Dr Joseph Ng and Prof. Franca Fraternali have published the novel method sciCSR to analyse CSR (class-switch recombination) and the antibody response by using molecular data from single B-cells (Nature Methods).
sciCSR allows researchers to analyse in high detail how CSR occurs across time. By building mathematical models to infer CSR events probabilistically, sciCSR can be applied in scenarios including vaccination and gene knockouts and to predict how antibody responses are mounted against immune challenges.