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ISMB member publications in 2006



Dr Erik Arstad [top]

Smith G, Glaser M, Perumal M, Nguyen QD, Shan B, Årstad E, Aboagye EO (2008) Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide (2008). J Med Chem. 51(24), 8057-67.

Glaser M, Solbakken M, Turton DR, Pettitt R, Barnett J, Arukwe J, Karlsen H, Cuthbertson A, Luthra SK, Årstad E (2008). Methods for 18F-labeling of RGD peptides: comparison of aminooxy [18F]fluorobenzaldehyde condensation with 'click labeling' using 2-[18F]fluoroethylazide, and S-alkylation with [18F]fluoropropanethiol., Amino Acids, Nov 15. [Epub ahead of print]

 

Dr James Baker [top]

N/A

 

Dr Tracey Barrett [top]

"Bagnéris C, Ageichik AV, Cronin N, Wallace B, Collins M, Boshoff C, Waksman G, Barrett T. (2008) Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome. Mol Cell. 30(5):620-31.


Dr Sanjib Bhakta [top]



O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S. (2008) Bioactive Pyridine-N-oxide Disulfides from Allium stipitatum. J Nat Prod. 72(3):360-365.

Sim E, Sandy J, Evangelopoulos D, Fullam E, Bhakta S, Westwood I, Krylova A, Lack N, Noble M. (2008) Arylamine N-acetyltransferases in mycobacteria. Curr Drug Metab. 9(6):510-9.

Dr Kate Bowers [top]

Su,Y.,Blake-Palmer,K.G.,Sorrell,S.,Javid,B.,Bowers,K.,Zhou,A.,Chang,S.H.,Qamar,S.,Karet,F.E., (2008). Human H+ATPase a4 subunit mutations causing renal tubular acidosis reveal a role for interaction with phosphofructokinase-1. American Journal of Physiology - Renal Physiology.

Zhai,C.,Li,K.,Markaki,V.,Phelan,J.P.,Bowers,K.,Cooke,F.T.,Panaretou,B., (2008). Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane. Biochemical Journal


Professor Jeremy Brockes [top]

Brockes,J.P., Kumar,A. (2008). Comparative aspects of animal regeneration. Annual Review of Cell and Developmental Biology 24, 525-549.


Professor Steve Caddick [top]

Trindade,A.F., Gois,P.M.P., Veiros,L.F., Andre,V., Duarte,M.T., Afonso,C.A.M., Caddick,S., Cloke,F.G.N. (2008). Axial coordination of NHC ligands on dirhodium(II) complexes: Generation of a new family of catalysts. Journal of Organic Chemistry, 73 (11), 4076-4086

Cawley,M.J., Cloke,F.G.N., Fitzmaurice,R.J., Pearson,S.E., Scott,J.S., Caddick,S.D., (2008). Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst. Organic & Biomolecular Chemistry, 6 (15), 2820-2825

Esposito,O., Gois,P.M.P., Lewis,A.K.D.K., Caddick,S., Cloke,F.G.N., Hitchcock,P.B. (2008). Alkylpalladium N-Heterocyclic Carbene Complexes: Synthesis, Reactivity, and Catalytic Properties. Organometallics, 27 (24), 6411-6418


Professor Richard Catlow [top]


Catlow,C.R.A., Bell,R.G., Slater,B., Woodley,S.M. (2008). Modelling of Structures of Heterogeneous Catalysts. in Ertl,G., Knözinger,H., Schüth,F., Weitkamp,J. (ed.) Handbook of Heterogeneous Catalysis. Weinheim: Wiley-VCH, 2nd edition.

Goumans,T.P.M., Catlow,C.R.A., Brown,W.A (2008). Hydrogenation of CO on a silica surface: an embedded cluster approach. Journal of Chemical Physics 128(13), 134709.

Goumans,T.P.M., Catlow,C.R.A., Brown,W.A. (2008). Catalysis of addition reactions by a negatively charged silica surface site on a dust grain. Journal of Physical Chemistry C 112(39), 15419-15422.

Shevlin,S.A., Guo,Z.X., van Dam,H.J.J., Sherwood,P., Catlow,C.R.A., Sokol,A.A., Woodley,S.M. (2008). Strucutre,Optical Properties and Defects in Nitride (III-V) nanoscale cage clusters. Physical Chemistry Chemical Physics 10, 1944-1959.

Wilson,E.L., Grau-Crespo,R., Pang,C.L., Cabailh,G., Chen,Q., Purton,J.A., Catlow,C.R.A., Brown,W.A., de Leeuw,N.H., Thornton,G. (2008). Redox behaviour of the model catalyst Pd/CeO2-x/Pt(111) Journal of Physical Chemistry C 112, 10918-10922.


Dr John Christodoulou [top]


Baldwin AJ, Anthony-Cahill SJ, Knowles TP, Lippens G, Christodoulou J, Barker PD, Dobson CM. (2008). Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution-state NMR diffusion measurements. Angew. Chemie 47(18), 3385-3387

Gsponer,J.A., Christodoulou,J., Cavalli,A., Dobson,C.M., Vendruscolo,M., (2008). A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction. Structure .

Rivers,R.C., Kumita,J.R., Tartaglia,G.G., Dedmon. M.M., Pawar,A., Vendruscolo,M., Dobson,C.M., Christodoulou,J., (2008). Molecular determinants of the aggregation of alpha-synuclein and beta-synuclein. Protein Science.

Roodveldt C, Christodoulou J, Dobson CM. (2008) Immunological features of alpha-synuclein in Parkinson's disease. J Cell Mol Med. 2008 Oct;12(5B):1820-9. Epub 2008 Jul 30. Review. Erratum in: J Cell Mol Med. 2008 Dec;12(6B):2875.

Huang, J-R., Hsu, S-T.D., Christodoulou, J., Jackson, S.E., HFSP Journal., (2008) The extremely slow-exchanging core and acid-denatured state of green fluorescent protein HFSP Journal. 2, 378-387.

Chan PH, Pardon E, Menzer L, De Genst E, Kumita JR, Christodoulou J, Saerens D, Brans A, Bouillenne F, Archer DB, Robinson CV, Muyldermans S, Matagne A, Redfield C, Wyns L, Dobson CM, Dumoulin M. (2008) Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils. Biochemistry. 2008 Oct 21;47(42):11041-54. Epub 2008 Sep 25.


