Jamie Baker

Reader in Chemical Biology


Based at UCL

Personal Website

Chemical Biology and Targeted Therapeutics

Our group is highly interdisciplinary, working at the boundary between organic synthesis, biology and medicine. Ongoing projects include; the development of new classes of reagents for protein modification; the construction of homogeneous antibody conjugates as targeted therapeutics and diagnostics; the design of albumin bioconjugates for drug delivery; exploring new photo-triggered chemical reactions; and the development of photoactive probes for controlling ion channel activity.

Selected publications

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis
Morais, M., Nunes, J. P. M., Karu, K., Forte, N., Benni, I., Smith, M. E. B., Caddick, S., Chudasama, V., Baker, J. R.
Organic & Biomolecular Chemistry (2017) 15:2947-2952

Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines
Richards, D. A., Fletcher, S. A., Nobles, M., Kossen, H., Tedaldi, L., Chudasama, V., Tinker, A., Baker, J. R.
Organic & Biomolecular Chemistry (2015) 14:455-459

Photo-antagonism of the GABA(A) receptor
Mortensen, M., Iqbal, F., Pandurangan, A. P., Hannan, S., Huckvale, R., Topf, M., Baker, J. R., Smart, T. G.
Nature Communications (2014) 5:4454