ISMB member publications in 2005


Dr Tracey Barrett [top]

Not yet available


Dr Sanjib Bhakta [top]

Westwood IM, Holton SJ, Rodrigues-Lima F, Dupret JM, Bhakta S, Noble ME, Sim E. (2005). Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase. Biochem J. 385(Pt 2):605-12.

Professor Jeremy Brockes [top]

Duckmanton A, Kumar A, Chang Y-T, Brockes JP. (2005). A single cell analysis of myogenic dedifferentiation induced by small molecules. Chemistry & Biology. 12(10), 1117-1125.

Brockes JP and Kumar A. (2005). Appendage regeneration in adult vertebrates and implications for regenerative medicine, Science. 310, 1919-1923.

Professor Steve Caddick

P. Vallance, H. D. Bush, B. J. Mok, R. Hurtado-Guerrero, H. Gill, S. Rossiter, J. D. Wilden, S. Caddick (2005). Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates. Chem. Commun. 5563 - 5565.

J. Wilden, D. B. Judd, S. Caddick (2005). Rate enhancement of PFP sulfonate ester aminolysis by chloride salts in organic and aqueous media. Tetrahedron Lett. 46, 7637 7640.

N. R. Treweeke, P. B. Hitchcock, D. Pardoe, S. Caddick (2005). Controlling diastereoselectivity in the reactions of enantiomerically pure a-bromoacyl-imidazolidinones with nitrogen nucleophiles. Substitution reactions with retention or inversion of configuration. Chem Commun . 1868 1870.

K. Arentsen,S. Caddick, F. G. N. Cloke (2005) . On the efficiency of two-coordinate palladium (0) N-heterocyclic carbene complexes in amination and S uzuki-Miyaura reactions of aryl chlorides.  Tetrahedron. 61, 9710-9715 .

S. Caddick, J. D. Wilden, D. B. Judd (2005). Observations on the reactivity of pentafluorophenylsulfonate esters. Chem Commun. 2727-2728.

I. Conesa Lerma, M. J. Cawley, F. G. N. Cloke, K. Arentsen, J. S. Scott, S. E. Pearson, J. Hayler, S. Caddick (2005). Studies on Pd/imidazolium salt protocol for amination of aryl bromides and iodides using lithium hexamethyldisilazide (LHMDS). J. Organomet. Chem. 690, 5841 5848.

Professor Richard Catlow [top]

Blanchard M, Alfredsson M, Brodholt J, Price GD, Wright K, Catlow CR. (2005). Electronic structure study of the high-pressure vibrational spectrum of FeS2 pyrite. J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 109(46):22067-73.

Gomez-Hortiguela L, Perez-Pariente J, Cora F, Catlow CR, Blasco T. (2005). Structure-directing role of molecules containing benzyl rings in the synthesis of a large-pore aluminophosphate molecular sieve: an experimental and computational study. J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 109(46):21539-48.

Hamad S, Catlow CR, Woodley SM, Lago S, Mejias JA. (2005). Structure and stability of small TiO2 nanoparticles. J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 109(33):15741-8.

Hamad S, Catlow CR, Spano E, Matxain JM, Ugalde JM. (2005). Structure and properties of ZnS nanoclusters. J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 109(7):2703-9.

Sayle TX, Catlow CR, Maphanga RR, Ngoepe PE, Sayle DC. (2005). Generating MnO2 nanoparticles using simulated amorphization and recrystallization. J Am Chem Soc. 127(37):12828-37.

Phala NS, Klatt G, van Steen E, French SA, Sokol AA, Catlow CR. (2005). The nature of the oxidation states of gold on ZnO. Phys Chem Chem Phys. 7(12):2440-5.

Catlow CR, French SA, Sokol AA, Thomas JM. (2005). Computational approaches to the determination of active site structures and reaction mechanisms in heterogeneous catalysts. Philos Transact A Math Phys Eng Sci. 363(1829):913-36; discussion 1035-40. Review.

