper is available here.