Professor Peter Coveney [top]


De Fabritiis,G., Geroult,S., Coveney,P.V., Waksman,G. (2008). Insights from the energetics of water binding at the domain-ligand interface of the Src SH2 domain. Proteins: Structure, Function, and Genetics 72(4), 1290-1297.

Sadiq,K.S., Mazzeo,M.D., Zasada,S.J., Manos,S., Stoica,I., Gale,C.V., Watson,S.J., Kellam,P., Brew,S. and Coveney,P.V. (2008). Patient-specific simulation as a basis for clinical decision-making. Philos Transact A Math Phys Eng Sci 366(1878), 3199-3219

I. Stoica, S. K. Sadiq, P. V. Coveney (2008) Rapid and Accurate Prediction of Binding Free Energies for Saquinavir-Bound HIV-1 Proteases. Journal of the American Chemical Society, 130, (8), 2639-2648.

M. Thyveetil, P. V. Coveney, H. C. Greenwell, J. Suter (2008). Computer Simulation Study of the Structural Stability and Materials Properties of DNA-Intercalated Layered Double Hydroxides. Journal of the American Chemical Society.

Wan S, Flower DR, Coveney PV.(2008) Toward an atomistic understanding of the immune synapse: large-scale molecular dynamics simulation of a membrane-embedded TCR-pMHC-CD4 complex. Mol Immunol. 2008 Mar;45(5):1221-30.

Scott DJ, Manos S, Coveney PV, Rossiny JC, Fearn S, Kilner JA, Pullar RC, Alford NM, Axelsson AK, Zhang Y, Chen L, Yang S, Evans JR, Sebastian MT.(2008) Functional ceramic materials database: an online resource for materials research. J Chem Inf Model. 2008 Feb;48(2):449-55.

Saksena RS, Coveney PV. (2008) Self-assembly of ternary cubic, hexagonal, and lamellar mesophases using the lattice-Boltzmann kinetic method. J Phys Chem B. 2008 Mar 13;112(10):2950-7.

Thyveetil MA, Coveney PV, Greenwell HC, Suter JL. (2008) Role of host layer flexibility in DNA guest intercalation revealed by computer simulation of layered nanomaterials. J Am Chem Soc. 2008 Sep 17;130(37):12485-95. .


Dr Martin Crompton [top]


Gillick,K., Crompton,M. (2008). Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release. J Cell Sci. 2008 Mar 1;121(Pt 5):618-26.


Prof Chris Danpure [top]


N/A


Dr Snezana Djordjevic [top]


Parkinson,G.N., Vines,D., Driscoll,P.C., Djordjevic,S. (2008). Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding. BMC Structural Biology 8, 13

S. Djordjevic, T. Barrett, J. Pitts, C. Slingsby, D. Moss, C. Sansom and N. Keep (2008). The web-based teaching in the Institute of Structural and Molecular Biology, University of London. Acta Cryst. (2008). A64, C80.


Dr Paul Driscoll [top]

Garza-Garcia,A., Esposito,D., Rieping,W., Harris,R., Briggs,C., Brown,M.H., Driscoll,P.C. (2008). Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5. Journal of Molecular Biology 378(1), 129-144.

Parkinson,G.N., Vines,D., Driscoll,P.C., Djordjevic,S. (2008). Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding. BMC Structural Biology 8, 13.

Patel,D.S., Garza-Garcia,A., Nanji,M., McElwee,J.J., Ackerman,D., Driscoll,P.C., Gems,D. (2008). Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor. Genetics 178(2), 931-946.

Patel,P., Harris,R., Geddes,S.M., Strehle,E.M., Watson,J.D., Bashir,R., Bushby,K., Driscoll,P.C., Keep,N.H. (2008). Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b. Journal of Molecular Biology 379(5), 981-990.

Professor Jasminka Godovac-Zimmerman [top]

N/A

Dr Bibek Gooptu [top]


Gooptu B, Lomas DA. (2008) Polymers and inflammation: disease mechanisms of the serpinopathies. J Exp Med. 205(7):1529-34. Review.

Dr Ivan Gout [top]


Wang ML, Panasyuk G, Gwalter J, Nemazanyy I, Fenton T, Filonenko V, Gout I. (2008) Regulation of ribosomal protein S6 kinases by ubiquitination. Biochem Biophys Res Commun. 2008 May 2;369(2):382-7.


Dr Helen Hailes [top]

Hibbert,E.G., Senussi,T., Smith,M.E.B., Costelloe,S.J., Ward,J.M., Hailes,H.C., Dalby,P.A. (2008). Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde. Journal of Biotechnology 134, 240-245.

Smith,M.E.B., Hibbert,E.G., Jones,A.B., Dalby,P.A, Hailes,H.C. (2008). Enhancing and reversing the enantioselectivity of E. coli transketolase via single point mutations. Advanced Synthesis and catalysis 350, 2631-2638

Irvine A., Meng Q.H., Afzal F., Ho J., Wong J.B., Hailes H.C., Tabor A.B., McEwan J.R., Hart S. L (2008). Receptor Targeted Nanocomplexes Optimized for Gene Transfer to Primary Vascular Cells and Explant Cultures of Rabbit Aorta. Molecular Therapy, 2008, 16, 508-515.

Pilkington-Miksa M.A., Sarkar S., Writer M.J., Barker S.E., Ayazi Shamlou P., Hart S.L., Hailes H.C. and Tabor A.B. (2008). Synthesis of Bifunctional Integrin-Binding Peptides Containing PEG Spacers of Defined Length for Non-Viral Gene Delivery. Eur. J. Org. Chem., 2008, 2900-2914.

Tagalakis A.D., McAnulty R.J., Devaney J., Bottoms S.E., Wong J.B., Elbs M., Writer M.J., Hailes H.C., Tabor A.B., O'Callaghan C., Jaffe A. and Hart S.L. (2008). A receptor-targeted nanocomplex vector system optimized for respiratory gene transfer. Molecular Therapy, 2008, 16, 907-915.

Wong J.B., Grosse S., Tabor A.B., Hart S.L., and Hailes H.C. (2008) Acid Cleavable PEG lipids for Applications in a Ternary Gene Delivery Vector. Mol. BioSyst., 2008, 4, 532-541.

Hurley C.A., Wong J.B., Ho J., Writer M., Irvine S.A., Lawrence M.J. , Hart S.L., Tabor A.B. and Hailes H.C. (2008) Di- and Monocationic short PEG and Methylene Dioxyalkylglycerols for use in Synthetic Gene Delivery Systems. Org. Biomol. Chem., 2008, 6, 2554-2559.

