Quang-De´ Nguyena, Graham Smith, Matthias Glaser, Meg Perumal, Erik Årstad and Eric O. Aboagye (2009). Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide. Proc Natl Acad Sci U S A. 106:16375-16380; [Epub aheadof print]
De Rosales RTM, Årstad E, Blower P (2009). Nuclear Imaging of Molecular Processes in Cancer. Target Oncol. Sep 25. [Epub ahead of print]
Leyton J, Graham S, Zhao Y, Perumal M, Nguyen QD, Robins E, Årstad E, Aboagye E (2009). [18F]Fluoromethyl-[1,2-2H4]-Choline. A novel Radiotracer for Imaging Choline Metabolism in Tumors by Positron Emission Tomography. Cancer Res. 69(19):7721-8. Epub 2009 Sep 22.
Glaser M, Årstad E, Luthra SK, Robins EG (2009). Two-step radiosynthesis of [18F]N-succinimidyl-4-fluorobenzoate ([18F]SFB). J. Label Compd. Radiopharm [Epub ahead of print]
Schoultz BW, Årstad E, Marton J, Willoch F, Drzezga A, Wester HJ, Henriksen G (2008). A New Method for Radiosynthesis of 11C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [11C]GR103545. The Open Medicinal Chemistry Journal, 2(3), 72-74.
J. R. Baker, L. M. Tedaldi, M. E. B. Smith, R. Nathani. (2009) Bromomaleimides; new reagents for the selective and reversible modification of cysteine. Chem. Comm. (43):6583-5. Epub 2009 Sep 16
Tedaldi LM, Baker JR. In situ reduction in photocycloadditions: a method to prevent secondary photoreactions. (2009) Org Lett. 11(4):811-4.
Gooptu B, Miranda E, Nobeli I, Mallya M, Purkiss A, Brown SC, Summers C, Phillips RL, Lomas DA, Barrett TE.(2009) Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design. J Mol Biol. 387(4):857-68.
Westwood I.M.†, Bhakta, S. †, Russell, A.J. †, Fullam, E., Anderton, M.C., Akane Kawamura, A., Mulvaney, A.W., Vickers, R.J., Bhowruth, V., Besra, G.S., Lalvani, A., Davies, S.G. and Sim, E. († equal first authors) (2009) Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars. Protein & Cell published ahead of print
Basavannacharya, C.; Robertson, G.; Munshi, T.; Keep, N. and Bhakta, S. (2009) ATP-dependent MurE ligase in Mycobacterium tuberculosis: Biochemical and structural characterisation. Tuberculosis (Elsevier) published online ahead of print.
Gupta, A.; Bhakta, S., Kundu, S., Gupta, M., Srivastava, B. S. and Srivastava, R. (2009) Drug resistant Mycobacterium aurum: A model for high throughput anti-Tuberculosis drug screening. J .Antimicrob Chemotherapy 64(4):774-81.
Agromayor,M., Carlton,J.G., Phelan,J.P., Matthews,D.R., Carlin,L.M., Ameer-Beg,S., Bowers,K., Martin-Serrano,J. (2009). Essential Role of hIST1 in Cytokinesis. Molecular Biology of the Cell 20(5), 1374-1387.
Bruce,E.A., Medcalf,L., Crump,C.M., Noton,S.L., Stuart,A.D., Wise,H.M., Elton,D., Bowers,K., Digard,P. (2009). Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-independent pathway. Virology 390(2), 268-278.
Luzio,J.P., Piper,S.C., Bowers,K., Parkinson,M.D., Lehner,P.J., Bright,N.A. (2009). ESCRT proteins and the regulation of endocytic delivery to lysosomes. Biochemical Society Transactions 37, 178-180.
Fitzmaurice,R.J., Ahern,J.M., Caddick,S. (2009). Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates. Organic & Biomolecular Chemistry, 7(2) 235-237
King,F.D., Aliev,A.E., Caddick,S., Tocher,D.A., Courtier-Murias,D. (2009). A facile synthesis of pyrrolo-(di)-benzazocinones via an intramolecular N-acyliminium ion cyclisation. Organic & Biomolecular Chemistry, 7 (1) 167-177 Caddick,S., Fitzmaurice,R. (2009). Microwave enhanced synthesis. Tetrahedron, 65 (17) 3325-3355
Cressina,E., Lloyd,A.J., De Pascale,G., Mok,B.J., Caddick,S., Roper,D.I., Dowson,C.G., Bugg,T.D.H. (2009). Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors. Bioorganic & Medicinal Chemistry, 17 (9), 3443-3455
Esposito,O., Roberts,D.E., Cloke,F.G.N., Caddick,S., Green,J.C., Hazari,N., Hitchcock,P.B. (2009). Carbon-Silicon Bond Activation by [Pd(ItBu)(2)] - the MolecularStructures of [Pd(Me3Si)(ItBu)(mu-I)](2) and [Pd(CH(2)ItBu)I-2]. European Journal of Inorganic Chemistry (13), 1844-1850
Aliev,A.E., Sinclair,A.J., Zhou,S., Wilden,J.D., Caddick,S., Kullmann,D.M., Rusakov,D.A. (2009). Density functional and spectroscopic studies of nitrogen inversion in substituted dizocilpines. Journal of Physical Organic Chemistry, 22 (6), 607-612
Nunes,J.P.M., Alfonso,C.A.M., Caddick,S. (2009). Asymmetric synthesis of functionalised cyclopentenones via organocatalysed rearrangement and enzymatic resolution of pyranones. Tetrahedron Letters, 50 (26), 3706-3708
King,F.D., Aliev,A.E., Caddick,S., Copley,R.C.B. (2009). An investigation into the electrophilic cyclisation of N-acyl-pyrrolidinium ions: a facile synthesis of pyrrolo-tetrahydroisoquinolones and pyrrolo-benzazepinones. Organic & Biomolecular Chemistry, 7 (17), 3561-3571
Lewis,A.K.D., Caddick,S., Esposito,O., Cloke,F.G.N., Hitchcock,P.B., (2009). Synthetic and structural studies on amine coordination to Pd-N-heterocyclic carbene complexes. Dalton Transactions, (35), 7094-7098
Lee,C.C., Fitzmaurice,R.J., Caddick,S. (2009). 3,5-Isoxazoles from alpha-bromo-pentafluorophenyl vinylsulfonates: Synthesis of sulfonates and sulphonamides. Organic & Biomolecular Chemistry, 7 (21), 4349-4351
Goumans,T.P.M., Catlow,C.R.A., Brown,W.A. (2009). Formation of H2 on an olivine surface: a computational study. Monthly Notices of the Royal Astronomical Society 393, 1403-1407.
