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ISMB Member Publications 2010


Dr Jim Anderson [top]

Anderson, J. C., Bou-moreno, R. (2010). The efficient synthesis of carbodiimides using a titanium imido complex. Tetrahedron 66(47), 9182-9186 doi:10.1016/j.tet.2010.09.073.

Anderson, J. C., Davies, E. A. (2010). Diastereoselective synthesis of substituted prolines via 5-endo-trig cyclisations of aza-[2,3]-Wittig sigmatropic rearrangement products. Tetrahedron 66(33), 6300-6308


Dr Erik Arstad [top]

Garcia-arguello, S. F., Arstad, E., Brickute, D., Luthra, S. K., Turton, D. R., Glaser, M., Fortt, R., Robins, E. G. (2010). Automated synthesis of [11C]-(+)-PHNO from [11C]methyl iodide. Neuroimage. ( Vol. 52 pp.S218-S218). Academic press Inc Elsevier Science.

Robins, E. G., Zhao, Y. J., Khan, I., Wilson, A., Luthra, S. K., Arstad, E. (2010). Synthesis and in vitro evaluation of F-18-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET. Bioorg Med Chem Lett 20(5), 1749-1751

Dr James Baker [top]

Baker, J. R., Hothersall, J. D., Fitzmaurice, R. J., Tucknott, M., Vinter, A., Tinker, A., Caddick, S. (2010). An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity. Chem Commun (Camb) 46(22), 3953-3954

Smith, M., Caddick, S., Baker, J. R., Waksman, G., Schumacher, F., Papaiannou, D., Tedaldi, L., Ryan, C. (2010). Protein modification, bioconjugation, and disulfide bridging using bromomaleimides. Journal of the American Chemical Society (132), 1960-1965

Dr Tracey Barrett [top]

Dr Sanjib Bhakta [top]


Basavannacharya, C.; Moody, P. R.; Munshi, T.; Cronin, N.; Keep, N. H. and Bhakta, S. (2010) Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis. Protein & Cell 1(10): 73-84 (cover page story).

Guzman, J-D.; Gupta, A.; Evangelopoulos, D.; Basavannacharya, C.; Pabon, L.C.; Plazas, E.A.; Muñoz, D.R.; Delgado, W.A.; Cuca, L.E.; Ribon, W.; Gibbons, S. and Bhakta, S. (2010) Anti-tubercular screening of natural products from Colombian plants: 3-5 methoxy nordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis. J. Antimicrob. Chemotherapy 65(10), 2101-7.

Basavannacharya, C.; Robertson, G.; Munshi, T.; Keep, N. H. and Bhakta, S. (2010) ATP-dependent MurE ligase in Mycobacterium tuberculosis: Biochemical and structural characterisation. Tuberculosis (Elsevier) 90(1):16-24.

Westwood I.M.†, Bhakta, S. †, Russell, A.J. †, Fullam, E., Anderton, M.C., Akane Kawamura, A., Mulvaney, A.W., Vickers, R.J., Bhowruth, V., Besra, G.S., Lalvani, A., Davies, S.G. and Sim, E. († equal first authors) (2010) Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars. Protein & Cell 1(1): 82-95

Dr Emmanuel Boucrot [top]

Boucrot E., Saffarian S., Zhang R.Y. and Kirchhausen T. (2010)  ‘Roles of AP-2 during clathrin-mediated endocytosis'  PLoS One  5(5):e10597     joint first authors
 
Henne W.M., Boucrot E., Meinecke M., Evergren E., Vallis Y., Mittal R., and McMahon H.T. (2010) ‘FCHo proteins are nucleators of clathrin-mediated endocytosis'  Science  328(5983):1281-4
    
Dumont A., Boucrot E., Drevensek S., Daire V., Gorvel J.P., Poüs C., Holden D.W. and Méresse S. (2010) 'SKIP, the host target of the Salmonella virulence factor SifA, promotes kinesin-1 dependent vacuolar membrane exchanges' Traffic  11(7):899-911
 
Thiery J., Keefe D., Saffarian S., Martinvalet D., Walch M., Boucrot E., Kirchhausen T. and Lieberman J. (2010) 'Perforin activates clathrin and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis' Blood  115(8):1582-93

Dr Kate Bowers [top]

Lawrence, S. P., Bright, N. A., Luzio, J. P., Bowers, K. (2010). The sodium/proton exchanger NHE8 regulates late endosomal morphology and function. Mol Biol Cell 21(20), 3540-3551


Professor Jeremy Brockes [top]

Blassberg, R. A., Garza-garcia, A., Janmohamed, A., Gates, P. B., Brockes, J. P. (2010). Functional convergence of signalling by GPI-anchored and anchorless forms of a salamander protein implicated in limb regeneration. J Cell Sci. 2011 Jan 1;124(Pt 1):47-56.

Garza-garcia, A. A., Driscoll, P. C., Brockes, J. P. (2010). Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders. Integrative and Comparative Biology  50, 528-535

Godwin, J. W., Liem, K. F., Brockes, J. P. (2010). Tissue factor expression in newt iris coincides with thrombin activation and lens regeneration.  Mech Dev 127(7-8), 321-328

Kumar, A., Nevill, G., Brockes, J. P., Forge, A. (2010). A comparative study of gland cells implicated in the nerve dependence of salamander limb regeneration.  J Anat 217(1), 16-25

Professor Steve Caddick [top]

Baker, J. R., Hothersall, J. D., Fitzmaurice, R. J., Tucknott, M., Vinter, A., Tinker, A., Caddick, S. (2010). An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity. Chem Commun (Camb) 46(22), 3953-3954

Chudasama, V., Fitzmaurice, R. J., Ahern, J. M., Caddick, S. (2010). Dioxygen mediated hydroacylation of vinyl sulfonates and sulfones on water. Chem Commun 46(1), 133-135

Chudasama, V., Fitzmaurice, R. J., Caddick, S. (2010). Hydroacylation of alpha,beta-unsaturated esters via aerobic C-H activation. Nat Chem 2(7), 592-596

Loh, B., Vozzolo, L., Mok, B. J., Lee, C. C., Fitzmaurice, R. J., Caddick, S., Fassati, A. (2010). Inhibition of HIV-1 Replication by Isoxazolidine and Isoxazole Sulfonamides. Chem Biol Drug Des 75(5), 461-474

Smith, M., Caddick, S., Baker, J. R., Waksman, G., Schumacher, F., Papaiannou, D., Tedaldi, L., Ryan, C. (2010). Protein modification, bioconjugation, and disulfide bridging using bromomaleimides. Journal of the American Chemical Society (132), 1960-1965

Wu, L., Aliev, A. E., Caddick, S., Fitzmaurice, R. J., Tocher, D. A., King, F. D. (2010). A facile synthesis of dibenzopyrroloazepinones as tetracyclic allocolchicinoids - an unusual 1,2-phenyl shift. Chemical Communications 46, 318-320


Professor Richard Catlow [top]

Adriaens, D. A., Goumans, T. P. M., Catlow, C. R. A., Brown, W. A. (2010). Computational study of carbonyl sulphide formation on model interstellar dust grains. The Journal of Physical Chemistry C 114, 1892-1900


Dr John Christodoulou [top]

Transient tertiary structure formation within the ribosome exit port. (2010) O'Brien EP, Hsu ST, Christodoulou J, Vendruscolo M, Dobson CM. (2010) J Am Chem Soc. 2010 Dec 1;132(47):16928-37.

