We want to understand how proteins and nucleic acids come together to create detailed and responsive networks and regulate the flow of information in the cell. Research topics include the key RNA synthesis and translation (and degradation) machineries but also the less conserved complexes essential to the mRNA transport, as well as the system-wide genetic code variations modulating protein structure/function. We use structural, computational and cellular techniques to provide a mechanistic view of how individual molecules and molecular ensembles control physiological (e.g. in neuronal development) and pathological (e.g.) in infection and cancer) processes in human.