Vareiro M. M. L. M. , Tranchant I., Maplin S., Zak K., Gani M.M., Selvin C.J., Hailes H.C., Tabor A.B., Cameron P.J., Jenkins A. T. A. , Williams D. E. (2008) Surface plasmon resonance-enhanced fluorescence implementation of a single-step competition assay: Demonstration of fatty acid measurement using an anti-fatty acid monoclonal antibody and a Cy5-labeled fatty acid. Analytical Chem. 377, 243-250

Hailes H.C. and Gunn R.G. (2008) Insights into the PI3K-PKB-mTOR Signalling Pathway from Small Molecule Probes. J. Chem. Biology, 2008, 1, 49-62.

Professor Elizabeth Hounsell [top]


N/A

Dr Stefan Howorka [top]

Artelsmair,H., Kienberger,F., Tinazli,A., Schlapak,R., Preiner,J., Wruss,J., Kastner,M., Saucedo-Zeni,N., Hoelzl,M.,C., Rankl,C., Baumgartner,W., Howorka,S., Blaas,D., Gruber,H.J., Tampé,R., Hinterdorfer,P. (2008). Atomic force microscopy-based nano-chip for the detection of human pathogenic viruses. Small 4(6), 847-854.

Howorka,S., Siwy,Z. (2008). Nanopores: Generation, engineering and single-molecule applications. in Handbook of Single-Molecule Biophysics. New York: Springer, in press Kinns,H., Howorka,S. (2008). The surface location of individual residues in a bacterial S-layer protein. Journal of Molecular Biology 377(2), 589-604.

Latini,G., Wykes,M., Schlapak,R., Howorka,S., Cacialli,F. (2008). Self-assembled monolayers of protonated poly(amidoamine) dendrimers on indium tin oxide. Applied Physics Letters 92(1), 013511.

Nick,M., Howorka,S. (2008). Chemical tags facilitate the detection of individual DNA strands with nanopores. Angewandte Chemie International Edition 47(30), 5565-5568.

Professor David Jones [top]


Edwards, Y.J., Bryson, K. & Jones, D.T. (2008) A meta-analysis of microarray gene expression in mouse stem cells: redefining stemness. PLoS ONE. 3, e2712.

Lobley, A.E., Nugent, T., Orengo, C.A. & Jones, D.T. (2008) FFPred: an integrated feature-based function prediction server for vertebrate proteomes. Nucleic Acids Res. May 7.

Siepen, J.A., Belhajjame, K., Selley, J.N., Embury, S.M., Paton, N.W., Goble, C.A., Oliver, S.G., Stevens, R., Zamboulis, L., Martin, N., Poulovassillis, A., Jones, P., Cote, R., Hermjakob, H., Pentony, M.M., Jones, D.T., Orengo, C.A., Hubbard, S.J. (2008) ISPIDER Central: an integrated database web-server for proteomics. Nucleic Acids Res. 2008 Apr 25.

Nugent, T., Mole, S. & Jones, D.T. (2008) The transmembrane topology of Batten disease protein CLN3 determined by consensus computational prediction constrained by experimental data. FEBS Lett. 582, 1019-1024.

Tan, C. & Jones, D.T. (2008) Using neural networks and evolutionary information in decoy discrimination for protein tertiary structure prediction. BMC Bioinformatics. 9, 94.


Dr Cristopher Kay [top]


Frank,R.A.W., Kay,C.W.M., Hirst,J., Luisi,B.F. (2008). Off-pathway, oxygen-dependent thiamine radical in the Krebs cycle. Journal of the American Chemical Society 130(5), 1662-1668.

Dr Nick Keep [top]

Patel, P. Harris, R., Geddes, S.M., Strehle1, E.-M., Watson, J.D., Bashir, R., Bushby, K., Driscoll, P.C. and Keep, N.H. (2008). Solution Structure of the Inner DysF Domain of Myoferlin and Implications for Limb Girdle Muscular Dystrophy Type 2B J. Mol. Biol. 379, 981-990.

Garg, R. Riento, K. Keep, N.H., Morris, J.D.H. and Ridley A.J. (2008). N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization. Biochemical Journal 411, 407-414

Dr Philip Lowden [top]

N/A

Dr Derek MacMillan [top]

Richardson, J.P.; Macmillan, D. Optimisation of chemical protein cleavage for erythropoietin semi-synthesis using native chemical ligation. Org. Biomol. Chem. 2008, 6, 3977 - 3982.

Marchesan, S.; Macmillan D. Chemoenzymatic Synthesis of GDP-Azidodeoxymannoses: Probes for Mannosyltransferase Activity. Chem. Commun. 2008, 4321 – 4323.

Li, J.; Taylor, I.A.; Lloyd, J.; Clapperton, J.A. Howell, S.; Macmillan, D.; Smerdon, S.J. Chk2 Oligomerisation Studied by Phosphopeptide Ligation: Implications for Regulation and Phosphodependant Interactions. J. Biol. Chem. 2008, 283 (51) 36019-36030.

McCullough, B.; Kalapothakis, J.; Eastwood, H.; Kemper, P.; Macmillan, D.; Dorin, J.; Taylor, K.; Barran, P., Development of an Ion Mobility Quadrupole Time of Flight Mass Spectrometer  - The MoQTOF, Anal. Chem. 2008, 80(16), 6336-6344.

Kärkkäinen, T.S.; Kartha, K. P. R.; MacMillan D.; Field, R.A. Iodine-mediated glycosylation en route to mucin-related glyco-aminoacids and glycopeptides, Carbohydrate Res., 2008, 343, 1830-1834.

Macmillan, D.; Richardson, J.P. Mucin-Based Vaccines, Fraser-Reid Ed. Glycoscience 2008, 2645-2698.

Taylor, K.; Clarke, D. J.; McCullough, B.; Chin, W.; Seo, E.; Yang, D.; Oppenheim, J.; Uhrin, D.; Govan, J. R. W.; Campopiano, D. J.; MacMillan, D.; Barran, P.; Dorin, J. R., Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of β-Defensin 3. J. Biol. Chem. 2008, 283, (11), 6631-6639.