Structure and properties of a complex of α-synuclein and a single-domain camelid antibody. (2010) De Genst EJ, Guilliams T, Wellens J, O'Day EM, Waudby CA, Meehan S, Dumoulin M, Hsu ST, Cremades N, Verschueren KH, Pardon E, Wyns L, Steyaert J, Christodoulou J, Dobson CM. J Mol Biol. 2010 Sep 17;402(2):326-43.

A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis. (2010) Hagan CL, Johnson RJ, Dhulesia A, Dumoulin M, Dumont J, De Genst E, Christodoulou J, Robinson CV, Dobson CM, Kumita JR. Protein Eng Des Sel. 2010 Jul;23(7):499-506.

The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation. (2010) Waudby CA, Knowles TP, Devlin GL, Skepper JN, Ecroyd H, Carver JA, Welland ME, Christodoulou J, Dobson CM, Meehan S. Biophys J. 2010 Mar 3;98(5):843-51.

Protein folding on the ribosome. (2010) Cabrita LD, Dobson CM, Christodoulou J. Curr Opin Struct Biol. 2010 Feb;20(1):33-45. Review.

Professor Peter Coveney [top]

Anderson, R. L., Ratcliffe, I., Greenwell, H. C., Williams, P. A., Cliffe, S., Coveney, P. V. (2010). Clay swelling - A challenge in the oilfield. Earth-Sci Rev 98(3-4), 201-216

Annett, J. F., Coveney, P. V. (2010). Special section: CompSci07, Computational Science 2007: Interdisciplinary challenges and perspectives, from the Grid to e-Science. Future Gener Comp Sy 26(3), 504-505

Cooper, J., Cervenansky, F., De Fabritiis, G., Fenner, J., Friboulet, D., Giorgino, T., Manos, S., Martelli, Y., Villa-freixa, J., Zasada, S., Lloyd, S., Mccormack, K., Coveney, P. V. (2010). The Virtual Physiological Human TOOLKIT. Philosophical Transactions of the Royal Society A-Mathematical Physical and Engineering Sciences. ( Vol. 368 pp.3925-3936).

Coveney, P. V., Giupponi, G., Jha, S., Manos, S., Maclaren, J., Pickles, S. M., Saksena, R. S., Soddemann, T., Suter, J. L., Thyveetil, M., Zasada, S. J. (2010). Large scale computational science on federated international grids: The role of switched optical networks. Future Gener Comp Sy 26(1), 99-110

Doctors, G. M., Mazzeo, M. D., Coveney, P. V. (2010). A computationally efficient method for simulating fluid flow in elastic pipes in three dimensions. Comput Phys Commun 181(9), 1584-1592

Hewer, T. D., Nekovee, M., Coveney, P. V. (2010). Reducing Congestion in Obstructed Highways with Traffic Data Dissemination Using Ad hoc Vehicular Networks. Eurasip J Adv Sig Pr , 169503

Hunter, P., Coveney, P. V., De Bono, B., Diaz, V., Fenner, J., Frangi, A. F., Harris, P., Hose, R., Kohl, P., Lawford, P., Mccormack, K., Mendes, M., Omholt, S., Quarteroni, A., Skar, J., Tegner, J., Thomas, S. R., Tollis, I., Tsamardinos, I., Van Beek, J. H. G. M., Viceconti, M. (2010). A vision and strategy for the virtual physiological human in 2010 and beyond.

Mazzeo, M. D., Manos, S., Coveney, P. V. (2010). In situ ray tracing and computational steering for interactive blood flow simulation. Comput Phys Commun 181(2), 355-370

Sadiq, S. K., Wright, D. W., Kenway, O. A., Coveney, P. V. (2010). Accurate ensemble molecular dynamics binding free energy ranking of multidrug-resistant HIV-1 proteases.  J Chem Inf Model 50(5), 890-905

Saksena, R. S., Mazzeo, M. D., Zasada, S. J., Coveney, P. V. (2010). Petascale lattice-Boltzmann studies of amphiphilic cubic liquid crystalline materials in a globally distributed high-performance computing and visualization environment. Philos Transact A Math Phys Eng Sci 368(1925), 3983-3999

Swadling, J. B., Coveney, P. V., Greenwell, H. C. (2010). Clay minerals mediate folding and regioselective interactions of RNA: a large-scale atomistic simulation study. J Am Chem Soc 132(39), 13750-13764

Swadling, J. B., Coveney, P. V., Greenwell, H. C. (2010). Computer simulation study of the interaction of RNA with montmorillonite clay. Geochimica et Cosmochimica Acta. ( Vol. 74 pp.A1012-A1012). PERGAMON-ELSEVIER SCIENCE LTD.

Dr Martin Crompton [top]



Prof Chris Danpure [top]


Djordjevic, S., Zhang, X., Bartlam, M., Ye, S., Rao, Z., Danpure, C. J. (2010). Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting. Acta Crystallogr Sect F Struct Biol Cryst Commun 66(Pt 3), 233-236


Dr Snezana Djordjevic [top]

Djordjevic, S., Zhang, X., Bartlam, M., Ye, S., Rao, Z., Danpure, C. J. (2010). Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting. Acta Crystallogr Sect F Struct Biol Cryst Commun 66(Pt 3), 233-236

Jarvis, A., Allerston, C. K., Jia, H., Herzog, B., Garza-garcia, A., Winfield, N., Ellard, K., Aqil, R., Lynch, R., Chapman, C., Hartzoulakis, B., Nally, J., Stewart, M., Cheng, L., Menon, M., Tickner, M., Djordjevic, S., Driscoll, P. C., Zachary, I., Selwood, D. L. (2010). Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem 53(5), 2215-2226

Patel, S., Hussain, S., Harris, R., Sardiwal, S., Kelly, J. M., Wilkinson, S. R., Driscoll, P. C., Djordjevic, S. (2010). Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I). Biochem J 425(3), 513-522

Sardiwal, S., Santini, J. M., Osborne, T. H., Djordjevic, S. (2010). Characterization of a two-component signal transduction system that controls arsenite oxidation in the chemolithoautotroph NT-26. FEMS Microbiol Lett. 313(1):20-8.

Dr Paul Driscoll [top]


Professor Jasminka Godovac-Zimmerman [top]


Radulovic, M., Godovac-zimmermann, J. (2011). Proteomic approaches to understanding the role of the cytoskeleton in host-defense mechanisms. Expert Rev Proteomics. 2011 Feb;8(1):117-26.