Goumans,T.P.M., Catlow,C.R.A., Brown,W.A., Kastner,J., Sherwood,P. (2009). An embedded cluster study of the formation of water on interstellar dust grains. Physical Chemistry Chemical Physics 11, 5431-5436.
Hsu ST, Cabrita LD, Fucini P, Dobson CM, Christodoulou J. (2009) Structure, dynamics and folding of an immunoglobulin domain of the gelation factor (ABP-120) from Dictyostelium discoideum. J Mol Biol. 2009 May 15;388(4):865-79.
Hsu ST, Cabrita LD, Fucini P, Christodoulou J, Dobson CM. (2009) Probing side-chain dynamics of a ribosome-bound nascent chain using methyl NMR spectroscopy. J Am Chem Soc. 2009 Jun 24;131(24):8366-7.
Cabrita LD, Hsu ST, Launay H, Dobson CM, Christodoulou J. (2009) Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22239-44.
Roodveldt C, Bertoncini CW, Andersson A, van der Goot AT, Hsu ST, Fernández-Montesinos R, de Jong J, van Ham TJ, Nollen EA, Pozo D, Christodoulou J, Dobson CM. (2009) Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO J. 2009 Dec 2;28(23):3758-70.
Vuchelen A, O'Day E, De Genst E, Pardon E, Wyns L, Dumoulin M, Dobson CM, Christodoulou J, Hsu ST.(2009) ((1)H, (13)C and (15)N assignments of a camelid nanobody directed against human alpha-synuclein. Biomol NMR Assign. 2009 Dec;3(2):231-3.
Lendel C, Bertoncini CW, Cremades N, Waudby CA, Vendruscolo M, Dobson CM, Schenk D, Christodoulou J, Toth G. (2009) On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and Lacmoid. Biochemistry. 2009 Sep 8;48(35):8322-34.
Hsu ST, Cabrita LD, Christodoulou J, Dobson CM. (2009) 5.1H, 15N and 13C assignments of domain 5 of Dictyostelium discoideum gelation factor (ABP-120) in its native and 8M urea-denatured states. Biomol NMR Assign. 2009 Jun;3(1):29-31.
α-Synuclein amyloid assembly is suppressed by the binding of αB-crystallin to mature fibrils Waudby, C.A., Knowles, T.P.J., Devlin, G,L., Skepper, J.N., Ecroyd, H., Carver, J.A., Welland, M.E., Christodoulou, J., Dobson, C.M, Meehan S.
Wan S, Coveney PV. (2009) .A comparative study of the COX-1 and COX-2 isozymes bound to lipid membranes. J Comput Chem. 2009 May;30(7):1038-50.
Dr Martin Crompton [top]
Malouitre,S., Dube,H., Selwood,D., Crompton,M. (2009). Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation. Biochem J. ;425(1):137-48.
Professor Jasminka Godovac-Zimmerman [top]
Xu P, Crawford M, Way M, Godovac-Zimmermann J, Segal AW, Radulovic M. (2009)Subproteome analysis of the neutrophil cytoskeleton. Proteomics. 2009 Apr;9(7):2037-49.
Dr Bibek Gooptu [top]
Gooptu B, Miranda E, Nobeli I, Mallya M, Purkiss A, Brown SC, Summers C, Phillips RL, Lomas DA, Barrett TE.(2009) Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design. J Mol Biol. 387(4):857-68.
Gooptu B, Lomas DA. (2009) Conformational Pathology of the Serpins: Themes, Variations, and Therapeutic Strategies. Annu Rev Biochem. 2009 Feb 26. [Epub ahead of print]
Gwalter J, Wang ML, Gout I.(2009) The ubiquitination of ribosomal S6 kinases is independent from the mitogen-induced phosphorylation/activation of the kinase. Int J Biochem Cell Biol. 2009 Apr;41(4):828-33.
Fenton TR, Gwalter J, Ericsson J, Gout IT. (2009) Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo. Int J Biochem Cell Biol. 2009 Dec 2. [Epub ahead of print]
Mustapa MF, Grosse SM, Kudsiova L, Elbs M, Raiber EA, Wong JB, Brain AP, Armer HE, Warley A, Keppler M, Ng T, Lawrence MJ, Hart SL, Hailes HC, Tabor AB. (2009) Stabilized Integrin-Targeting Ternary LPD (Lipopolyplex) Vectors for Gene Delivery Designed To Disassemble Within the Target Cell. Bioconjug Chem. 20(3):518-532.