Macmillan, D. Method of covalently linking a carbohydrate or polyalkylene oxide to a peptide, precursors for use in the method and resultant products. PCT Int. Appl. 2008, 102pp. CODEN:PIXXD2; WO2008001109.

Professor Charles Marson [top]

Assem el-SK, Peh KH, Wan BY, Middleton BJ, Dines J, Marson CM.(2008) Effects of a selection of histone deacetylase inhibitors on mast cell activation and airway and colonic smooth muscle contraction. Int Immunopharmacol. 2008 Dec 20;8(13-14):1793-801.

Dr Andrew Martin [top]


Abhinandan,K.R., Martin,A.C.R. (2008). Analysis and improvements to Kabat and structurally correct numbering of antibody variable domains. Molecular Immunology 45, 3832-3839.

Churamani,D., Boulware,M.J., Ramakrishnan,L., Geach,T.J., Martin,A.C.R., Vacquier,V.D., Marchant,J.S., Dale,L., Patel,S. (2008). Molecular characterisation of a novel cell surface ADP-ribosyl cyclase from the sea urchin. Cellular Signalling 12, 2347-2355.

McMillan LE, Martin AC.(2008) Automatically extracting functionally equivalent proteins from SwissProt. BMC Bioinformatics. 2008 Oct 6;9:418.

Dr Nigel Martin [top]


Hirsch,M., Tucker,A., Swift,S., Martin,N., Orengo,C., Kellam,P. and Liu,X. (2008). Improved robustness in time series analysis of gene expression data by polynomial model based clustering. Proceedings Lecture Notes in Computer Science , 4216, 1-10

Siepen,J.A., Belhajjame,K., Selley,J.N., Embury,S.M., Paton,N.W., Goble,C.A., Oliver,S.G., Stevens,R., Zamboulis,L., Martin,N., Poulovassillis,A., Jones,P., Cote,R., Hermjakob,H., Pentony,M.M., Jones,D.T., Orengo,C.A., Hubbard,S.J. (2008). ISPIDER Central: an integrated database web-server for proteomics. Nucleic Acids Research 36, W485-W490.

Yeats,C., Lees,J., Reid,A., Kellam,P., Martin,N., Liu,X., Orengo,C. (2008). Gene3D: comprehensive structural and functional annotation of genomes. Nucleic Acids Research 36, D414-D418.

Dr Neil McDonald [top]

Mouilleron S, Guettler S, Langer CA, Treisman R & McDonald NQ. (2008) Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL. EMBO J. 27 (23): 1-11

Ciccia A, McDonald N & West SC. (2008) Structural and functional relationships of the XPF/Mus81 family of proteins. Annu Rev Biochem. 77: 259-287

Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane EK, McDonald NQ. (2008) Structure of a conserved dimerisation domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. J. Biol. Chem. 8; 823(32) 22325-35.


Dr Adam MacKay [top]


N/A

Professor Boris Mirkin [top]

N/A

Dr Carolyn Moores [top]

Moores C.A. (In press) Studying microtubules by electron microscopy in “Introduction to Electron Microscopy for Biologists” (ed. T.D. Allen). Academic Press, Elsevier, Inc. Moores CA, Milligan, RA (2008) Visualisation of a kinesin-13 motor on microtubule end mimics. J. Mol Biol. 377(3):647-54.

Ciferri C, Pasqualato S, Screpanti E, Varetti G, Santaguida S, Dos Reis G, Maiolica A, Polka J, De Luca JG, De Wulf P, Salek M, Rappsilber J, Moores CA, Salmon ED, Musacchio A. (2008) Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Cell. 133(3):427-39.


Professor David Moss [top]

Todman SJ, Halling-Brown MD, Davies MN, Flower DR, Kayikci M, Moss DS. (2008) Toward the atomistic simulation of T cell epitopes automated construction of MHC: peptide structures for free energy calculations. J Mol Graph Model. 26(6):957-61.

Halling-Brown M, Sansom CE, Davies M, Titball RW, Moss DS. (2008) Are bacterial vaccine antigens T-cell epitope depleted? Trends Immunol. 29(8):374-9.

Halling-Brown MD, Moss DS, Shepherd AJ. (2008) Towards a lightweight generic computational grid framework for biological research. BMC Bioinformatics. 9:407.

Dr Sylvia Nagl [top]

N/A

Dr Irilenia Nobeli [top]

Favia, A.$, Nobeli, I.$, Glaser, F., and Thornton, J.M. (2008). Molecular docking for substrate identification: the short-chain dehydrogenases/reductases. J. Mol. Biol., 375, 855-874. $ Favia and Nobeli are joint first authors.

Bashton, M., Nobeli, I., and Thornton, J.M. (2008). PROCOGNATE: A cognate ligand domain mapping for enzymes. Nucleic Acids Res., 36, D618-D622.

Professor Christine Orengo [top]


Dessailly,B.H., Lensink,M.F., Orengo,C.A., Wodak,S.J. (2008). LigASite--a database of biologically relevant binding sites in proteins with known apo-structures. Nucleic Acids Research 36, D667-D673.

Hirsch,M., Tucker,A., Swift,S., Martin,N., Orengo,C., Kellam,P. and Liu,X. (2008). Improved robustness in time series analysis of gene expression data by polynomial model based clustering. Proceedings Lecture Notes in Computer Science, , 4216, 1-10

Lobley,A., Nugent,T., Orengo,C. A., Jones,D.T. (2008). FFPred: an integrated feature-based function prediction server for vertebrate proteomes. Nucleic Acids Research 36(11), 1-6.

Marsden,R.L., Orengo,C.A. (2008). Target selection for structural genomics: an overview. in Kobe,B., Gus,M., Huber,T. (ed.) Structural Proteomics: High-Throughput Methods. Methods in Molecular Biology series. Humana Press, 426:3-25.

Redfern,O.C., Dessailly,B., Orengo,C.A. (2008). Exploring the structure and function paradigm. Current Opinion in Structural Biology 18(3), 394-402.

Siepen,J.A., Belhajjame,K., Selley,J.N., Embury,S.M., Paton,N.W., Goble,C.A., Oliver,S.G., Stevens,R., Zamboulis,L., Martin,N., Poulovassillis,A., Jones,P., Cote,R., Hermjakob,H., Pentony,M.M., Jones,D.T., Orengo,C.A., Hubbard,S.J. (2008). ISPIDER Central: an integrated database web-server for proteomics. Nucleic Acids Research 36, W485-W490.