Godovac-zimmermann, J. (2010). Cancer-omics failure: Warehouses, Magic Bullets, Space/Time and The Life of Brian in a Cancer Cell. Expert Review of Proteomics 7, 303-306

Mulvey, C., Thur, B., Crawford, M., Godovac-zimmermann, J. (2010). How many proteins are missed in quantitative proteomics based on MS/MS sequencing methods?. Proteomics Insights 3, 61-66

Mulvey, C., Tudzarova, S., Crawford, M., Williams, G. H., Stoeber, K., Godovac-zimmermann, J. (2010). Quantitative proteomics reveals a "poised quiescence" cellular state after triggering the DNA replication origin activation checkpoint. J Proteome Res 9(10), 5445-5460

Qattan, A., Mulvey, C., Crawford, M., Natale, D. A., Godovac-zimmermann, J. (2010). Quantitative Organelle Proteomics of MCF-7 Breast Cancer Cells reveals Multiple Subcellular Locations for Proteins in Cellular Functional Processes, on line. Journal of Proteome Research 9, 495-508

Radulovic, M., Crane, E., Crawford, M., Godovac-zimmermann, J. Y., V, P. C. C. (2010). Cks proteins protect mitochondrial genome integrity by interacting with mitochondrial single-stranded DNA binding protein. Molecular and Cellular Proteomics 9, 145-152

Tudzarova, S., Trotter, M. W. B., Wollenschlager, A., Mulvey, C., Godovac-zimmermann, J., Williams, G., Stoeber, K. (2010). Molecular Architecture of the DNA Replicatuon Origin Activation Checkpoint. EMBO J 29, 3381-3394

Dr Bibek Gooptu [top]


Ekeowa UI, Freeke J, Miranda E, Gooptu B, Bush MF, Pérez J, Teckman J, Robinson CV, Lomas DA. (2010) Defining the mechanism of polymerization in the serpinopathies. Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40):17146-51.

Miranda E, Pérez J, Ekeowa UI, Hadzic N, Kalsheker N, Gooptu B, Portmann B, Belorgey D, Hill M, Chambers S, Teckman J, Alexander GJ, Marciniak SJ, Lomas DA. (2010) A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency. Hepatology. 2010 Sep;52(3):1078-88.


Dr Ivan Gout [top]


Breus, O., Panasyuk, G., Gout, I. T., Filonenko, V., Nemazanyy, I. (2010). CoA Synthase is phosphorylated on tyrosines in mammalian cells, interacts with and is dephosphorylated by Shp2PTP. Mol Cell Biochem 335(1-2), 195-202.

Fenton, T. R., Gwalter, J., Cramer, R., Gout, I. T. (2010). S6K1 is acetylated at lysine 516 in response to growth factor stimulation. Biochem Biophys Res Commun 398(3), 400-405.

Fenton, T. R., Gwalter, J., Ericsson, J., Gout, I. T. (2010). Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo. Int J Biochem Cell Biol 42(2), 359-366.

Gnjatic, S., Cao, Y., Reichelt, U., Yekebas, E. F., Nolker, C., Marx, A. H., Erbersdobler, A., Nishikawa, H., Hildebrandt, Y., Bartels, K., Horn, C., Stahl, T., Gout, I., Filonenko, V., Ling, K. L., Cerundolo, V., Luetkens, T., Ritter, G., Friedrichs, K., Leuwer, R., Hegewisch-becker, S., Izbicki, J. R., Bokemeyer, C., Old, L. J., Atanackovic, D. (2010). NY-CO-58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer. Int.J.Cancer 127(2), 381-393

Goh, E. T., Pardo, O. E., Michael, N., Niewiarowski, A., Totty, N., Volkova, D., Tsaneva, I. R., Seckl, M. J., Gout, I. (2010). Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway. J.Biol.Chem. 285(22), 17065-17076

Gorbenko, O., Panayotou, G., Zhyvoloup, A., Volkova, D., Gout, I., Filonenko, V. (2010). Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4. Mol.Cell Biochem. 337(1-2), 299-305

Kiyamova, R., Kostianets, O., Malyuchik, S., Filonenko, V., Usenko, V., Gurtovyy, V., Khozayenko, Y., Antonuk, S., Old, L., Gout, I. (2010). Identification of Tumor-Associated Antigens from Medullary Breast Carcinoma by a Modified SEREX Approach. Mol.Biotechnol. 2010 Oct;46(2):105-12.

Dr Helen Hailes [top]

Cázares, A., Galman, J. L., Crago, L. G., Smith, M. E., Strafford, J., Ríos-solís, L., Lye, G. J., Dalby, P. A., Hailes, H. C. (2010). Non-alpha-hydroxylated aldehydes with evolved transketolase enzymes. Org Biomol Chem 8(6), 1301-1309.

Chiva, A., Williams, D. E., Tabor, A. B., Hailes, H. C. (2010). Screening of polymeric supports and enzymes for the development of an endo enzyme cleavable linker. Tetrahedron Lett 51(20), 2720-2723.

Galman, J. L., Steadman, D., Bacon, S., Morris, P., Smith, M. E., Ward, J. M., Dalby, P. A., Hailes, H. C. (2010). α,α'-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes. Chem Commun (Camb) 46(40), 7608-7610.

Greco, E., Aliev, A. E., Lafitte, V. G. H., Bala, K., Duncan, D., Pilon, L., Golding, P., Hailes, H. C. (2010). Cytosine modules in quadruple hydrogen bonded arrays. NEW J CHEM 34(11), 2634-2642.

Grosse, S. M., Tagalakis, A. D., Mustapa, M. F., Elbs, M., Meng, Q. H., Mohammadi, A., Tabor, A. B., Hailes, H. C., Hart, S. L. (2010). Tumor-specific gene transfer with receptor-mediated nanocomplexes modified by polyethylene glycol shielding and endosomally cleavable lipid and peptide linkers.. FASEB J 24(7), 2301-2313.

Hailes, H. C., Dalby, P. A., Lye, G. J., Baganz, F., Micheletti, M., Szita, N., Ward, J. M. (2010). α α'-Dihydroxy Ketones and 2-Amino-1,3-diols: Synthetic and Process Strategies using Biocatalysts. Current Organic Chemistry , 1883-1893 [Submitted]

Smith, M. E. B., Chen, B. H., Hibbert, E. G., Kaulmann, U., Smithies, K., Galman, J. L., Baganz, F., Dalby, P. A., Hailes, H. C., Lye, G. J., Ward, J. M., Woodley, J. M., Micheletti, M. (2010). A Multi-Disciplinary Approach Toward the Rapid and Preparative Scale Biocatalytic Synthesis of Chiral Amino Alcohols: A Concise Transketolase /ω -Transaminase-Mediated Synthesis of (2S,3S)-2-Aminopentane-1,3-diol. Organic Process Research & Development 14, 99-107 [Submitted]

Smith, M. E. B., Gunn, R. M., Rosivatz, E., Mak, L. H., Woscholski, R., Hailes, H. C. (2010). Development of chemical probes: Toward the mode of action of a methylene-linked di(aryl acetate) E1. Bioorgan Med Chem 18(14), 4917-4927

Smith, M., Chen, B., Hibbert, E., Kaulmann, U., Smithies, K., Galman, J., Baganz, F., Dalby, P., Hailes, H., Lye, G., Ward, J., Woodley, J., Micheletti, M. (2010). A multi-disciplinary approach toward the rapid and preparative scale biocatalytic synthesis of chiral amino alcohols: a concise transketolase/ω-transaminase-mediated synthesis of (2S,3S)-2-aminopentane-1,3-diol. Organic Process Research and Development 14, 99-107


Professor Elizabeth Hounsell [top]


Dr Richard Hayward [top]


No better time to FRET: shedding light on host pathogen interactions. (2010) Hayward RD, Goguen JD, Leong JM. J Biol. 2010;9(2):12. Epub 2010 Feb 18. Review.