Dalby. P.A., Baganz,F.B., Hailes,H.C., Lye,G.J., Ward,J.M. (2009). Protein and pathway engineering in biocatalysis. Chemistry Today 27(4), 18-22.
Galman,J.L., Hailes,H.C. (2009). Application of a modified Mosher’s method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones. Tetrahedron: Asymmetry 20(15), 1828-1831.
Hailes,H.C., Dalby. P.A., Lye,G.J., Ward,J.M. (2009). Biocatalytic approaches to ketodiols and aminodiols. Chemistry Today 27(4), 28-31.
Ho,K.K., Rosivatz,E., Gunn,R.M., Smith,M.E.B., Stavropoulou,A.V., Rosivatz,E., Numbere,M.G., Wong,J.B., Lafitte,V.G.H., Behrendt,J.M., Myatt,S.S., Hailes,H.C., Woscholski,R., Lam,E.W.F. (2009). The novel molecule 2-(5-(2-chloroethyl)-2-acetoxy-benzyl)-4-(2-chloroethyl)-phenyl acetate inhibits Akt signalling through JNK activation in cancer cells. The FEBS Journal 276(15), 4037-4050.
Smithies,K., Smith,M.E.B., Kaulmann,U., Galman,J.L., Ward,J.M., Hailes,H.C. (2009). Stereoselectivity of an ω-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one. Tetrahedron: Asymmetry 20, 570-574.
Borsenberger,V., Howorka,S. (2009). Diene-modified nucleotides for the Diels-Alder-mediated functional tagging of DNA. Nucleic Acids Research 37(5):1477-85.
Mitchell,N., Schlapak,R., Kastner,M., Armitage,D., Chrzanowski,W., Riener,J., Hinterdorfer,P., Ebner,A., Howorka,S. (2009). A DNA nanostructure for the functional assembly of chemical groups with tunable stoichiometry and defined nanoscale geometry. Angewandte Chemie International Edition 48(3), 525-527.
Pollheimer,P.D, Kastner,M., Ebner,A., Blaas,D., Hinterdorfer,P., Gruber,H.J, Howorka,S. (2009). Receptor arrays for the selective and efficient capturing of viral particles. Bioconjugate Chemistry in press.
Schlapak,R., Armitage,D., Saucedo-Zeni,N., Chrzanowski,W., Hohage,M., Caruana,D., Howorka,S. (2009). Selective protein and DNA adsorption on PLL-PEG films modulated by ionic strength. Soft Matter 5(3), 613-621.
Papapostolou D, Howorka S. (2009) Engineering and exploiting protein assemblies in synthetic biology. Mol Biosyst. 5(7):723-32.
Borsenberger V, Mitchell N, Howorka S.(2009) Chemically labeled nucleotides and oligonucleotides encode DNA for sensing with nanopores. J Am Chem Soc. 2009 Jun 10;131(22):7530-1.
Zhu R, Ebner A, Kastner M, Preiner J, Howorka S, Hinterdorfer P (2009) .Topography and recognition imaging of protein-patterned surfaces generated by AFM nanolithography. Chemphyschem. 10(9-10):1478-81.
Leung C, Kinns H, Hoogenboom BW, Howorka S, Mesquida P. (2009) Imaging surface charges of individual biomolecules. Nano Lett. 2009 Jul;9(7):2769-73.
Howorka S, Siwy Z. (2009) Nanopore analytics: sensing of single molecules. Chem Soc Rev. 2009 Aug;38(8):2360-84. Epub 2009 Jun 15. Review.
Borsenberger V, Kukwikila M, Howorka S. (2009) Synthesis and enzymatic incorporation of modified deoxyuridine triphosphates. Org Biomol Chem. 2009 Sep 21;7(18):3826-35.
Kinns H, Badelt-Lichtblau H, Egelseer EM, Sleytr UB, Howorka S.(2009) Identifying Assembly-Inhibiting and Assembly-Tolerant Sites in the SbsB S-Layer Protein from Geobacillus stearothermophilus. J Mol Biol. 2009 Oct 15. [Epub ahead of print] .
Nugent, T. & Jones, D.T. (2009) Transmembrane protein topology prediction using support vector machines. BMC Bioinformatics. 10, 159. Epub.
Edwards, Y.J., Lobley, A., Pentony, M.M. & Jones, D.T. (2009) Insights into the regulation of intrinsically disordered proteins in the human proteome by analysing sequence and gene expression data. Genome Biol. 10, R50. Epub.
Lobley, A., Sadowski, M.I. & Jones, D.T. (2009) pGenTHREADER and pDomTHREADER: New Methods For Improved Protein Fold Recognition and Superfamily Discrimination. Bioinformatics. 25, 1761-1767.
Koussounadis, A., Redfern, O.C. & Jones, D.T. (2009) Improving classification in protein structure databases using text mining. BMC Bioinformatics. 10, 12. Sadowski, M.I. & Jones, D.T. (2009) The sequence-structure relationship and protein function prediction. Curr. Opin. Struct. Biol. Apr 28.
Sadowski, M.I. & Jones, D.T. (2009) An automatic method for assessing structural importance of amino acid positions. BMC Struct Biol. 9:10.
Lovett,J.E., Hoffmann,M., Cnossen,A., Shutter,A.T.J., Hogben,H.J., Warren,,J.E., Pascu,S.I., Kay,C.W.M., Timmel,C.R., Anderson,H.L. (2009). Probing Flexibility in Porphyrin-Based Molecular Wires Using Double Electron Electron Resonance. Journal of the American Chemical Society/ 131(38), 13852-13859
Mennenga,B., Kay,C.W.M.,Görisch,H. (2009). Quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa: the unusual disulfide ring formed by adjacent cysteine residues is essential for efficient electron transfer to cytochrome c550. Archives of Microbiology 191(4), 361-367.
