Matilda Katan

Professor of Protein Biochemistry

Based at UCL

Personal Website

Signal transduction in disease: application of multidisciplinary approaches

Research activity covers several areas of signal transduction in the context of disease development and treatment with the theme of "Signalling via Phospholipid-derived Second Messengers in Cancer" being of primary focus for a number of years; our seminal contributions to knowledge (described in Cell 54:171 and Nature 380: 595) were in this field.

Current research topics include several key cell-signalling components: phosphoinosite-signalling enzymes (PLC), tyrosine kinase receptors (FGFR) and novel enzymes involved in posttranslational modifications (AMPylation), using multidisciplinary approaches that span from structural and synthetic biology to animal models and imaging.

Importantly, dysregulation of these cellular components has been linked to a number of diseases, notably, to different types of cancer and to immune disorders where changes affecting immune cells directly can also have indirect consequences for development of other diseases such as dementia. Therefore, we are also moving this fundamental research forward towards drug discovery.

Selected publications

Dysfunction of phospholipase Cγ in immune disorders and cancer
Koss, H., Bunney, T.D., Behjati, S., Katan, M.
Trends in Biochemical Sciences (2014) 39 (12):603-611
Tumor suppressor role of phospholipase C epsilon in Ras-triggered cancers
Martins, M., McCarthy, A., Baxendale, R., Guichard, S., Magno, L., Kessaris, N., El-Bahrawy, M., Yu, P., Katan, M.
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2
Bunney, T.D., Opaleye, O., Roe, S.M., Vatter, P., Baxendale, R.W., Walliser, C., Everett, K.L., Josephs, M.B., Christow, C., Rodrigues-Lima, F., Gierschik, P., Pearl, L.H., Katan, M.
Molecular Cell (2009) 34 (2):223-233