To J, Sokol AA, French SA, Kaltsoyannis N, Catlow CR (2005). Hole localization in [AlO4]0 defects in silica materials. J Chem Phys. 122(14):144704.

Mora-Fonz MJ, Catlow CR, Lewis DW. (2005). Oligomerization and cyclization processes in the nucleation of microporous silicas. Angew Chem Int Ed Engl. 44(20):3082-6.

Hamad S, Cristol S, Catlow CR. (2005). Simulation of the embryonic stage of ZnS formation from aqueous solution. J Am Chem Soc. 2;127(8):2580-90.

Professor Peter Coveney

J. Harting, M. J. Harvey, J. Chin and P. V. Coveney, "Detection and tracking of defects in the gyroid mesophase", Comp. Phys. Commun., 165, Issue 2, 97-109, (2005), DOI: 10.1016/j.cpc.2004.10.001.

Dr Andrew Dingley [top]

Dingley AJ, Peterson RD, Grzesiek S, Feigon J. (2005). Characterization of the cation and temperature dependence of DNA quadruplex hydrogen bond properties using high-resolution NMR. J Am Chem Soc. 127(41):14466-72.

van Mourik T, Dingley AJ. (2005). Characterization of the monovalent ion position and hydrogen-bond network in guanine quartets by DFT calculations of NMR parameters. Chemistry. 11(20):6064-79.

Dr Snezana Djordjevic [top]

Nunn CM, Jeeves M, Cliff MJ, Urquhart GT, George RR, Chao LH, Tscuchia Y, Djordjevic S. (2005) Crystal structure of tobacco etch virus protease shows the protein C terminus bound within the active site. J Mol Biol. 350:145-55.

Sardiwal S, Kendall SL, Movahedzadeh F, Rison SCG, Stoker NG, Djordjevic S. (2005) A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem J Mol Biol. in press.

Dr Paul Driscoll [top]

H. N. Murphy, G.R. Stewart, V. V. Mischenko, A. S. Apt, R. Harris, M. S. McAlister, P. C. Driscoll, D. B. Young, B. D. Robertson (2005). The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosis J. Biol. Chem. 280, 14524-14529.

Professor Jasminka Godovac-Zimmerman [top]

Drukier AK, Ossetrova N, Schors E, Brown LR, Tomaszewski J, Sainsbury R, Godovac-Zimmermann J. (2005) Ultra-sensitive immunoassays using multi-photon-detection in diagnostic proteomics of blood. Journal of Proteome Research . 4(6): p.2375-8.

Godovac-Zimmermann J, Kleiner O, Brown LR and Drukier AK (2005). Perspectives in Spicing Up Proteomics with Splicing. Proteomics. 5(3):699-709

Guerrera IC, Predic-Atkinson J, Kleiner O, Soskic V, Godovac-Zimmermann J.(2005). Enrichment of phosphoproteins for proteomic analysis using immobilized Fe(III)-affinity adsorption chromatography. J. Proteom. Res. 4(5):1545-53.

Kleiner O and Godovac-Zimmermann J. (2005) Proteomics of Signal Transduction Pathways. in "Signaling Pathways in Liver Diseases". Eds Dufour J-F and Clavien P-A. Springer-Verlag GmbH, Heidelberg pp 417-431.

Kleiner, O., Price, D. A., Ossetrova, N., Osetrov, S., Volkovitsky, P., Drukier, A. K., and Godovac-Zimmermann, J. (2005) . Ultra-high sensitivity multi-photon detection imaging in proteomics analyses. Proteomics. 5(9):2322-30.

Shakib K, Norman JT, Fine LG, Brown LR, Godovac-Zimmermann J.  (2005) . Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Proteomics. 5(11):2819-38.

Dr Helen Hailes[top]

J. Behrendt, H. C. Hailes, K. Bala, P. Golding. Oxetane synthesis via Cyclisation of Aryl Sulfonate Esters on Polystyrene and PEG Polymeric Supports. Tetrahedron Lett. 2005, 46, 643-645.