Dr Stefan Howorka [top]

Caruana, D. J., Howorka, S. (2010). Biosensors and biofuel cells with engineered proteins. MOL BIOSYST 6(9), 1548-1556.

Kinns, H., Badelt-lichtblau, H., Egelseer, E. M., Sleytr, U. B., Howorka, S. (2010). Identifying Assembly-Inhibiting and Assembly-Tolerant Sites in the SbsB S-Layer Protein from Geobacillus stearothermophilus. Journal of Molecular Biology 395, 742-753.

Kukwikila, M., Howorka, S. (2010). Electrically sensing protease activity with nanopores. J PHYS-CONDENS MAT 22(45), 454103.

Leung, C., Maradan, D., Kramer, A., Howorka, S., Mesquida, P., Hoogenboom, B. W. (2010). Improved Kelvin probe force microscopy for imaging individual DNA molecules on insulating surfaces. APPL PHYS LETT 97(20), 203703.

Mitchell, N., Howorka, S. (2010). Chemical Tags Mediate the Orthogonal Self-Assembly of DNA Duplexes into Supramolecular Structures. Small 6(16), 1732-1735.

Winroth, G., Fenwick, O., Scott, M. A., Yip, D., Howorka, S., Cacialli, F. (2010). Interfacial dipole dynamics of light-emitting diodes incorporating a poly(amidoamine) dendrimer monolayer. APPL PHYS LETT 97(4), 043304

Zhu, R., Howorka, S., Pröll, J., Kienberger, F., Preiner, J., Hesse, J., Ebner, A., Pastushenko, V. P., Gruber, H. J., Hinterdorfer, P. (2010). Nanomechanical recognition measurements of individual DNA molecules reveal epigenetic methylation patterns. Nat Nanotechnol 5(11), 788-791

Zhu, R., Howorka, S., Proll, J., Kienberger, F., Preiner, J., Hesse, J., Ebner, A., Pastushenko, V. P., Gruber, H. J., Hinterdorfer, P. (2010). Nanomechanical recognition measurements of individual DNA molecules reveal epigenetic methylation patterns. Nat Nanotechnol 5(11), 788-791.

Ziwy, S., Howorka, S. (2010). Engineered Voltage-Responsive Nanopores. Chemical Society Reviews 39(3), 1115-1132


Professor David Jones [top]

Buchan, D.W., Ward, S.M., Lobley, A.E., Nugent, T.C., Bryson, K. & Jones, D.T. (2010) Protein annotation and modelling servers at University College London. Nucl. Acids Res. 38 Suppl, W563-W568.

Nugent, T. & Jones, D.T. (2010) Predicting transmembrane helix packing arrangements using residue contacts and a force-directed algorithm. Plos Comput. Biol.l. Biol. 6, e1000714604.

Pentony, M.M., Ward, J. & Jones, D.T. (2010) Computational resources for the prediction and analysis of native disorder in proteins. Methods Mol. Biol. 604, 369-393.

Pentony, M. & Jones, D.T. (2010) Modularity of intrinsic disorder in the human proteome. Proteins. 78, 212-221.


Dr Christopher Kay [top]

Grohmann, D., Klose, D., Klare, J. P., Kay, C. W., Steinhoff, H. J., Werner, F. (2010). RNA-binding to archaeal RNA polymerase subunits F/E: a DEER and FRET study. J Am Chem Soc 132(17), 5954-5955

Menzel, R., Tran, M. Q., Menner, A., Kay, C. W. M., Bismarck, A., Shaffer, M. S. P. (2010). A versatile, solvent-free methodology for the functionalisation of carbon nanotubes. Chem Sci 1(5), 603-608

Morley GW, Warner M, Stoneham AM, Greenland PT, van Tol J, Kay CW, Aeppli G. (2010) The initialization and manipulation of quantum information stored in silicon by bismuth dopants. Nat Mater. 2010 Sep;9(9):725-9.

Pauwels, E., Declerck, R., Verstraelen, T., De Sterck, B., Kay, C. W. M., Van Speybroeck, V., Waroquier, M. (2010). Influence of Protein Environment on the Electron Paramagnetic Resonance Properties of Flavoprotein Radicals: A QM/MM Study. J Phys Chem B 114(49), 16655-16665


Dr Nick Keep [top]

Basavannacharya, C., Robertson, G., Munshi, T., Keep, N.H. & Bhakta, S. (2010). ATP-dependent MurE ligase in Mycobacterium tuberculosis: Biochemical and structural characterisation. Tuberculosis 90, 16-24.

Basavannacharya, C.; Moody, P. R.; Munshi, T.; Cronin, N.; Keep, N. H. and Bhakta, S. (2010) Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis. Protein & Cell 1(10): 73-84 (cover page story).


Dr Philip Lowden [top]

Comprehensive Behavioral Testing in the R6/2 Mouse Model of Huntington's Disease Shows No Benefit from CoQ10 or Minocycline Menalled, L.B., Patry, M., Ragland, N., Lowden, P.A.S., Goodman, J., Minnich, J., Zahasky, B., Park, L., Leeds, J., Howland, D., Signer, E., Tobin, A.J., Brunner, D.
PLoS One 2010, Vol. 5, Iss. 3, Article No. e9793 DOI: 10.1371/journal.pone.0009793

 

Dr Derek MacMillan [top]

Ackrill, T., Anderson, D. W., Macmillan, D. (2010). Towards biomolecular assembly employing extended native chemical ligation in combination with thioester synthesis using an N-->S acyl shift. Biopolymers 94(4), 495-503.

De Cecco, M., Seo, E. S., Clarke, D. J., Mccullough, B. J., Taylor, K., Macmillan, D., Dorin, J. R., Campopiano, D. J., Barran, P. E. (2010). Conformational Preferences of Linear beta-Defensins Are Revealed by Ion Mobility-Mass Spectrometry. J Phys Chem B 114(6), 2312-2318.

Kang, J., Macmillan, D. (2010). Peptide and protein thioester synthesis via N-->S acyl transfer.. Org Biomol Chem 8(9), 1993-2002.

Masania, J., Li, J., Smerdon, S. J., Macmillan, D. (2010). Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N→S acyl transfer. Org Biomol Chem 8(22), 5113-5119.