Yeats,C., Lees,J., Reid,A., Kellam,P., Martin,N., Liu,X., Orengo,C. (2008). Gene3D: comprehensive structural and functional annotation of genomes. Nucleic Acids Research 36, D414-D418.

Addou, S., Rentzsch, R., Lee, D. & Orengo, C.A. Domain-Based and Family-Specific Sequence Identity Thresholds Increase the Levels of Reliable Protein Function Transfer. J Mol Biol 387(2), 416-430(2008). Carter, P., Lee, D. & Orengo, C. Target Selection in Structural Genomics Projects to Increase Knowledge of Protein Structure and Function Space. Structural Genomics, (Elsevier, 2008). Cuff, A.L et al. Classification of protein structures, in Computational Structural Biology: Methods and Applications (World Scientific, 2008)

Marsden, R.L. & Orengo, C.A. The classification of protein domains. Methods Mol Biol 453, 123-46 (2008).

Redfern, O. et al. Automated Systems for Genome Annotation. Genome Biol (2008).

Reid, A., Yeats, C., Lees, J. & Orengo, C. Structural Annotation of Genomes. In Structural Bioinformatics (eds. Gu, J. & Bourne, P.E.) (Wiley, 2008).

Yeats, C. et al. Gene3D: comprehensive structural and functional annotation of genomes. Nucleic Acids Res 36, D414-8 (2008). Yeats, C., Linial, M., Veuthey, A.L. & Orengo, C. Annotating protein functions from sequences. in Modern genome annotation: the Biosapiens Network. (ed. Frishman, D.) (Wiley, 2008).


Dr Elena Orlova [top]

Elad N, Clare DK, Saibil HR, Orlova EV. (2008) Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections. J Struct Biol.162(1):108-20.

Salih O, Remaut H, Waksman G, Orlova EV. (2008) Structural analysis of the Saf pilus by electron microscopy and image processing. J Mol Biol. 379(1):174-87.

Professor Steve Perkins [top]


Bonner,A., Furtado,P.B., Almogren,A., Kerr,M. A., Perkins,S.J. (2008). Implications of the near-planar solution structure of human myeloma dimeric IgA1 for mucosal immunity and IgA nephropathy. The Journal of Immunology 180, 1008-1018.

Edey,M. M., Mead,P.A., Saunders,R.E., Perkins,S. J., Goodship,T.H.J., Kanagasundaram,N.S. (2008). Association of Factor H mutation with hemolytic uremic syndrome following a diarrheal illness. American Journal of Kidney Diseases 51, 487-490.

Furtado,P.B., Huang,C.Y., Ihyembe,D., Hammond,R. A., Marsh,H.C., Perkins,S.J. (2008). The partly-folded back solution structure arrangement of the 30 SCR domains in human complement receptor type 1 (CR1) permits access to its C3b and C4b ligands. Journal of Molecular Biology 375, 102-118.

Li,K., Okemefuna,A.I., Gor,J., Hannan,J.P., Asokan,R., Holers,V.M., Perkins,S.J. (2008). Solution structure of the complex formed between human complement C3d and full-length complement receptor type 2. Journal of Molecular Biology 384(1), 137-150.

Nan,R., Gor,J., Lengyel,I., Perkins,S.J. (2008). Uncontrolled Zinc- and Copper-Induced Oligomerisation of the Human Complement Regulator Factor H and Its Possible Implications for Function and Disease. Journal of Molecular Biology 384(5), 1341-1352.

Nan,R., Gor,J., Perkins,S.J. (2008). Implications of the progressive self-association of wild-type human Factor H for complement regulation and disease. Journal of Molecular Biology 375, 891-900.

Okemefuna,A. I., Gilbert,H. E., Griggs,K. M., Ormsby,R. J., Gordon,D. L. & Perkins,S. J. (2008). The regulatory SCR-1/5 and cell-surface-binding SCR-16/20 fragments of Factor H reveal partially folded-back solution structures and different self-associative properties. Journal of Molecular Biology 375, 80-101.

Perkins,S. J. & Bonner,A. (2008). Structure determinations of human and chimaeric antibodies by solution scattering and constrained molecular modelling. Biochemical Society Transactions 36, 37-42.

Perkins,S. J., Okemefuna,A. I., Fernando,A. N., Bonner,A., Gilbert,H. E. & Furtado,P. B. (2008). X-ray and neutron scattering data and their constrained molecular modelling. Methods Cell Biology 84, 375-423

Saunders,R.E., Perkins,S.J. (2008). CoagMDB: A database analysis of missense mutations within four conserved domains in five Vitamin K-dependent coagulation serine proteases using a text-mining tool. Human Mutation 29, 333-344.

Dr Saul Purton [top]

Loiselay,C., Gumpel,N.J., Girard-Bascou,J., Watson,A.T., Purton,S., Wollman,F.-A., Choquet,Y. (2008). Molecular identification and function of cis- and trans-acting determinants for petA transcript stability in Chlamydomonas chloroplasts. Molecular and Cellular Biology 28(17), 5529-5542.

Professor Peter Rich [top]

Maréchal,A., Ingledew,W.J., Rich,P.R. (2008). Time-resolved FTIR study of CO recombination with horseradish peroxidase. Biochemical Society Transactions 36, 1165-1168.

Rich,P.R. (2008). A perspective on Peter Mitchell and the chemiosmotic theory. Journal of Bioenergetics and Biomembranes 40, 407-410.

Rich,P.R., Maréchal,A. (2008). Rich, P.R. and Maréchal, A. (2008) Carboxyl group functions in the heme-copper oxidases: Information from mid-IR vibrational spectroscopy, Biochim. Biophys. Acta, 1777, 912-918. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1777(7-8), 912-918.

Professor David Saggerson [top]

N/A

Professor Helen Saibil [top]

Saibil HR. (2008) Chaperone machines in action. Curr Opin Struct Biol. 18(1):35-42. Epub 2008 Feb 1. Review.

Lukoyanova N, Saibil HR. (2008) Friend or foe: the same fold for attack and defense. Trends Immunol. 29(2):51-3. Epub 2008 Jan 8. Review.

Clare DK, Stagg S, Quispe J, Farr GW, Horwich AL, Saibil HR. (2008) Multiple states of a nucleotide-bound group 2 chaperonin. Structure.16(4):528-34.

Krojer T, Sawa J, Schäfer E, Saibil HR, Ehrmann M, Clausen T. (2008) Structural basis for the regulated protease and chaperone function of DegP. Nature. 453(7197):885-90.