P. A. Dalby, H. C. Hailes, J. Ward, J. M. Woodley, E. Hibbert, F. Baganz, and G. Lye (2005). Directed evolution of biocatalytic processes. Biomolecular Engineering. 22, 11-19.

V. G. H. Lafitte, A. Aliev, H. C. Hailes, K. Bala, and P. Golding (2005). Ureidopyrimidinones Incorporating a Functionalisable p-Aminophenyl Electron-Donating Group at C-6. J.Org. Chem. 70, 2701 – 2707.

S. Sarkar, L. K. Lee, S. L. Hart, H. C. Hailes, S. M. Levy, A. B. Tabor and P. Azayi Shamlou (2005). Fractal Structure of Polycation-DNA Complexes. Biotech. Appl. Biochem. 41, 127-136.

P. Caumul and H. C. Hailes (2005). Baylis-Hillman Reactions in Aqueous Acidic Media. Tetrahedron Lett. 46, 8125-8127.

K. Bala and H. C. Hailes (2005). Nitrile Oxide 1,3-Dipolar Cycloadditions in Water: Novel Isoxazoline and Cyclophane Synthesis. Synthesis. 3423-3427.

Professor Karl Hale [top]

Karl J. Hale, Mathias M. Domostoj, Mohamed El-Tanani. F. Charles Campbell, and Charlene K. Mason. (2005) Total Synthesis and Mechanism of Action Studies on the Antitumor Alkaloid (-)-Agelastatin A Strategies and Tactics in Organic Synthesis Vol. 6, Ed. M. Harmata Chapter 11, 352-394.

Dimopoulos P, George J, Tocher DA, Manaviazar S, Hale KJ. (2006) Mechanistic studies on the O-directed free-radical hydrostannation of disubstituted acetylenes with Ph3SnH and Et3B and on the iodination of allylically oxygenated alpha-triphenylstannylalkenes. Org Lett. 7(24):5377-80.

Dimopoulos P, Athlan A, Manaviazar S, Hale KJ. (2006) On the stereospecific conversion of proximally-oxygenated trisubstituted vinyltriphenylstannanes into stereodefined trisubstituted alkenes. Org Lett. 7(24):5373-6.

Dimopoulos P, Athlan A, Manaviazar S, George J, Walters M, Lazarides L, Aliev AE, Hale KJ. (2006) O-Directed free-radical hydrostannations of propargyl ethers, acetals, and alcohols with Ph3SnH and Et3B. Org Lett. 7(24):5369-72.

Professor Elizabeth Hounsell [top]

Not yet available

Dr Stefan Howorka [top]

Pammer, P., R. Schlapak, M. Sonnleitner, R. Zhu, P. Hinterdorfer, O. Höglinger, H. Schindler, S. Howorka (2005). Nanopatterning of biomolecules with microscale beads. ChemPhysChem 6 (5) 900-903.

Professor David Jones

Bryson, K., McGuffin, L. J., Marsden, R. L., Ward, J. J., Sodhi, J. S. & Jones, D. T. (2005). Protein structure prediction servers at University College London. Nucleic Acids Research 33(Web Server issue):W36-38

Lise, S., & Jones, D. T. (2005). Sequence patterns associated with disordered regions in proteins. Proteins: Structure, Function and Genetics 58, 144-150.

Dr Cristopher Kay [top]

Kay, C. W. M., Schleicher, E., Hitomi, K., Todo, T., Bittl, R. and Weber, S.(2005) Determination of the G-Matrix Orientations in Flavin Radicals by High-Field/High-Frequency Electron-Nuclear Double Resonance. Magnetic Resonance in Chemistry. 43, S96-S102

Weber, S., Kay, C. W. M., Bacher, A., Richter, G. and Bittl, R. (2005) Probing the N(5)-H Bond of the Isoalloxazine Moiety of Flavin Radicals by 9 GHz and 94 GHz Pulsed Electron-Nuclear Double Resonance. ChemPhysChem. 6, 292-299.