Mccullough, B. J., Kalapothakis, J. M., Chin, W., Taylor, K., Clarke, D. J., Eastwood, H., Campopiano, D., Macmillan, D., Dorin, J., Barran, P. E. (2010). Binding a heparin derived disaccharide to defensin inspired peptides: insights to antimicrobial inhibition from gas-phase measurements. Phys Chem Chem Phys 12(14), 3589-3596.

Reynolds, N. L., Cecco, M. D., Taylor, K., Stanton, C., Kilanowski, F., Kalapothakis, J., Seo, E., Uhrin, D., Campopiano, D., Govan, J., Macmillan, D., Barran, P., Dorin, J. R. (2010). Peptide Fragments of a ß-Defensin Derivative With Potent Bactericidal Activity. Antimicrobial Agents and Chemotherapy 54(5), 1922-1929.

Reynolds, N. L., De Cecco, M., Taylor, K., Stanton, C., Kilanowski, F., Kalapothakis, J., Seo, E., Uhrin, D., Campopiano, D., Govan, J., Macmillan, D., Barran, P., Dorin, J. R. (2010). Peptide fragments of a beta-defensin derivative with potent bactericidal activity. Antimicrob Agents Chemother 54(5), 1922-1929.

Richardson, J. P., Chan, C. H., Blanc, J., Saadi, M., Macmillan, D. (2010). Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N-->S acyl transfer. Org Biomol Chem 8(6), 1351-1360

Tyrrell, C., De Cecco, M., Reynolds, N. L., Kilanowski, F., Campopiano, D., Barran, P., Macmillan, D., Dorin, J. R. (2010). Isoleucine/leucine(2) is essential for chemoattractant activity of beta-defensin Defb14 through chemokine receptor 6. Mol Immunol 47(6), 1378-1382

Virdee, S., Macmillan, D., Waksman, G. (2010). Semisynthetic Src SH2 Domains Demonstrate Altered Phosphopeptide Specificity Induced by Incorporation of Unnatural Lysine Derivatives. Chemistry & Biology 17(3), 274-284

Professor Charles Marson [top]

Assem, E. S. K., Mann, S., Wan, B. Y. C., Marson, C. M. (2010). Effect of antioxidants on airway smooth muscle contraction: action of lipoic acid and some of its novel derivatives on guinea pig tracheal smooth muscle. Inflamm Res 59, 235-237.

Wan, B. Y. C., Mann, S., Assem, E. S. K., Marson, C. M. (2010). Effect of endogenous and synthetic antioxidants on hydrogen peroxide-induced guinea-pig colon contraction. Inflamm Res 59, 231-233

Dr Andrew Martin [top]

Nan R, Farabella I, Schumacher FF, Miller A, Gor J, Martin AC, Jones DT, Lengyel I, Perkins SJ. (2011) Zinc Binding to the Tyr402 and His402 Allotypes of Complement Factor H: Possible Implications for Age-Related Macular Degeneration. J Mol Biol. 2011 Mar 16. [Epub ahead of print]

Martin AC, Besag FM, Berry DJ, Besag FP. (2011) The effect of lamotrigine on valproic acid concentrations. Curr Drug Saf. 2011 Feb 1;6(1):23-9.

Abhinandan, K. R., Martin, A. C. R. (2010). Analysis and prediction of V-H/V-L packing in antibodies. Protein Eng Des Sel 23(9), 689-697

Baresic, A., Hopcroft, L. E. M., Rogers, H. H., Hurst, J. M., Martin, A. C. R. (2010). Compensated Pathogenic Deviations: Analysis of Structural Effects. J Mol Biol 396(1), 19-30.

Hirtreiter, A., Damsma, G. E., Cheung, A. C., Klose, D., Grohmann, D., Vojnic, E., Martin, A. C., Cramer, P., Werner, F. (2010). Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif. Nucleic Acids Res 38(12), 4040-4051

Thullier, P., Huish, O., Pelat, T., Martin, A. C. R. (2010). The Humanness of Macaque Antibody Sequences. J Mol Biol 396(5), 1439-1450

Dr Nigel Martin [top]


Zamboulis L. , Martin N., Poulovassilis A.(2010) Query Performance Evaluation of an Architecture for Fine-Grained Integration of Heterogeneous Grid Data Sources. Future Generation Computer Systems 26(8), 1073-1091 (2010)


Dr Neil McDonald [top]

Kjær S, Hanrahan S, Totty N & McDonald NQ. (2010) Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Nature Structural and Molecular Biology (2010) 17: 726-731

Mologni L, Rostagno R, Brussolo S, Knowles PP, Kjaer S, Murray-Rust J, Rosso E, Zambon A, Scapozza L, McDonald NQ, Lucchini V, Gambacorti-Passerini C (2010).Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1482-96

Dr Adam MacKay [top]



Professor Boris Mirkin [top]


Dr Carolyn Moores [top]

Fourniol, F.J., Sindelar, C.V., Amigues, B., Clare, D.K., Perderiset, M., Francis, F., Houdusse, A., and Moores, C.A. (2010) Template-free 13-protofilament microtubule-MAP assembly visualized at 8Å resolution. J. Cell Biol. 191, 463-470.

Peters, C., Brejc, K., Belmont, L., Bodey, A., Lee, Y., Yu, M., Guo, J., Sakowicz, R., Hartman, J., and Moores, C.A. (2010) Insight into the molecular mechanism of the multi-tasking kinesin-8 motor. EMBO J. 29, 3437-3447.

Moores C.A. (2010). Kinesin-5 mitotic motors: Is loop5 the on/off switch? Cell Cycle. 9, 1234.

Fourniol F. and Moores C.A. (2010). Kinesin motor activation: Microtubules pull the switches. Proc. Natl. Acad. Sci. U.S.A. 107, 3949-50.


Professor David Moss [top]

A computational analysis of the antigenic properties of haemagglutinin in influenza A H3N2. Lees W, Moss D and Shepherd A, Bioinformatics, (2010). doi: 10.1093/bioinformatics/btq160

Dr Sylvia Nagl [top]


Dr Irilenia Nobeli [top]


Professor Christine Orengo [top]

Reid, A., Ranea, J.A. & Orengo, C. (2010). CODA: Accurate detection of functional associations by domain fusion in higher eukaryoytes. PLoS One 5 (6):e 10908.

Reid, A., Ranea, J.A. & Orengo, C. (2010). Comparative Evolutionary Analysis of Complexes in E.Coli and Yeast. BMC Genomics. 11, 79.

Ranea, J.A., Reid, A., Yeats, C. & Orengo, C.A. (2010) Study of the Dark Matter in Protein Network Prediction and Modelling. PLoS Comp. Biol. 6(9). pii: e1000945.

Yeats C, Redfern OC, Orengo C. (2010) A fast and automated solution for accurately resolving protein domain architectures. Bioinformatics. 26(6):745-51.

Lee DA, Rentzsch R, Orengo C. (2010) GeMMA: functional subfamily classification within superfamilies of predicted protein structural domains. Nucleic Acids Res. 38(3):720-37.