Elad N, Clare DK, Saibil HR, Orlova EV. (2008) Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections. J Struct Biol.162(1):108-20.

Dr Joanne Santini [top]


Schoepp-Cothenet,B., Duval,S., Santini,J,M., Nitschke,W. (2008). Comment on "Arsenic (III) fuels anoxygenic photosynthesis in hot spring biofilms from Mono Lake, California". Science 321(5914), 583-583.

Dr Renos Savva [top]


N/A

Dr David Selwood [top]

Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ, Hobbs AJ. (2008) Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension. Am J Respir Crit Care Med. 178(8):861-9.

Professor Elizabeth Shephard [top]

Phillips,I.R., Shephard,E.A. (2008). Flavin-Containing Monoooxygenases (FMOs): Polymorphisms in Disease and Drug Response. Trends in Pharmacological Sciences 29, 294-301.

Veeramah,K.R., Thomas,M.G., Weale,M.E., Zeitlyn,D., Tarekegn,A., Bekele,E., Mendell,N.R., Shephard,E.A., Bradman,N., Phillips,I.R. (2008). The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa. Pharmacogenetics and Genomics 18, 877-886.

Dr Adrian Shepherd
[top]

Halling-Brown M, Shepherd AJ. (2008) Constructing computational pipelines. Methods Mol Biol. 2008;453:451-70. Clegg AB, Shepherd AJ. (2008) Text mining. Methods Mol Biol. 2008;453:471-91.

Halling-Brown MD, Moss DS, Shepherd AJ. (2008) Towards a lightweight generic computational grid framework for biological research. BMC Bioinformatics. 9:407.

Pappalardo F, Halling-Brown MD, Rapin N, Zhang P, Alemani D, Emerson A, Paci P, Duroux P, Pennisi M, Palladini A, Miotto O, Churchill D, Rossi E, Shepherd AJ, Moss DS, Castiglione F, Bernaschi M, Lefranc MP, Brunak S, Motta S, Lollini PL, Basford KE, Brusic V. (2009) ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization. Brief Bioinform. 10(3):330-40.

Dr Christine Slingsby [top]

Evans, P., Slingsby, C. and Wallace, B.A. (2008) Association of Partially-Folded Lens betaB2-Crystallins with the alpha-Crystallin Molecular Chaperone. Biochemical J. 409: 691-699.

Dr Alona Sosinsky [top]

N/A

Prof Kaila Srai [top]


Abbott,G.,W., Ramesh,B., Srai,S.K. (2008). Secondary structure of the MiRP1 (KCNE2) potassium channel ancillary subunit. Protein and Peptide Letters 15(1), 63-75

Anty,R., Dahman,M., Iannelli,A., Gual,P., Staccini-Myx,A., Amor,I.B., Luciani,N., Saint-Paul,M.C., Huet,P.M., Sadoul,J.L., Srai S.K., Unwin,R., Gugenheim,J., Le Marchand-Brustel,Y., Tran,A., Bekri,S. (2008). Bariatric surgery can correct iron depletion in morbidly obese women: a link with chronic inflammation. Obesity Surgery 18(6), 709-714

Chaston,T., Chung,B., Mascarenhas,M., Marks,J., Patel,B.0., Srai,S.K., Sharp,P. (2008). Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells. Gut 57(3), 374-382.

Heaton SJ, Eady JJ, Parker ML, Gotts KL, Dainty JR, Fairweather-Tait SJ, McArdle HJ, Srai KS, Elliott RM. (2008) The use of BeWo cells as an in vitro model for placental iron transport. Am J Physiol Cell Physiol. 295(5):C1445-53.

Dr Alethea Tabor [top]


Irvine A., Meng Q.H., Afzal F., Ho J., Wong J.B., Hailes H.C., Tabor A.B., McEwan J.R., Hart S. L (2008). Receptor Targeted Nanocomplexes Optimized for Gene Transfer to Primary Vascular Cells and Explant Cultures of Rabbit Aorta. Molecular Therapy, 2008, 16, 508-515.

Pilkington-Miksa M.A., Sarkar S., Writer M.J., Barker S.E., Ayazi Shamlou P., Hart S.L., Hailes H.C. and Tabor A.B. (2008). Synthesis of Bifunctional Integrin-Binding Peptides Containing PEG Spacers of Defined Length for Non-Viral Gene Delivery. Eur. J. Org. Chem., 2008, 2900-2914.

Tagalakis A.D., McAnulty R.J., Devaney J., Bottoms S.E., Wong J.B., Elbs M., Writer M.J., Hailes H.C., Tabor A.B., O'Callaghan C., Jaffe A. and Hart S.L. (2008). A receptor-targeted nanocomplex vector system optimized for respiratory gene transfer. Molecular Therapy, 2008, 16, 907-915.

Wong J.B., Grosse S., Tabor A.B., Hart S.L., and Hailes H.C. (2008) Acid Cleavable PEG lipids for Applications in a Ternary Gene Delivery Vector. Mol. BioSyst., 2008, 4, 532-541.

Hurley C.A., Wong J.B., Ho J., Writer M., Irvine S.A., Lawrence M.J. , Hart S.L., Tabor A.B. and Hailes H.C. (2008) Di- and Monocationic short PEG and Methylene Dioxyalkylglycerols for use in Synthetic Gene Delivery Systems. Org. Biomol. Chem., 2008, 6, 2554-2559.

Vareiro M. M. L. M. , Tranchant I., Maplin S., Zak K., Gani M.M., Selvin C.J., Hailes H.C., Tabor A.B., Cameron P.J., Jenkins A. T. A. , Williams D. E. (2008) Surface plasmon resonance-enhanced fluorescence implementation of a single-step competition assay: Demonstration of fatty acid measurement using an anti-fatty acid monoclonal antibody and a Cy5-labeled fatty acid. Analytical Chem., 2008, 377, 243-250

Dr Geraint Thomas [top]


Webb RJ, Tinworth L, Thomas GM, Zaccolo M, Carroll J. (2008) Developmentally acquired PKA localisation in mouse oocytes and embryos. Dev Biol. 317(1):36-45.

Dr Salvador Tomas [top]


Milanesi L, Tomas S, Hunter CA, Weinstein JA, Edge R, Navaratnam S, Waltho JP, Best J.(2008) A pulse--radiolysis approach to fast reductive cleavage of a disulfide bond to uncage enzyme activity. Free Radic Biol Med. 45(9):1271-8.