Pirker,K.F., Kay,C.W.M., Stolze,K., Tunega,D., Reichenauer,T.G., Goodman,B.A. (2009). Free radical generation in rosmarinic acid investigated by electron paramagnetic resonance spectroscopy. Free Radical Research 43(1), 47-57.
Severino,J.F., Goodman,B.A., Kay,C.W.M., Stolze,K., Tunega,D., Reichenauer,T.G., Pirker,K.F. (2009). Free radicals generated during oxidation of green tea polyphenols: Electron paramagnetic resonance spectroscopy combined with density functional theory calculations. Free Radical Biology and Medicine 46(8)
Severino,J.F., Goodman,B.A., Kay,C.W.M., Stolze,K., Tunega,D., Reichenauer,T.G., Pirker,K.F. (2009). Free radicals generated during oxidation of green tea polyphenols: Electron paramagnetic resonance spectroscopy combined with density functional theory calculations. Free Radical Biology and Medicine 46(8), 1076-1088
Bagneris, C., Bateman, O.A., Naylor, C.E., Cronin, N., Boelens, W.C., Keep, N.H. & Slingsby, C. (2009.) Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20, J. Mol. Biol. , doi:10.1016/j.jmb.2009.07.069
Zhou J.J., Robertson G., He X., Dufour, S., Hooper A.M., Pickett, J.A., Keep, N.H. and Field, L.M. (2009). Characterisation of Bombyx mori Odorant-binding Proteins Reveals that a General Odorant-binding Protein Discriminates Between Sex Pheromone Components. J. Mol. Biol. 389, 529/545.
Kang, J.; Reynolds, N.L.; Tyrrell, C.; Dorin, J.R.; and Macmillan, D. Peptide thioester synthesis through N®S acyl-transfer: Application to the synthesis of a b-Defensin. Org. Biomol. Chem. 2009, 7, 4918-4923.
Hirano, K.; Macmillan, D.; Tezuka, K.; Tsuji, T.; Kajihara, Y. Design and synthesis of a homogeneous erythropoietin analogue having two human complex type sialyloligosaccharides by combined use of chemical and bacterial protein expression methods. Angew. Chem. Int. Ed. 2009, 48, 9557-9560.
Taylor, K.; Rolfe, M.; Kilanowski, F.; Pathania, U.; Reynolds, N.; Clarke, D.; Yang, D.; Oppenheim, J.; Samuel, K.; Howie, S.; Barran, P.; MacMillan, D.; Campopiano, D.; Dorin, J. Defr1 is allelic to Defb8 and is chemoattractant for dendritic cells and CD4 T cells but does not act through chemokine receptor 6. Eur. J. Immunol. 2009, 39(5), 1353-1360.
Kang, J.; Richardson, J.P.; Macmillan, D. 3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters, Chem. Commun. 2009 (4), 407-409.
Peh KH, Wan BY, Assem ES, Middleton JB, Dines J, Marson CM.(2009) Mode of action of histone deacetylase inhibitors on mast cell histamine release and colon muscle contraction. Inflamm Res. 2009 Apr;58 Suppl 1:24-5.
Assem ES, Peh KH, Wan BY, Dines J, Middleton BJ, Marson CM. (2009) Effects of a selection of histone deacetylase inhibitors on antigen- and agonist(s)-induced tracheal smooth muscle contraction. Inflamm Res. 2009 Apr;58 Suppl 1:22-3.
Marson CM(2009).Histone deacetylase inhibitors: design, structure-activity relationships and therapeutic implications for cancer. Anticancer Agents Med Chem. 2009 Jul;9(6):661-92. Review.
Assem ES, Mann S, Wan BY, Marson CM.(2009) Effect of antioxidants on airway smooth muscle contraction: action of lipoic acid and some of its novel derivatives on guinea pig tracheal smooth muscle. Inflamm Res. 2009 Dec 15. [Epub ahead of print]
Wan BY, Mann S, Assem ES, Marson CM.(2009).Effect of endogenous and synthetic antioxidants on hydrogen peroxide-induced guinea-pig colon contraction. Inflamm Res. 2009 Dec 23. [Epub ahead of print]
Dr Andrew Martin [top] Hurst JM, McMillan LE, Porter CT, Allen J, Fakorede A, Martin AC.(2009)The SAAPdb web resource: a large-scale structural analysis of mutant proteins. Hum Mutat. 2009 Apr;30(4):616-24.
Izarzugaza, J.M.G., Baresic, A., McMillan, L.E.M., Yeats, C., Clegg, A., Orengo, C.A., Martin, A.C.R. and Valencia, A. (2009) An integrated approach to the interpretation of Single Amino Acid Polymorphisms within the framework of CATH and Gene3D. BMC Bioinformatics. 10 Suppl 8, S5-S5.
Roffey J, Rosse C, Linch M, Hibbert A, McDonald NQ, Parker PJ. (2009)Protein kinase C intervention: the state of play. Curr Opin Cell Biol. (2009) Apr;21(2):268-79.
Kostelecky B, Saurin AT, Purkiss A, Parker PJ, McDonald NQ. (2009) Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. EMBO Reports (2009) 10(9), 983-989.
Bodey AJ, Kikkawa M, Moores CA.(2009) 9-Angström structure of a microtubule-bound mitotic motor. J Mol Biol. 388(2):218-24.