Lees J, Yeats C, Redfern O, Clegg A, Orengo C. (2010) Gene3D:merging structure and function for a Thousand genomes.  Nucleic Acids Res. 38:D296-300.

Morilla I, Lees J.G., Reid A.J., Orengo C, Ranea J.A. (2010) Assessment of protein domain fusions in human protein interaction networks prediction: application to the human kinetochore model. N Biotechnol. 27(6):755-65.

Perkins J.R., Diboun I, Dessailly B.H, Lees J.G, Orengo C. (2010) Transient protein-protein interactions: structural, functional, and network properties. Structure. 18(10):1233-43.

Dessailly B.H, Redfern O.C, Cuff A.L, Orengo C.A. (2010) Detailed analysis of function divergence in a large and diverse domain superfamily: toward a refined protocol of function classification. Structure. 18(11):1522-35.


Dr Elena Orlova [top]

Clare DK, Orlova EV. 4.6A Cryo-EM reconstruction of tobacco mosaic virus from images recorded at 300keV on a 4kx4k CCD camera. (2010) J Struct Biol. 171, 303-308

Dr Andrew Osborne [top]


The host targeting motif in exported Plasmodium proteins is cleaved in the parasite endoplasmic reticulum. Osborne AR, Speicher KD, Tamez PA, Bhattacharjee S, Speicher DW, Haldar K. Mol Biochem Parasitol. 2010 May;171(1):25-31. Epub 2010 Feb 1. PMID: 20117149  doi:10.1016/j.molbiopara.2010.01.003

A role for the two-helix finger of the SecA ATPase in protein translocation. Erlandson KJ, Miller SB, Nam Y, Osborne AR, Zimmer J, Rapoport TA. Nature. 2008 Oct 16;455(7215):984-7. PMID: 18923526  doi:10.1038/nature07439

Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation. Erlandson KJ, Or E, Osborne AR, Rapoport TA.
J Biol Chem. 2008 Jun 6;283(23):15709-15. Epub 2008 Mar 21.
PMID: 18359943
doi: 10.1074/jbc.M710356200



Professor Steve Perkins [top]

Okemefuna, A. I., Stach, L., Rana, S., Ziai Buetas, A. J., Gor, J. & Perkins, S. J. (2010). C-reactive protein exists in an NaCl concentration dependent pentamer-decamer equilibrium in physiological buffer. J. Biol. Chem. 285, 1041-1052.  Pubmed 19903811

Okemefuna, A. I., Nan, R., Miller, A. Gor, J. & Perkins, S. J. (2010) Complement Factor H binds at two independent sites to C-reactive protein in acute-phase concentrations. J. Biol. Chem. 285, 1053-1065. "Selected as a Journal of Biological Chemistry (JBC) Paper of the Week: in the top 1% of papers published. Selected for front cover." Pubmed 19850925

Khan, S., Gor, J., Mulloy, B. & Perkins, S. J. (2010). Semi-rigid solution structures of heparin by constrained X-ray scattering modelling: new insight into heparin-protein complexes. J. Mol. Biol. 395, 504-521. Pubmed 19895822.

Hebecker, M., Okemefuna, A. I., Perkins, S. J., Mihlan, M. & Józsi, M. (2010). Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4. Molec. Immunol. 47, 1347-1355. Pubmed 20042240.

Johnson, S. A., Williams, J. M., Hakobyan, S., Richards, A., Perkins, S. J., Marchbank, K. J., Goodship, T. H. J., Morgan, B. P., Taylor, C. M. & Savage, C. O. S. (2010). Impact of compound heterozygous complement factor H mutations on development of atypical hemolytic uremic syndrome - a pedigree revisited. Molec. Immunol. 47, 1585-1591. Pubmed 20304497.

Leonard, P. G., Parkinson, G. N., Gor, J., Perkins, S. J. & Ladbury, J. E. (2010). The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein. Acta Cryst. F66, 421-466. Pubmed 20383013.

Niewiarowski, A., Bradley, A. S., Gor, J., McKay, A. R., Perkins, S. J. & Tsaneva, I. R. (2010). Oligomeric assembly and interactions within human RuvBL1 and RuvBL2 complexes. Biochem. J. 429, 113-125. Pubmed 20412048

Perkins, S. J., Okemefuna, A. I., & Nan, R. (2010). Invited review. Unravelling protein-protein interactions between complement factor H and C-reactive protein by a multidisciplinary strategy. Biochem. Soc. Transact. 38, 894-900. Pubmed 20658973.

Tchepeleva, S. N., Thurman, J. M., Ruff, K., Perkins, S. J., Morel, L. & Boackle, S. A. (2010). An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation. J. Immunol. 185, 2331-2339. Pubmed 20660348.

Perkins, S. J., Nan, R., Okemefuna, A. I., Li, K., Khan, S. & Miller, A. (2010). Invited review. Multiple interactions of complement factor H with its ligands in solution: a progress report. Current Topics on Complement and Eye Diseases (Ed. J.D. Lambris and A. Adamis). Adv. Exp. Med. Biol. 703, 25-47. Pubmed 20711705.

Li, K., Gor, J. & Perkins, S. J. (2010). Self-association and domain rearrangements between complement C3 and C3u provide insight into the activation mechanism of C3. Biochem. J. 431, 63-72. Pubmed 20666732.

Abe, Y., Gor, J., Bracewell, D. G., Perkins, S. J. & Dalby, P. A. (2010). Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy. Biochem. J. 432, 101-111. Pubmed 20722630.


Dr Saul Purton [top]


Santabarbara S, Kuprov I, Pulektov O, Casal A, Russell CA, Purton S, Evans MCW (2010). Directionality of electron transfer reactions in Photosystem I of prokaryotes: universality of the bidirectional electron transfer model. J. Phys. Chem. B. 114: 15158-15171.

DOI: 10.1021/jp1044018


Professor Peter Rich [top]

Rich, P.R. and Maréchal. A. (2010) The mitochondrial respiratory chain. Essays in Biochemistry, 27, 1-23.

Murphy, E.J., Maréchal, A., Segal, A.W. and Rich, P.R. [2010] CO binding and ligand discrimination in human myeloperoxidase, Biochemistry, 49, 2150-2158.


Professor David Saggerson [top]


Professor Helen Saibil [top]

Law, RHP, Lukoyanova, N, Voskoboinik, I, Caradoc-Davies, TT, Baran, K, Dunstone, MA, D’Angelo, ME, Orlova, EV, Coulibaly, F, Verschoor, S, Browne, KA, Ciccone, A, Kuiper, MJ, Bird, PI, Trapani, JA, Saibil, HR & Whisstock, JC (2010) The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature 468, 447-451.

Dr Joanne Santini [top]

Sardiwal, S., Santini, JM., Osborne, TH & Djordjevic, S. (2010). Characterization of a two-component signal transduction system that controls arsenite oxidation in the chemolithoautotroph NT-26. FEMS Microbiology Letters. 313(1) 20-28.