Dr Maya Topf [top]


Connell SR*, Topf M*, et al. (2008). A new tRNA-intermediate revealed on the ribosome during EF4-mediated back-translocation. Nat Struct Mol Biol, 15, 910 - 915.

Topf M, et al. (2008). Protein structure fitting and refinement guided by CryoEM density. Structure 16, 295-307.

Chandramouli P, Topf M, et al. (2008). Structure of the mammalian 80S ribosome at 8.7 Å resolution. Structure 16, 535-548.

Cong Y, Topf M, Sali A, Matsudaira P, Dougherty M, Chiu W, Schmid MF.(2008) Crystallographic conformers of actin in a biologically active bundle of filaments. J Mol Biol. 375(2):331-6.

Alber F, Förster F, Korkin D, Topf M, Sali A.(2008) Integrating diverse data for structure determination of macromolecular assemblies. Annu Rev Biochem. 2008;77:443-77. Review.

Booth CR, Meyer AS, Cong Y, Topf M, Sali A, Ludtke SJ, Chiu W, Frydman J. (2008).Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT. Nat Struct Mol Biol. 15(7):746-53.

Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W. (2008) Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc Natl Acad Sci U S A. 105(28):9610-5.

Harvey RJ, Topf M, Harvey K, Rees MI.(2008) The genetics of hyperekplexia: more than startle! Trends Genet. 24(9):439-47. Epub 2008 Aug 15. Review.

Miller PS, Topf M, Smart TG. (2008) Mapping a molecular link between allosteric inhibition and activation of the glycine receptor. Nat Struct Mol Biol. 15(10):1084-93.


Dr Andrea Townsend-Nicholson [top]


King,B.F., Townsend-Nicholson,A. (2008). α,β-methyleneATP: a P2Y11 agonist and smooth muscle relaxant. Purinergic Signalling 4, S131.

King,B.F., Townsend-Nicholson,A. (2008). Benzoyl-benzoyl-ATP: a smooth muscle relaxant and P2Y11 agonist. Purinergic Signalling 4, S132.

King,B.F., Townsend-Nicholson,A. (2008). Involvement of P2Y1 and P2Y11 purinoceptors in parasympathetic inhibition of colonic smooth muscle. The Journal of Pharmacology and Experimental Therapeutics 324(3), 1055-1063.

Townsend-Nicholson,A., Drew,C.M., Saunders-Wage,E., King,B.F. (2008). Modulation of P2Y11 by compounds with activity at guinea-pig taenia coli. Purinergic Signalling 4, S88-S89.


Dr Irina Tsaneva [top]


Baharoglu,Z., Bradley,A.S., Le Masson,M., Tsaneva,I., Michel,B. (2008). ruvA Mutants that resolve Holliday junctions but do not reverse replication forks. PLoS Genetics 4(3), e1000012.

Gospodinov,A., Tsaneva,I., Anachkova,B. (2008). RAD51 foci formation in response to DNA damage is modulated by TIP49. The International Journal of Biochemistry and Cell Biology


Dr Cara Vaughan [top]


Hawkins TA, Haramis AP, Etard C, Prodromou C, Vaughan CK, Ashworth R, Ray S, Behra M, Holder N, Talbot WS, Pearl LH, Strähle U, Wilson SW. (2008) The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development. 135(6):1147-56.

Fulton DC, Stettler M, Mettler T, Vaughan CK, Li J, Francisco P, Gil M, Reinhold H, Eicke S, Messerli G, Dorken G, Halliday K, Smith AM, Smith SM, Zeeman SC.(2008) Beta-AMYLASE4, a noncatalytic protein required for starch breakdown, acts upstream of three active beta-amylases in Arabidopsis chloroplasts. Plant Cell. 20(4):1040-58.

Millson SH, Vaughan CK, Zhai C, Ali MM, Panaretou B, Piper PW, Pearl LH, Prodromou C.(2008).Chaperone ligand-discrimination by the TPR-domain protein Tah1. Biochem J. 413(2):261-8.

Vaughan CK, Mollapour M, Smith JR, Truman A, Hu B, Good VM, Panaretou B, Neckers L, Clarke PA, Workman P, Piper PW, Prodromou C, Pearl LH.(2008) Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Mol Cell. 231(6):886-95.


Professor Gabriel Waksman [top]


S.J. Jakubowski, J. Kerr, I. Garza, V. Krishnamoorthy, R. Bayliss, G. Waksman, and P.J. Christie* (2008). Agrobacterium VirB10 domain requirements for type IV secretion and T pilus biogenesis. Mol. Micro. 71:779-794.

G. Meng, J. StGemes and G. Waksman* (2008). Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter. Journal of Molecular Biology. 384:824-836.

R. Fronzes, H. Remaut, and G. Waksman* (2008). Architectures and biogenesis of non-flagellar protein appendages in Gram-negative bacteria. New EMBO member review. EMBO Journal. 27:2271-2280.

D. Verger, R. Rose, E. Paci, G. Costakes, T. Daviter, S. Hultgren, H. Remaut, A. Ashcroft, S. Radford*, and G. Waksman* (2008). Structural and functional insights into the adaptor subunit function of PapF in pilus biogenesis. Structure. 16:1724-1731.

R. Rose, D. Verger, T. Daviter, H. Remaut, G. Waksman*, A Ashcroft*, and S. Radford* (2008). Unravelling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry. Proc. Natl. Acad. Sci. USA. 105:12873-12878.

R.J. Rose, T.S. Welsh, G. Waksman, A.E. Ashcroft, S.E. Radford, and Emanuele Paci* (2008). Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics. J. Mol. Biol. 375(4):908-19.

R.J. S. Backert*, R. Fronzes, and G. Waksman (2008). VirB2/VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems? Trends in Microbiology. 16:409-413.

W.J. Allen, P.J. Rothwell, and G. Waksman* (2008). An intramolecular FRET system monitors fingers subdomain opening in Klentaq1. Protein Science. 17:401-408.

G. De Fabritiis*, S. Geroult, P.V. Coveney* and G. Waksman* (2008). Insights from the energetics of water binding at the domain-ligand interface of the Src SH2 domain. PROTEINS: Structure, Function, and Bioinformatics. 72(4):1290-7

C. Bagneris, A. Ageichik, N. Cronin, B. Wallace, M. Collins, C. Boshoff, G. Waksman*, T. Barrett* (2008). Crystal structure of a vFlip-IKKg complex: Insights into viral activation of the IKK signalosome. Molecular Cell. 30:620-631.