Kay, C. W. M., Bittl, R., Bacher, A., Richter, G. and Weber, S. (2005) Unambiguous determination of the g-matrix orientation in a neutral flavin radical by pulsed electron-nuclear double resonance at 94 GHz. Journal of the American Chemical Society. 127, 10780-10781.

Kay, C. W. M., Mennenga, B., Görisch, H. and Bittl, R. (2005). Substrate-binding in quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa studied by electron paramagnetic resonance at 94 GHz. Journal of the American Chemical Society. 127, 7974-7975.

Dr Nick Keep[top]

Kennaway CK, Benesch JLP, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR and Keep NH. (2005). Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J.Biol. Chem. 280, 33419-33425.

Cohen-Gonsaud M, Barthe P, Bagnéris C, Henderson B, Ward J, Roumestand C and Keep NH. (2005). The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes. Nature Structural and Molecular Biology. 12(3):270-3.


Professor John Ladbury [top]

Cliff, M. J., Williams, M. A., Brooke-Smith, J., Barford, D. & Ladbury, J. E. (2005). Molecular recognition via coupled folding and binding in a TPR domain. Journal of Molecular Biology. 346, 717-732.

Ladbury, J. E. (2005). Protein-protein recognition in phosphotyrosine-mediated intracellular signaling. In: Protein Reviews Volume 3 (Dr. Zouhair Atassi, Series Editor) : "Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics and Drug Design". Editor G. Waksman. Kluwer/Plenum Publishing Corporation. New York, USA. ISBN 0-387-24531-6. pp. 165-184 .

Ono, S., Goldberg M. D., Olsson, T., Esposito, D., Hinton, J. C. D., & Ladbury, J. E. (2005). H-NS is a part of a thermally controlled mechanism for bacterial gene regulation. Biochemical Journal. 391, 203-213.

Taylor, J. D., Fawaz, R. R., Ababou, A., Williams, M. A., & Ladbury, J. E. (2005). NMR assignment of the apo and peptide-bound SH2 domain from the Rous sarcoma viral protein Src. Journal of Biomolecular NMR. 32, 339.

Yang, J., Roe, S. M., Cliff, M. J., Williams, M. A., Ladbury, J. E. & Barford, D. (2005). Structure of auto-inhibited protein phosphatase 5 reveals mechanism of TPR-mediated enzyme regulation.  EMBO Journal. 21, 1-10.

Erra, E., Petraccone, L., Esposito, V., Randazzo, A., Mayol, L., Ladbury, J., Barone, G., Giancola, C. (2005). Interaction of porphyrin with G-quadruplex structures. Nucleosides, Nucleotides, and Nucleic Acids. 24 , 753-6.

Ahmed, Z., Beeton, C. A., Williams, M. A., Clements, D., Baldari, C. T., & Ladbury, J. E. (2005). Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T cell receptors. Journal of Molecular Biology. 353 , 1001-1010.

Keatch, S. A., Leonard, P. G., Ladbury, J. E., & Dryer, D. T. F. (2005). StpA protein from E.coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNaseI and EcoKI. Nucleic Acids Research. 33 , 6540-6546.


Dr Philip Lowden [top]

Emma Hockly, Jamie Tse, Amy L. Barker, Donna L. Smith, Jean-Luc Beunard, Adrian P. Revington, Kim Holt, Sunny Sunshine, Hilary McPhail, Kirupa Sathasivam, Ben  Woodman, Erich E. Wanker, Philip A.S. Lowden, Gillian P. Bates (2005). Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease Neurobiology of Disease. In press.

Dr Charles Marson [top]

A. J. A. Cobb and C. M. Marson (2005). Asymmetric Synthesis using Catalysts containing Multiple Stereogenic Centres and a trans-1,2-Diaminocyclohexane Core; Reversal of Predominant Enantioselectivity upon N-Alkylation. Tetrahedron 2005, 61, 1269-1279

C. M. Marson and R. C. Melling (2005). Enantioselective  Syntheses of trans-3,4-Difluoropyrrolidines and Investigation of their Applications in Catalytic Asymmetric Synthesis. J. Org. Chem. 2005, 70, accepted.