Mulder AM, Glavis-Bloom A, Moores CA, Wagenbach M, Carragher B, Wordeman L, Milligan RA. (2009) A new model for binding of kinesin 13 to curved microtubule protofilaments. J Cell Biol. 185(1):51-7.
Bolchini D, Finkelstein A, Perrone V, Nagl S (2009) Better bioinformatics through usability analysis. Bioinformatics. 2009 Feb 1;25(3):406-12. Epub 2008 Dec 9.
Yong M, Tolner B, Nagl S, Pedley RB, Chester K, Green AJ, Mayer A, Sharma S, Begent R.(2009) Data standards for minimum information collection for antibody therapy experiments. Protein Eng Des Sel. 2009 Mar;22(3):221-4.
Macchiarulo, A., Thornton, J.M., Nobeli, I. (2009). Mapping human metabolic pathways in the small molecule chemical space. J. Chem. Inf. Model., 49, 2272.
Gooptu, B., Miranda, E., Nobeli, I., Mallya, M., Purkiss, A., Brown, S.C., Summers, C., Phillips, R.L., Lomas, D.A., Barrett, T.E. (2009). Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design. J. Mol. Biol., 387, 857.
Nobeli, I., Favia, A., and Thornton, J.M. (2009). Protein promiscuity and its implications for the exploitation of biotechnology. Nat. Biotechnol., 27, 157-167.
Hunter S, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bork P, Das U, Daugherty L, Duquenne L, Finn RD, Gough J, Haft D, Hulo N, Kahn D, Kelly E, Laugraud A, Letunic I, Lonsdale D, Lopez R, Madera M, Maslen J, McAnulla C, McDowall J, Mistry J, Mitchell A, Mulder N, Natale D, Orengo C, Quinn AF, Selengut JD, Sigrist CJ, Thimma M, Thomas PD, Valentin F, Wilson D, Wu CH, Yeats C.(2009) InterPro: the integrative protein signature database. Nucleic Acids Res. 2009 Jan;37(Database issue):D211-5. Epub 2008 Oct 21.
Dessailly BH, Redfern OC, Cuff A, Orengo CA.(2009) Exploiting structural classifications for function prediction: towards a domain grammar for protein function. Curr Opin Struct Biol. 2009 Jun;19(3):349-56. Epub 2009 Apr 22. Review.
Dessailly BH, Reid AJ, Yeats C, Lees JG, Cuff A, Orengo CA.(2009) The evolution of protein functions and networks: a family-centric approach. Biochem Soc Trans. 2009 Aug;37(Pt 4):745-50.
Redfern OC, Dessailly BH, Dallman TJ, Sillitoe I, Orengo CA.(2009) FLORA: a novel method to predict protein function from structure in diverse superfamilies. PLoS Comput Biol. 2009 Aug;5(8):e1000485. Epub 2009 Aug 28.
Kahlem P, Clegg A, Reisinger F, Xenarios I, Hermjakob H, Orengo C, Birney E.(2009) ENFIN--A European network for integrative systems biology. C R Biol. 2009 Nov;332(11):1050-8
Cuff, A.L. et al. The CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamilies. Nucleic Acids Res 37, D310-4 (2009).
Cuff, A.L. et al, The CATH hierarchy revisited – structural divergence in domain superfamilies and the continuity of fold space. Structure 17(8), 1051-1062 (2009)
Dessailly, B. & Orengo, C. Functional Diversity WIthin Folds and Superfamilies. in From Protein Structure To Function with Bioinformatics (Springer-London, 2009).
Dessailly BH, Nair R, Jaroszewski L, Fajardo JE, Kouranov A, Lee D, Fiser A, Godzik A, Rost B, Orengo C. PSI-2: structural genomics to cover protein domain family space. Structure. 2009 Jun 10;17(6):869-81
Jose M. G. Izarzugaza, Anja Baresic, Lisa E. M. McMillan, Corin Yeats, Andrew B. Clegg, Christine A. Orengo, Andrew C. R. Martin and Alfonso Valencia, ”An integrated approach to the interpretation of Single Amino Acid Polymorphisms within the framework of CATH and Gene3D”, in BMC Bioinformatics 10 (Suppl 8):S5 (2009).
Lee, D., Rentzsch, R. & Orengo, C. GEMMA:Identifying Functional Sub-Families in CATH Superfamilies. Nucleic Acids Res 38, 720-737 (2009).
Loewenstein, Y et al. Protein function annotation by homology-based inference. Genome Biol 10, 207 (2009). Maratou, K. et al. Comparison of dorsal root ganglion gene expression in rat models of traumatic and HIV-associated neuropathic pain. Eur J Pain 13, 387-98 (2009).
Renata Kabiljo, Andrew B. Clegg and Adrian J. Shepherd, ”A realistic assessment of methods for extracting gene/protein interactions from free text”, in BMC Bioinformatics 10:233 (2009).
Ranea, J.A., Reid, A., Yeats, C. & Orengo, C.A. Study of the Dark Matter in Protein Network Prediction and Modelling. PLoS Comp. Biol. In Revision. (2009).
Reid, A., Ranea, J.A. & Orengo, C. Comparative Evolutionary Analysis of Complexes in E.Coli and Yeast. BMC Genomics. In Press. (2009).
Reid, A., Ranea, J.A. & Orengo, C. CODA: Accurate detection of functional associations by domain fusion in higher eukaryoytes. BMC Genomics Genomics. In Press (2009).
Rentzsch, R., Orengo, C.A. Protein function prediction - the power of multiplicity. Trends Biotechnol. 2009 Apr;27(4):210-9.