H. Remaut, C. Tang, N.S. Henderson, J.S. Pinkner, T. Wang, S.J. Hultgren*, D.G. Thanassi*, G. Waksman*, H. Li* (2008). Fiber Formation Across the Bacterial Outer Membrane by the Chaperone/Usher Pathway. Cell. 133:640-652.

O. Salih, H. Remaut, G. Waksman and E. Orlova*. Structural Analysis of the Saf Pilus by Electron Microscopy and Image Processing. Journal of Molecular Biology. 379:174-187.

Professor Bonnie Wallace [top]

Evans, P., Slingsby, C., and Wallace, B.A. (2008) Association of Partially-Folded Lens ßB2-Crystallins with the a-Crystallin Molecular Chaperone. Biochemical Journal 408:691-699.

Cowieson, N.P., Miles, A.J., Robin, G., Forwood, J.K., Kobe, B., Martin, J.L., and Wallace, B.A. (2008) Evaluating Protein: Protein Complex Formation using Synchrotron Radiation Circular Dichroism Spectroscopy. Proteins: Structure Function Bioinformatics 70:1142-1146.

Bulheller, B., Miles, A.J., Wallace, B.A., and Hirst, J. (2008) Charge-transfer transitions in the vacuum ultraviolet of protein circular dichroism spectra. J. Phys. Chem. B 112:1866-1874.

Whitmore, L., and Wallace, B.A. (2008) Protein Secondary Structure Analyses from Circular Dichroism Spectroscopy: Methods and Reference Databases. Biopolymers 89:392-400.

Miles, A.J., Drechsler, A., Kristan, K., Anderluh, G., Norton, R.S., Wallace, B.A. and Separovic, F. (2008) The effects of lipids on the structure of the eukaryotic cytolysin equinatoxin II: a synchrotron radiation circular dichroism spectroscopic study. BBA (Biomembranes) 1778: 2091-2096.

Lampert, A., O'Reilly, A.O., Dib-Hajj, S.D., Tyrrell, L., Wallace, B.A., and Waxman, S.G. (2008) A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation. J. Biol. Chem. 283:24118-24127.

Nurani, G., Radford, M., Charalambous, K., O'Reilly, A.O., Cronin, N., Haque, S., and Wallace, B.A. (2008) Tetrameric Bacterial Sodium Channels: Characterisation of Structure, Stability, and Drug Binding. Biochemistry 47:8114-8121.

O'Reilly, A.O., Charalambous, K., Nurani, G., Powl, A.M. and Wallace, B.A. (2008) G219S Mutagenesis as a Means of Stabilising Conformational Flexibility in the Bacterial Sodium Channel NaChBac. Molecular Membrane Biology 25: 670-676.


Prof John Ward [top]


Costelloe,S.J., Ward,J.M., Dalby,P.A. (2008). Evolution of the TPP-dependent enzyme family. Journal of Molecular Evolution 66, 36-49.

Hibbert,E.G., Senussi,T., Smith,M.E.B., Costelloe,S.J., Ward,J.M., Hailes,H.C., Dalby,P.A. (2008). Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde. Journal of Biotechnology 134, 240-245.

Hilker,I., Gutiérrez,M.C., Furstos,R., Ward,J., Wohlgemuth. R., Alphand V. (2008). Preparative scale Baeyer-Villiger biooxidation at high concentration using recombinant Escherichia coli and in situ substrate feeding and product removal process. Nature Protocols 3, 546-554.

Kong,S., Rock,C.F., Booth,A., Willoughby,N.,O'Kennedy,R.D., Relton,J., Ward,J.M., Hoare,M., Levy,M.S. (2008). Large-scale plasmid DNA processing: evidence that cell harvesting and storage methods affect yield of supercoiled plasmid DNA. Biotechnology and Applied Biochemistry.

Mullen,L.M., Nair,S.P., Ward,J.M., Rycroft,A.N., Williams,R.J., Robertson,G., Mordan,N.J., Henderson,B. (2008). Novel adhesin from Pasteurella multiocida that binds to the integrin-binding fibronectin FNIII 9-10 repeats. Infection and Immunity 76(3), 1093-1104.

Mullen,L.M., Bossé,J.T., Nair,S.P., Ward,J.M., Rycroft,A.N., Robertson,G., Langford,P.R., Henderson,B. (2008). Pasteurellaceae comE1 proteins combine the properties of fibronectin adhesins and DNA binding competence proteins. PLoS One 3(12), 1-11.

Yau,S.Y., Keshavarz-Moore,E., Ward,J. (2008). Host strain influences onsupercoiled plasmid DNA production in E.coli; implications for efficient design of large scale processes. Biotechnology and Bioengineering 101(3), 529-544.

Dr Finn Werner [top]


Werner,F. (2008). Structural evolution of multisubunit RNA polymerases. Trends in Microbiology 16(6), 247-250.

Dr Lorenz Wernisch [top]

N/A

Dr Jonathan Wilden [top]

Chudasama V, Wilden JD. (2008) A versatile synthesis of 2,4-substituted oxazoles. Chem Commun (Camb). 32):3768-70.

Dr Mark Williams [top]

Tjelvar S.G. Olsson, Mark A. Williams*, William R. Pitt and John E. Ladbury* (2008). The thermodynamics of protein-ligand interaction and solvation: Insights for ligand design. J. Mol. Biol. 384, 1002-1017.

Jonathan D. Taylor, Abdesamad Ababou, Radwan R. Fawaz, Christopher J. Hobbs, Mark A. Williams and John E. Ladbury (2008). Structure, dynamics and binding thermodynamics of v-Src SH2 domain: Implications for drug design. Proteins Struct. Funct. Bioinformatics. 73, 929-40.

Dr Steve Wood [top]

N/A

Dr Xuemei Yuan [top]

Yue,Z., Carvalho,A., Xu,Z., Yuan,X., Cardinale,S., Ribeiro,S., Lai,F., Ogawa,H., Gudmundsdottir,E., Gassmann,R., Morrison,C.G., Ruchaud,S., Earnshaw,W.C. (2008). Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line. The Journal of Cell Biology 183(2), 279-296.



 





 
 
   
     
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