C. M. Marson and R. C. Melling (2005). Syntheses of Enantiopure 3,4-Diamino-1-Substituted Pyrrolidines. Synthesis 2005, accepted.

C. M. Marson, R. C. Melling, S. J. Coles and M. B. Hursthouse (2005), 16,  accepted  .  . Synthesis of (3S,3S',4S,4S')-1,1'-Ethylenedipyrrolidine-3,3',4,4'-tetraol and related Diamino Diols: Donor-Acceptor Hydrogen-Bonding Motifs of the C2 Symmetric 3,4-Dihydroxypyrrolidine Unit. Tetrahedron: Asymmetry

Dr Andrew Martin [top]

Not yet available

Dr Nigel Martin [top]

M Maibaum, L Zamboulis, G Rimon, C.Orengo, N Martin, A.Poulovasillis (2005). Cluster Based Integration of Heteregeneous Biological Databases Using the AutoMed toolkit. Proceedings 2nd Int. Workshop on Data Integration in the Life Sciences DILS 2005. pp 191-207.

Dr Neil McDonald [top]

Laman H, Funes JM, Ye H, Galinanes-Garcia L, Hara E, Knowles PP, McDonald NQ & Boshoff C. (2005). Novel oncogenic activity of Fbx7 is mediated by regulation of cyclin D/cdk6. EMBO Journal. 24: 3104-3116.

Newman M, Murray-Rust J, Lally J, Rudolf J, Fadden A, Knowles PP, White MF, McDonald NQ. (2005). Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition. EMBO Journal. 24; 895-905

Nicastro G, Menon RP, Masino L, Knowles PP, McDonald NQ, Pastore A. (2005). The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition. Proc. Natl. Acad. Sci.102(30):10493-8.

Professor Boris Mirkin [top]

Pampapathi R., Mirkin B., Levene M. (2005). A Suffix Tree Approach to Text Categorisation Applied to Email Filtering, Proceedings UK Workshop on Computational Intelligence, Birkbeck College London. pp 212-219.

Makarova KS, Wolf YI, Mekhedov SL, Mirkin BG, Koonin EV. (2005). Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell. Nucleic Acids Research. 33(14):4626-38.

Mirkin B. (2005). Clustering for Data Mining: A Data Recovery Approach. Boca Raton Fl., Chapman and Hall/CRC. 276 p.

Wasito I, Mirkin B. (2005). Nearest neighbour approach in the least squares data imputation algorithms. Information Sciences. 169, 1-25.

Dr Carolyn Moores [top]

Not yet available

Professor David Moss [top]

Not yet available

Dr Sylvia Nagl [top]

Kumar, S., Nagl, S., Kalsi, J. K., Ravirajan, C. T., Athwal, D., Latchman, D. S., Pearl, L. H., and Isenberg, D. (2005). A.Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: a novel mechanism for acquisition of cross-eactivity by an autoantibody. Molecular Immunology 42:39-48.

Nagl, S. (2005). Vertical genomics and the dynamics of cell signaling. Screening May:26-28.

Professor Christine Orengo [top]

P Kellam, S. Swift, A. Tucker, V. Vinciotti, N. Martin, C. Orengo, & X. Liu. (2005). Consensus clustering and functional interpretation of gene expression Data.  Genome Research. In Press.

D. Lee, A. Grant, R. Marsden and C. Orengo (2005). Identification and Distribution of Protein Families in 120 Completed Genomes using Gene3D.  Proteins: Structure, Function and Genetics Vol 59:603-15.

C. Orengo & J. Thornton. (2005). Proteins  Families and Their Evolution - A Structural Perspective.  Annual Review of Biochemistry. Vol 74:867-900

Pearl F, Todd A, Sillitoe I, Dibley M, Redfern O, Lewis T, Bennett C, Marsden R, Grant A, Lee D, Akpor A, Maibaum M, Harrison A, Dallman T, Reeves G, Diboun I, Addou S, Lise S, Johnston C, Sillero A, Thornton J, Orengo C.. The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis.  Nucleic Acids Research Vol 33:D247-51.