Yeats, C., Lees, J., Redfern, O.,Clegg, A., and Orengo, C ”Gene3D: Merging Structure and Function For a Thousand Genomes”, in Nucleic Acids Research (2009).
Yeats, C., Redfern, O. & Orengo, C. A fast and automated solution for accurately resolving protein domain architectures. Bioinformatics. In Press. (2009).
Fronzes R, Schäfer E, Wang L, Saibil HR, Orlova EV, Waksman G. (20090 Structure of a type IV secretion system core complex. Science.323(5911):266-8.
Okorokov AL, Orlova EV.(2009) Structural biology of the p53 tumour suppressor. Curr Opin Struct Biol. 2009 Apr;19(2):197-202.
White HE, Hodgkinson JL, Jahn TR, Cohen-Krausz S, Gosal WS, Müller S, Orlova EV, Radford SE, Saibil HR. (2009) Globular Tetramers of beta(2)-Microglobulin Assemble into Elaborate Amyloid Fibrils. J Mol Biol. 2009 Apr 5. [Epub ahead of print]
Orlova EV. (2009) How viruses infect bacteria? EMBO J. 28(7):797-8.
Lhuillier S, Gallopin M, Gilquin B, Brasil s S, Lancelot N, Letellier G, Gilles M, Dethan G, Orlova EV, Couprie J, Tavares P, Zinn-Justin S. (2009) Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating. Proc Natl Acad Sci USA. 106(21), 8507-8512.
Professor Steve Perkins [top] Bonner,A., Almogren,A., Furtado,P. B., Kerr,M. A., Perkins,S.J. (2009). Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity. Mucosal Immunology 2, 74-84
Bonner,A., Almogren,A., Furtado,P. B., Kerr,M. A., Perkins,S.J. (2009). The non-planar secretory IgA2 and near-planar secretory IgA1 solution structures rationalize their different mucosal immune responses. Journal of Biological Chemistry 284, 5077-5087.
Leonard,P. G., Ono,S., Gor,J., Perkins,S. J., Ladbury,J. E. (2009). Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria. Molecular Microbiology 73, 165-179.
Okemefuna,A. I., Li,K., Nan,R., Ormsby,R. J., Sadlon,T., Gordon,D. L., Perkins,S. J. (2009). Multimeric interactions between complement Factor H and its C3d ligand provide new insight on complement regulation. Journal of Molecular Biology 391, 119-135.
Okemefuna,A. I., Nan,R., Gor,J., Perkins,S. J. (2009). Electrostatic interactions contribute to the folded-back conformation of wild-type human Factor H. Journal of Molecular Biology 391, 98-118.
Perkins,S. J., Okemefuna,A. I., Nan,R., Li,K., Bonner,A. (2009). Constrained solution scattering modelling of human antibodies and complement proteins reveals novel biological insights. Journal of the Royal Society Interface .
Perkins,S.J. (2009). Unravelling antibody and complement structures in immunity using TS-2 neutrons at ISIS: Neutron scattering. The Biochemist 31(4), 32-35
Saunders,R.E., Shiltagh,N., Gomez,K., Mellars,G., Cooper,C., Perry,D.J., Tuddenham,E.G., Perkins,S.J. (2009). Structural analysis of eight novel and 111 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency. Thrombosis and Haemostasis 102(2), 183-420.
Castleman,V.H., Romio,L., Chodhari,R., Hirst,R.A., de Castro,S.C., Parker,K.A., Ybot-Gonzalez,P., Emes,R.D., Wilson,S.W., Wallis,C., Johnson,C.A., Herrera,R.J., Rutman,A., Dixon,M., Shoemark,A., Bush,A., Hogg,C., Gardiner,R.M., Reish,O., Greene,N.D.,O\'Callaghan,C., Purton,S., Chung,E.M., Mitchison,H.M. (2009). Mutations in Radial Spoke Head Protein Genes RSPH9 and RSPH4A Cause Primary Ciliary Dyskinesia with Central-Microtubular-Pair Abnormalities. The American Journal of Human Genetics 84(2), 197-209.
Maréchal,A., Kido,Y., Kita,K., Moore,A.L., Rich,P.R. (2009). Three redox states of Trypanosoma brucei alternative oxidase identified by infrared spectroscopy and electrochemistry. Journal of Biological Chemistry 284, 31827-31833.
Marshall,D., Rich,P.R. (2009). Studies of complex I by Fourier transform infrared spectroscopy. Methods in Enzymology 456, 53-74.
Whitehead,S.J., Iwaki,M., Cotton,N.P.J., Rich,P.R., Jackson,J.B. (2009). Inhibition of proton transfer steps in transhydrogenase by metal ions. Biochim. Biophys. Acta 1787, 1276-1288
Clare DK, Bakkes PJ, van Heerikhuizen H, van der Vies SM, Saibil HR. (2009) Chaperonin complex with a newly folded protein encapsulated in the folding chamber. Nature. 457(7225):107-10.
Wendler P, Shorter J, Snead D, Plisson C, Clare DK, Lindquist S, Saibil HR. (2009) Motor mechanism for protein threading through Hsp104. Mol Cell. 34(1):81-92.
Fronzes R, Schäfer E, Wang L, Saibil HR, Orlova EV, Waksman G. (20090 Structure of a type IV secretion system core complex. Science.323(5911):266-8.
White HE, Hodgkinson JL, Jahn TR, Cohen-Krausz S, Gosal WS, Müller S, Orlova EV, Radford SE, Saibil HR. (2009) Globular Tetramers of beta(2)-Microglobulin Assemble into Elaborate Amyloid Fibrils. J Mol Biol. 389(1):48-57.