Osborne, T.H., Jamieson, H.E., Hudson-Edwards, K.A., Nordstrom, D.K., Walker, S.R., Ward, S.A., Santini, J.M. (2010). Microbial oxidation of arsenite in a subartic environment: Diversity of arsenite oxidase genes and identification of a psychrotolerant arsenite oxidiser.  BMC Microbiology. 10(205).

Duval, S., Santini, J.M., Nitschke, W., Hille, R., and Schoepp-Cothenet, B. (2010).  The small subunit AroB of arsenite oxidase: lessons on the [2Fe-2S]-Rieske protein superfamily. J Biol Chem. 285(27) 20442-20451. 

Lowe EC, Bydder S, Hartshorne RS, Tape HL, Dridge EJ, Debieux CM, Paszkiewicz K, Singleton I, Lewis RJ, Santini JM, Richardson DJ, Butler CS. (2010). Quinol-cytochrome c oxidoreductase and cytochrome c4 mediate electron transfer during selenate respiration in Thauera selenatis. J Biol Chem. 285(24) 18433-42


Dr Renos Savva [top]


Dr David Selwood [top]


Professor Elizabeth Shephard [top]

Shephard EA, Phillips IR (2010). The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism.. Expert Opin Drug Metab Toxicol, 6(9), 1083 - 1094. doi:10.1517/17425255.2010.503705

Dr Adrian Shepherd [top]

Lees, W., Moss, D.S., Shepherd, A.J. (2010). A Computational Analysis of the Antigenic Properties of Haemagglutinin in Influenza A H3N2. Bioinformatics 26(11):1403-1408 doi: 10.1093/bioinformatics/btq160

Garcia-Alcade, F., Blanco, A., Shepherd, A.J. (2010). An intuitionistic approach to scoring DNA sequences against transcription factor binding site motifs. BMC Bioinformatics 11:551 doi: 10.1186/1471-2105-11-551

Halling-Brown, M., Pappalardo, F., Rapin, N., Zhang, P., Alemani, D., Emerson, A., Castiglione, F., Duroux, P., Pennisi, M., Miotto, O., Churchill, D., Rossi, E., Moss, D.S., Sansom, C.E., Bernaschi, M., Lefranc, M.P., Brunak, S., Lund, O., Motta, S., Lollini, P.L., Murgo, A., Palladini, A., Basford, K.E., Brusic, V., Shepherd, A.J. (2010).  ImmunoGrid: Towards Agent-based Simulations of the Human Immune System at a Natural Scale. Philosophical Transactions of the Royal Society A   368:2799-2815 doi: 10.1098/rsta.2010.0067

Dr Christine Slingsby [top]

Explosive expansion of gamma-crystallin genes in the ancestral vertebrate. Kappe, G., Purkiss, A.G., van Genesen, S.T., Slingsby, C. and Lubsen, N.H. (2010) J. Mol. Evol. 71:219-230.  DOI: 10.1007/s00239-010-9379-2


Dr Alona Sosinsky [top]


Prof Kaila Srai [top]

Srai SK, Chung B, Marks J, Pourvali K, Solanky N, Rapisarda C, Chaston TB, Hanif R, Unwin RJ, Debnam ES, Sharp PA. Erythropoietin regulates intestinal iron
absorption in a rat model of chronic renal failure. Kidney Int. 2010 Oct;78(7):660-7.


Dr Alethea Tabor [top]

Raiber, E. A., Tulone, C., Zhang, Y., Martinez-Pomares, L., Steed, E., Sponaas, A. M., Langhorne, J., Noursadeghi, M., Chain, B. M., Tabor, A. B. (2010). A General Approach for Receptor and Antibody-Targeted Detection of Native Proteins Utilizing Split-Luciferase Reassembly. ACS Chem Biol 5(5), 461-476.

Grosse, S. M., Tagalakis, A. D., Mustapa, M. F., Elbs, M., Meng, Q. H., Mohammadi, A., Tabor, A. B., Hailes, H. C., Hart, S. L. (2010). Tumor-specific gene transfer with receptor-mediated nanocomplexes modified by polyethylene glycol shielding and endosomally cleavable lipid and peptide linkers.  FASEB J 24(7), 2301-2313. 
 
Chaudhry, B. R., Wilton-Ely, J. D. E. T., Tabor, A. B., Caruana, D. J. (2010). Effect of peptide orientation on electron transfer. Phys Chem Chem Phys 12(34), 9996-9998.

Chiva, A., Williams, D. E., Tabor, A. B., Hailes, H. C. (2010). Screening of polymeric supports and enzymes for the development of an endo enzyme cleavable linker. Tetrahedron Lett 51(20), 2720-2723.  

Körner, C., Raiber, E. A., Keegan, S. E. M., Nicolau, D. C., Sheppard, T. D., Tabor, A. B. (2010). An expedient synthesis of orthogonally protected lysinoalanine from Aloc-protected Garner's aldehyde. Tetrahedron Lett 51(49), 6381-6383.


Dr Konstantinos Thalassinos [top]

Walldén, K., Williams, R., Yan, J., Lian, P.W., Wang, L., Thalassinos, K., Orlova, E.V. and Waksman, G. Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system Proceedings of the National Academy of Sciences (2012) 109:11348–11353.

Nyon, M.P, Segu, L., Cabrita, L.D., Lévy, G.R., Kirkpatrick, J., Roussel, B.D., Patschull, A.O.M., Barrett, T.E., Ekeowa, U.I., Kerr, R., Waudby, C.A., Kalsheker, N., Hill, M., Thalassinos, K., Lomas, D.A., Christodoulou, J. and Gooptu, B. Structural Dynamics Associated with Intermediate Formation in an Archetypal Conformational Disease Structure (2012) 20:504–512.

Malet, H., Canellas, F., Sawa, J., Yan, J., Thalassinos, K., Ehrmann, M., Clausen, T. and Saibil, H.R. Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ Nature Structural & Molecular Biology (2012) 19:152–157.

Chang, Y.P., Mahadeva, R., Patschull, A.O.M. Nobeli, I., Ekeowa, U.I., McKay, A.R., Thalassinos, K., Irving, J.A., Haq, I., Nyon, M.P., Christodoulou, J., Ordóñez, A., Miranda, E. and Gooptu. B. Targeting Serpins in High-Throughput and Structure-Based Drug Design (Chapter 8)
Methods in Enzymology (2011) 501:139–175.

Harvey, D.J., Sobott, F., Crispin, M., Wrobel, A., Bonomelli, C.,Vasiljevic, S., Scanlan, C.N., Scarff, C.A., Thalassinos, K. and Scrivens
J.H. Ion Mobility Mass Spectrometry for Extracting Spectra of N-Glycans Directly from Incubation Mixtures Following Glycan Release: Application to Glycans from Engineered Glycoforms of Intact, Folded HIV gp120 Journal of the American Society for Mass Spectrometry (2011) 22:568-581.

Wyttenbach, T., Grabenauer, M., Thalassinos, K., Scrivens, J. H. and Bowers, M. T. The Effect of Calcium Ions and Peptide Ligands on the Relative Stabilities of the Calmodulin Dumbbell and Compact Structures Journal of Physical Chemistry B (2010) 114:437-447.