J. Ranea, D. Buchan, J. Thornton, & C. Orengo. (2005). Microeconomic principles explain an optimal genome size in bacteria.  Trends in Genetics. Vol 21:21-5.

Redfern O, Grant A, Maibaum M, Orengo C. J (2005). Survey of current protein family databases and their application in comparative, structural and functional genomics.  Chromatogr B Analyt Technol Biomed Life Sci. ( 2005) Vol 815:97-107.

I. Sillitoe, M. Dibley, J. Bray, S. Addou & Christine Orengo (2005). Assessing Strategies For Improved Superfamily Recognition in Genome Annotation   Protein Science. Vol 14:1800-10

Todd AE, Marsden RL, Thornton JM, Orengo CA (2005). Progress of structural genomics initiatives: an analysis of solved target structures. J Mol Biol. Vol 348:1235-60.

Dr Elena Orlova [top]

Tilley SJ, Orlova EV, Gilbert RJ, Andrew PW, Saibil HR. (2005) Structural basis of pore formation by the bacterial toxin pneumolysin. Cell. 121(2):247-56.

Kennaway CK, Benesch JL, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR, Keep NH. (2005). Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis.J Biol. Chem. 280 , 33419-33425.

Professor Steve Perkins [top]

Gilbert, H. E., Eaton, J. T., Hannan, J. P., Holers, V. M., and Perkins, S. J. (2005) Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study. J. Mol. Biol. 346, 859-873.

O'Connell, N. M., Saunders, R. E., Lee, C. A., Perry, D. J. and Perkins, S. J. (2005) Structural interpretation of 42 mutations causing factor XI deficiency using homology modeling. J. Thromb. Haemost. 3, 127-138.

Perkins, S. J. & Furtado, P. B. (2005). Invited review. Complement and immunoglobulin protein structures by X-ray and neutron solution scattering and analytical ultracentrifugation. Structural Biology of the Complement System (Eds: Dimitrios Morikis and John D. Lambris), Chapter 13, pp 293-315. Publisher: Taylor and Francis, Boca Raton, USA.

Hu, Y., Sun, Z., Eaton, J. T., Bouloux, P. M. G. & Perkins, S. J. (2005) Extended domain solution structure of the extracellular matrix protein anosmin-1 by X-ray scattering, analytical ultracentrifugation and constrained modeling. J. Mol. Biol. 350, 553-570.

Perkins, S. J., Gilbert, H. E., Lee, Y. C., Sun, Z. & Furtado, P. B. (2005) Invited review. Relating small angle scattering and analytical ultracentrifugation in multidomain proteins. In "Modern Analytical Ultracentrifugation: Techniques and Methods" eds. Scott, D. J., Harding S. E. & Rowe A. J. Royal Society of Chemistry, London, UK. Chapter 15, pp 291-319. ISBN: 0854045473.

Saunders, R. E., O'Connell, N. M., Lee, C. A., Perry, D. J. & Perkins, S. J. (2005). The factor XI deficiency database: an interactive web database of mutations, phenotypes and structural analysis tools. Human Mutation, 26, 192-198.

Sun, Z., Almogren, A., Furtado, P. B., Chowdhury, B., Kerr, M. A. & Perkins, S. J. (2005). Semi-extended solution structure of human myeloma immunoglobulin D determined by constrained X-ray scattering. J. Mol. Biol. 353, 155-173.

von Ossowski, I., Eaton, J. T., Czjzek, M., Perkins, S. J., Frandsen, T. P., Schülein, M., Panine, P., Henrissat, B. and Receveur-Bréchot, V. (2005) . Protein disorder: conformational distribution of the flexible linker in a chimeric double cellulase. Biophys. J. 88 , 2823-2832.


Professor Peter Rich [top]

Ingledew W.J. and Rich P.R. (2005). A study of the horseradish peroxidase catalytic cycle by FTIR spectroscopy. Biochemical Society Transactions.   33, 886-889.