Tarry MJ, Schäfer E, Chen S, Buchanan G, Greene NP, Lea SM, Palmer T, Saibil HR, Berks BC. (2009) Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system. Proc Natl Acad Sci U S A. 106(32):13284-9.
Malouitre,S., Dube,H., Selwood,D., Crompton,M. (2009). Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation. Biochemical Journal. 425(1):137-48.
Allerston,C.A., Vetti,H.H., Houge,G., Phillips,I.R., Shephard,E.A. (2009). A novel mutation in the flavin-containing monooxygenase 3 gene (FMO3) of a Norwegian family causes trimethylaminuria. Molecular Genetics and Metabolism 98, 198-202.
Francois,A.A., Nishida,C.R., OrtizdeMontellano,P.R., Phillips,I.R., Shephard,E.A. (2009). Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide. Drug Metabolism and Disposition 37(10), 178-186.
Hernandez,D., Chandan,P., Janmohamed,A., Omar,B., Phillips,I.R., Shephard,E.A (2009). Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine. Pharmacogenetics and Genomics 19(4), 289-299.
Kaput,J. Cotton,R., Hardman,L. Shephard,E. et al (2009). Planning the Human Variome Project: The Spain Report. Human Mutation 34(4), 496-510. Dr Adrian Shepherd [top]
Halling-Brown MD, Moss DS, Sansom CE, Shepherd AJ. (2009) A computational Grid framework for immunological applications. Philos Transact A Math Phys Eng Sci. 367(1898):2705-16.
Kabiljo R, Clegg AB, Shepherd AJ. (2009) A realistic assessment of methods for extracting gene/protein interactions from free text. BMC Bioinformatics. 10:233.
Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20. C. Bagneris, O.A. Bateman, C.E. Naylor, N. Cronin, W.C. Boelens, N.H. Keep and C. Slingsby. (2009) J. Mol. Biol. 392: 1242-1252
Gambling L, Czopek A, Andersen HS, Holtrop G, Srai SK, Krejpcio Z, McArdle HJ. (2009) Fetal iron status regulates maternal iron metabolism during pregnancy in the rat. Am J Physiol Regul Integr Comp Physiol. 296(4):R1063-70.
Chambers JC, Zhang W, Li Y, Sehmi J, Wass MN, Zabaneh D, Hoggart C, Bayele H, McCarthy MI, Peltonen L, Freimer NB, Srai SK, Maxwell PH, Sternberg MJ, Ruokonen A, Abecasis G, Jarvelin MR, Scott J, Elliott P, Kooner JS. (2009) Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nat Genet. 2009 Nov;41(11):1170-2.
Bayele HK, Srai SK. (2009) Genetic variation in hepcidin expression and its implications for phenotypic differences in iron metabolism. Haematologica. Sep;94(9):1185-8. Review.
Chung B, Chaston T, Marks J, Srai SK, Sharp PA. (2009) Hepcidin decreases iron transporter expression in vivo in mouse duodenum and spleen and in vitro in THP-1 macrophages and intestinal Caco-2 cells. J Nutr.Aug;139(8):1457-62.
Ward RJ, Wilmet S, Legssyer R, Leroy D, Toussaint L, Crichton RR, Pierreux C, Hue L, Piette J, Srai SK, Solanky N, Klein D, Summer K. (2009) Effects of marginal iron overload on iron homeostasis and immune function in alveolar macrophages isolated from pregnant and normal rats. Biometals. 2009 Apr;22(2):211-23.
Mustapa MF, Grosse SM, Kudsiova L, Elbs M, Raiber EA, Wong JB, Brain AP, Armer HE, Warley A, Keppler M, Ng T, Lawrence MJ, Hart SL, Hailes HC, Tabor AB. (2009) Stabilized Integrin-Targeting Ternary LPD (Lipopolyplex) Vectors for Gene Delivery Designed To Disassemble Within the Target Cell. Bioconjug Chem. 20(3):518-532. v
Siddiqui R, Syed A, Tomas S, Prieto-Garcia J, Khan NA.(2009) Effect of free versus liposomal-complexed pentamidine isethionate on biological characteristics of Acanthamoeba castellanii in vitro. J Med Microbiol. 58(Pt 3):327-30.
Tomas S, Milanesi L. (2009) Hydrophobically self-assembled nanoparticles as molecular receptors in water. J Am Chem Soc. 131(18):6618-23.
Dr Maya Topf [top]
Lasker K, Topf M, Sali A, Wolfson HJ. (2009) Inferential optimization for simultaneous fitting of multiple components into a CryoEM map of their assembly. J Mol Biol. 388(1):180-94.
Taylor DJ, Devkota B, Huang AD, Topf M, Narayanan E, Sali A, Harvey SC, Frank J.(2009) Comprehensive molecular structure of the eukaryotic ribosome. Structure. 17(12):1591-604.
Gospodinov A, Tsaneva I, Anachkova B. (2009) RAD51 foci formation in response to DNA damage is modulated by TIP49. Int J Biochem Cell Biol. 41(4):925-33.
Vaughan CK, Piper PW, Pearl LH, Prodromou C.(2009) A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s. FEBS J. 276(1):199-209
A.Toste Rego, V. Chandran and G.Waksman* (2009). Two-step and one-step secretion mechanisms in Gram-negative bacteria: contrasting the type IV secretion system and the chaperone-usher pathway of pilus biogenesis. Biochem J. 425:475 - 488.
