The ISMB Biophysics Centre provides access to instrumentation and expertise in the characterisation of biological macromolecules and their interactions, under the academic lead of Dr Mark Williams and with Centre Manager Dr Tina Daviter.

A variety of instrumentation is available for the characterisation of equilibrium and kinetic behaviours of protein, nucleic acid and small-molecule interactions on a hire, service or collaborative basis, including:

Analytic ultracentrifugation (AUC)
Circular dichroism
– UV/Vis spectrometry
Fluorescence spectrometry
Isothermal titration calorimetry (ITC)
Differential scanning calorimetry (DSC)
Differential scanning fluorimetry (thermal melts)
Stopped-Flow and Quench-Flow kinetic analysis
Biolayer interferometry
– Dynamic light scattering
Size-exclusion chromatography with multi-angle light scattering (SEC-MALS)

Researchers interested in using these technologies should contact Dr Tina Daviter.

Trained users can book instruments though our online booking system.

In addition, the Molecular Interactions Facility at UCL provides access to instruments for analytic ultracentrifugation, small angle x-ray and neutron scattering, surface plasmon resonance, and dual polarisation interferometry.