Ingledew W.J., Smith S.M.E., Gao Y.T., Jones R.J., Salerno J.C. and Rich P.R. (2005). Ligand, co-factor and residue vibrations in the catalytic site of endothelial Nitric Oxide Synthase. Biochemistry. 44, 4238-4246.

Iwaki M., Yakovlev G., Hirst J., Osyczka A., Dutton P.L., Marshall M. and Rich P.R. (2005). Direct observation of redox-linked histidine protonation changes in the iron sulfur protein of cytochrome bc1 complex by ATR-FTIR spectroscopy. Biochemistry . 44, 4230-4237.

Rich P.R. and Iwaki M. (2005). Infrared Protein Spectroscopy as a Tool to Study Protonation Reactions Within Proteins. In 'Biophysical and Structural Aspects of Bioenergetics' (Wikstrom M. ed.). Chapter 13, pp. 314  333, Royal Society of Chemistry, Cambridge, UK.

van Thor J.J., Fisher N. and Rich P.R. (2005) . Assignments of the Pfr-Pr FTIR difference spectrum of cyanobacterial phytochrome Cph1 using a 15N and 13C isotopically labelled phycocyanobilin chromophore J. Phys. Chem. 20597-20604.

Professor David Saggerson [top]

Not yet available

Professor Helen Saibil [top]

Kennaway CK, Benesch JLP, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR and Keep NH. (2005). Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J.Biol. Chem. 280 , 33419-33425.

Gohlke U, Pullan L, McDevitt CA, Porcelli I, de Leeuw E, Palmer T, Saibil HR, Berks BC (2005). The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter.  Proc. Natl. Acad. Sci.  102, 10482-104866.

S.J. Tilley, E.V. Orlova, R.J.C. Gilbert, P.W. Andrew & H.R. Saibil (2005). Structural basis of pore formation by the bacterial toxin pneumolysin.  Cell. 121, 247-256.

Dr Renos Savva [top]


Dr David Selwood

Not yet available

Professor Elizabeth Shephard [top]

Not yet available

Dr Adrian Shepherd

Not yet available

Dr Christine Slingsby [top]

Fan J, Fariss RN, Purkiss AG, Slingsby C, Sandilands A, Quinlan R, Wistow G & Chepelinsky A. (2005) . Specific interaction between lens MIP/Aquaporin-0 and two members of the beta/gamma-crystallin family. Molecular Vision. 11, 76-87.

MacDonald JT, Purkiss AG, Smith MA, Evans P, Goodfellow JM& Slingsby C. (2005) . Unfolding crystallins: the destabilising role of a beta-hairpin cysteine in betaB2-crystallin by simulation and experiment.  Protein Science. 14, 1282-1292.

Shimeld SM, Purkiss AG, Dirks RPH, Bateman OA, Slingsby C & Lubsen NH (2005) . Urochordate beta/gamma-crystallin and the evolutionary origin of the vertebrate eye lens.  Current Biology. 15: 1684-1689.

Stamler R, Kappe G, Boelens W & Slingsby C. (2005). Wrapping the alpha-crystallin domain fold in a chaperone assembly.  Journal of Molecular Biology. 353: 68-79.

Wistow G, Wyatt K, David L, Gao C, Bateman O, Bernstein S, Tomarev S, Segovia L, Slingsby C & Vihtelic T. (2005) . GammaN-crystallin and the evolution of the beta/gamma-crystallin superfamily in vertebrates.  FEBS Journal 272, 2276-2291.