V. Chandran, R. Fronzes, S. Duquerroy, N. Cronin, J. Navaza, and G. Waksman* (2009). Crystal structure of the outer membrane complex of a type IV secretion system. Nature. 462:1011-1015.
R. Kenjale, G. Meng, D. Fink, T. Juehne, T. Ohashi, H. Erickson, G. Waksman, and J. St Geme 3rd * (2009). Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter. Infect Immun. 77:4704-4713
G. Waksman* and S.J. Hultgren* (2009). Structure and assembly mechanism of chaperone-usher pili. Nature Reviews Microbiology. 7:703-714. R. Fronzes, P. Christie*, and G. Waksman* (2009). Structural insights into type IV secretion machineries. Nature Reviews Microbiology. 7:703-714.
E. Durand, D. Verger, A. Toste-Rego, V. Chandran, G. Meng, R. Fronzes, G. Waksman (2009). Structural biology of bacterial secretion sytems in Gram-negative pathogens – Potential for new drug targets. Infectious Disorders - drug targets. 9:518-547.
J. Radin, S. Grass, G. Meng, S. Cotter, G. Waksman, and J. St Geme 3rd* (2009). Structural basis for the differential binding affinities of the HsfBD1 and HsfBD2 domains in the Haemophilus influenzae Hsf adhesin. J. Bacteriology. 191:5068-5075
G. Waksman* (2009). Going round in circles: the structural biology of type III secretion systems. Nature Structural and Molecular Biology. 16: 459-460.
R. Fronzes, E. Schaefer, L. Wang, H. Saibil, E. Orlova and G. Waksman* (2009). Structure of type IV secretion core complex. Science. 323:266-268.
G. Meng, R. Fronzes, V. Chandran, H. Remaut, and G. Waksman* (2009). Protein oligomerization in the bacterial outer membrane. Molecular Membrane Biology. 26:136-145.
Drechsler A, Miles AJ, Norton RS, Wallace BA, Separovic F.(2009) Effect of lipid on the conformation of the N-terminal region of equinatoxin II: a synchrotron radiation circular dichroism spectroscopic study. Eur Biophys J. 39(1):121-7.
Charalambous K, O'Reilly AO, Bullough PA, Wallace BA. (2009) Thermal and chemical unfolding and refolding of a eukaryotic sodium channel. Biochim Biophys Acta. 1788(6):1279-86. s
Dalby. P.A., Baganz,F.B., Hailes,H.C., Lye,G.J., Ward,J.M. (2009). Protein and pathway engineering in biocatalysis. Chemistry Today 27(4), 18-22.
Hailes,H.C., Dalby. P.A., Lye,G.J., Ward,J.M. (2009). Biocatalytic approaches to ketodiols and aminodiols. Chemistry Today 27(4), 28-31.
Schell,U., Wohlgemuth,R., Ward,J.M. (2009). Synthesis of pyridoxamine 5’-phosphate using an MBA:pyruvate transaminase as biocatalyst. Journal of Molecular Catalysis B: Enzymatic 59(4), 279-285.
Smithies,K., Smith,M.E.B., Kaulmann,U., Galman,J.L., Ward,J.M., Hailes,H.C. (2009). Stereoselectivity of an ω-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one. Tetrahedron: Asymmetry 20, 570-574.
Balasundaram B, Nesbeth D, Ward JM, Keshavarz-Moore E, Bracewell DG. (2009) Step change in the efficiency of centrifugation through cell engineering: co-expression of Staphylococcal nuclease to reduce the viscosity of the bioprocess feedstock. Biotechnol Bioeng. 104:134-42.
Dina Grohmann, Angela Hirtreiter and Finn Werner (2009). Molecular Mechanisms of Archaeal RNA polymerase. Biochemical Society Transactions 37, 12-17.
Dina Grohmann, Angela Hirtreiter and Finn Werner (2009). The RNAP subunits F/E (RPB4/7) are stably associated with archaeal RNA polymerase - using fluorescence anisotropy to monitor RNAP assembly in vitro. Biochemical Journal 421(3), 339-343.
Sanjay Nilapwar, Eleanor P. Smith, Christopher Fu, Christomos Prodromou, Laurence H. Pearl, Mark A. Williams and John E. Ladbury (2009). Structural-thermodynamics relationships of interactions in the N-terminal ATP binding domain of Hsp90. J. Mol. Biol. 392, 923-936.
Gill,R., Kolstoe,S.E., Mohammed,F., Al D-Bass,A., Mosely,J.,E., Sarwar,M., Cooper,J.B., Wood,S.P., Shoolingin-Jordan,P.M. (2009). Structure of human porphobilinogen deaminase at 2.8 A: the molecular basis of acute intermittent porphyria. Biochemical Journal 420, 17-25.
Kolstoe,S.E., Ridha,B.H., Bellotti,V., Wang,N., Robinson,C.V., Crutch,S.J., Keir,G., Kukkastenvehmas,R., Gallimore,J.R., Hutchinson,W.L., Hawkins,P.N., Wood,S.P., Rossor,M.N., Pepys,M.B. (2009). Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component. Proceedings of the National Academy of Sciences of the United States of America 106(18), 7619-7623.
Zhou,L., Li,J., George,R., Ruchaud,S., Zhou,H., Ladbury,J.E., Earnshaw,W.C., Yuan,X. (2009). Effects of Full-Length Borealin on the Composition and Protein-Protein Interaction Activity of a Binary Chromosomal Passenger Complex. Biochemistry 48(6), 1156-1161.
Institute of Structural Molecular Biology, University of London
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