Jackson, A. T., Thalassinos, K., John, R. O., McGuire, N., Freeman, D. and Scrivens, J. H. Characterisation of end groups in poly(2-hydroxyethyl methacrylate) by means of electrospray ionisation-mass spectrometry/mass spectrometry (ESI-MS/MS) Polymer (2010) 51:1418-1424.

Hilton, G. R.†, Thalassinos, K.†, Grabenauer, M., Sanghera, N., Slade, S.E., Wyttenbach, T., Robinson, P. J., Pinheiro, T. J. T., Bowers, M. T. and Scrivens, J. H. † joint first authors Structural Analysis of Prion Proteins by Means of Drift Cell and Traveling Wave Ion Mobility Mass Spectrometry Journal of the American Society for Mass Spectrometry (2010) 21:845-854.


Dr Geraint Thomas [top]



Dr Katherine Thompson [top]

Thompson, KC, Rennie, AR, King, MD, Hardman, SJO, Lucas, COM, Pfrang, C, Hughes, BR and Hughes, AV, (2010) Reaction of a Phospholipid Monolayer with Gas-Phase Ozone at the Air−Water Interface: Measurement of Surface Excess and Surface Pressure in Real Time, Langmuir, 26(22), 17295–17303.

King, MD, Rennie, AR, Pfrang, C, Hughes AV and Thompson, KC, (2010) Interaction of nitrogen dioxide (NO2) with a monolayer of oleic acid at the air–water interface – A simple proxy for atmospheric aerosol, Atmospheric Environment, 44, 1822–1825


Dr Salvador Tomas [top]

Mutual modulation between membrane-embedded receptor clustering and ligand binding in lipid membranes. Authors (corresponding author(s) noted with an asterisk (*)): S. Tomas*, L. Milanesi . Nature Chemistry. 2010, 2, 1077-1083  DOI: 10.1038/NCHEM.892


Dr Maya Topf [top]

Zhang S, Vasishtan D, Xu M, Topf M*, Alber F*. A fast mathematical programming procedure for simultaneous fitting of assembly components into cryo-EM density maps. (2010)  Bioinformatics 26:i261-i268.  (*equal corresponding authorship). doi:10.1093/bioinformatics/btq201

Rawi R, Whitmore L, Topf M. CHOYCE – A web server for constrained homology modelling with cryoEM maps. (2010) Bioinformatics 26:1673-4.  doi:10.1093/bioinformatics/btq237

Malet H, Topf M, Clare DK, Ebert J , Bonneau F, Basquin J, Drazkowska K, Tomecki R, Dziembowski A, Conti E, Saibil HR, Lorentzen E. (2010)  RNA channelling by the eukaryotic exosome. EMBO Rep 11:936-942. Cover.

Kumar RA, Pilz DT, Babatz TD, Cushion T, Harvey K, Topf M, Uyanik G, Rees MI, Harvey RJ, Dobyns WB. (2010) TUBA1A mutations cause wide spectrum lissencephaly (smooth brain) and suggest that multiple neuronal migration pathways converge on alpha tubulins. Hum Mol Genet 19:2817-2827.

Rawi R, Whitmore L, Topf M. (2010) CHOYCE – A web server for constrained homology modelling with cryoEM maps. Bioinformatics 26:1673-4.

Zhang S, Vasishtan D, Xu M, Topf M*, Alber F* (2010) A fast mathematical programming procedure for simultaneous fitting of assembly components into cryo-EM density maps. (*equal contribution). Bioinformatics [ISMB] 26:i261-i268.

Yuan S, Yu X, Topf M, Ludtke SJ, Wang X, Akey CW. (2010) Structure of the human apoptosome with prodomains of procaspase-9. Structure 18:571-583.

Gartmann M, Blau M, Armache JP, Mielke T, Topf M, Beckmann R (2010) Mechanism of eIF6-mediated inhibition of ribosomal subunit joining. J Biol Chem 285:14848-14851.


Dr Andrea Townsend-Nicholson [top]

Eddaoudi, A and Townsend-Nicholson, A and Timms, JF and Schorge, S and Jayasinghe, SN (2010) Molecular characterisation of post-bio-electrosprayed human brain astrocytoma cells. ANALYST , 135 (10) 2600 - 2612. DOI 10.1039/c0an00213e.


Dr Irina Tsaneva [top]

Niewiarowski A, Bradley AS, Gor J, McKay AR, Perkins SJ, Tsaneva IR. Oligomeric assembly and interactions within the human RuvB-like RuvBL1 and RuvBL2 complexes. Biochem J. 2010 Jul 1;429(1):113-25. PubMed PMID: 20412048.

Dr Cara Vaughan [top]


Understanding of the Hsp90 molecular chaperone reaches new heights. Vaughan CK, Neckers L, Piper PW. Nat Struct Mol Biol. 2010 Dec;17(12):1400-4. 


Professor Gabriel Waksman [top]

Biochemical dissection of the ATPase TraB, the VirB4 homologue of the Escherichia coli pKM101 conjugation machinery.
Durand E, Oomen C, Waksman G.


Professor Bonnie Wallace [top]

Powl, A.M., O’Reilly, A.O., Miles, A.J. and Wallace, B.A. (2010) Synchrotron radiation circular dichroism spectroscopy-defined structure of the C-terminal domain of NaChBac and its role in channel assembly. Proc. Natl. Acad. Sci. USA, 107: 14064-14069.

Prof John Ward [top]

Hailes HC, Dalby PA, Lye GJ, Baganz F, Micheletti M, Szita N, Ward JM. (2010). α α'-Dihydroxy Ketones and 2-Amino-1,3-diols: Synthetic and Process Strategies using Biocatalysts. Current Organic Chemistry. 14. 1883-1893

Ward J, and Wohlgemuth R. (2010) High-Yield Biocatalytic Amination Reactions in Organic Synthesis. Current Organic Chemistry. 14. 1928-1965

Dr Finn Werner [top]


J Am Chem Soc. 2010 May 5;132(17):5954-5. Impact 9.0 RNA-binding to archaeal RNA polymerase subunits F/E: a DEER and FRET study. Grohmann D, Klose D, Klare JP, Kay CW, Steinhoff HJ, Werner F.

Nucleic Acids Res. 2010 Jul;38(12):4040-51. Impact 7.8 Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif.
Hirtreiter A, Damsma GE, Cheung AC, Klose D, Grohmann D, Vojnic E, Martin AC, Cramer P, Werner F.

Nucleic Acids Res. 2010 Jan;38(2):585-96. Impact 7.8
Molecular mechanisms of RNA polymerase--the F/E (RPB4/7) complex is required for high processivity in vitro. Hirtreiter A, Grohmann D, Werner F.
 
Dr Lorenz Wernisch [top]


Dr Jonathan Wilden [top]


Dr Mark Williams [top]


Dr Steve Wood [top]


Dr Xuemei Yuan [top]




 





 
 
   
     
Institute of Structural Molecular Biology, University of London
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