Dr Alethia Tabor

S. Bregant, A. B. Tabor. Orthogonally Protected Lanthionines: Synthesis and Use for the Solid-Phase Synthesis of an Analogue of Nisin Ring C J. Org.Chem 70, 2430 –2438

B. M. Chain, P. F. Free, P. Medd, C. Swetman, A. B. Tabor, N. Terrazzini (2005). The expression and function of cathepsin E in dendritic cells J. Immunol 174, 1791-1800

S. Sarkar, L. K. Lee, S. L. Hart, H. C. Hailes, S. M.  Levy, A. B. Tabor, P. Ayazi Shamlou (2005). Fractal Structure of Polycation-DNA Complexes Biotech. Appl. Biochem 41, 127-136

Professor Gabriel Waksman

M. Duckely, C. Oomen, F. Axthelm, P. Van Gelder, G. Waksman, and A. Engel* (2005). The VirE1VirE2 complex of Agrobacterium tumefaciens interacts with ssDNA and forms channels. Mol. Microbiol. 58:1130-1142.

O.Y. Lubman, R. Kopan, G. Waksman, and S. Korolev* (2005). The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein Science. 14:1274-1281.

P.J. Rothwell, V. Mitaksov, and G. Waksman* (2005). Motions of the fingers subdomain of the Klentaq1 DNA polymerase I enzyme are fast and not rate-limiting: implications for the molecular basis of fidelity in DNA polymerases. Molecular Cell. 19:345-355.

P.J. Rothwell and G. Waksman* (2005). Structure and mechanism of DNA polymerases. Advances in Protein Chemistry. 71:401-440

F.G. Sauer, S.J. Hultgren, and G. Waksman* (2005). The chaperone-usher pathway of pilus fiber biogenesis. In: Structural Biology of Bacterial Pathogensis. ASM Press, G.Waksman, M. Caparon and S. Hultgren (Eds). pp 69-80.

G. Schroder, S.N. Savvides, G. Waksman, and E. Lanka* (2005). The type IV secretion machinery. In: Structural Biology of Bacterial Pathogensis. ASM Press, G.Waksman, M. Caparon and S. Hultgren (Eds). pp179-222.

C.L. Smith, K. Dodson, G. Waksman, and S.J. Hultgren* (2005). Sugar recognition and bacterial attachment. In: Structural Biology of Bacterial Pathogensis. ASM Press, G.Waksman, M. Caparon and S. Hultgren (Eds). pp37-48.

N.K. Surana, S.E. Cotter, H-J. Yeo, G. Waksman, J. St Gemes* (2005). Structural determinants of Haemophilus influenzae adherence to host epithelium: Variations on type V secretion. In: Structural Biology of Bacterial Pathogensis. ASM Press, G.Waksman, M. Caparon and S. Hultgren (Eds). pp129-148.

L. Terradot, R. Bayliss, C. Oomen, G. Leonard, and G. Waksman* (2005). Structures of two core subunits of the type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori. Proceedings of the National Academy of Sciences (USA). 102:4596-4601.

G. Waksman* and C. Sansom (2005). Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, And Drug Design. In: Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, And Drug Design. Kluwer Press. G. Waksman (Ed). In Press.

G, Waksman* (2005). Structural biology of protein complexes. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. Wiley Ed.

Professor Bonnie Wallace [top]

Cronin, N.B., O'Reilly, A., Duclohier, H., and Wallace, B.A. (2005). Effects of Deglycosylation of Sodium Channels on their Structure and Function. Biochemistry. 44:441-449.

Miles, A.J., Whitmore, L., and Wallace, B.A. (2005). Spectral Magnitude Effects on the Analyses of Secondary Structure from Circular Dichroism Spectroscopic Data. Protein Science. 14:368-374.

Miles, A.J., Wien, F., Lees, J.G., and Wallace, B.A. (2005). Calibration and Standardisation of Synchrotron Radiation and Conventional Circular Dichroism Spectrometers. Part 2: Factors Affecting Magnitude and Wavelength. Spectroscopy. 19:43-51.

Miles, A.J., Sansom, C.E., and Wallace, B.A. (2005). Protein Structure and Classification. In: Essays in Bioinformatics (Moss, D. S., Jelaska, S. and Pongor, S.eds.), NATO Science Series: Live and Behavioural Sciences, Vol. 368. IOS Press,Amsterdam-Berlin-Oxford-Tokyo-Washington DC.

Wallace, B.A. (2005). Shining New Light on Protein Structure and Function thru Synchrotron Radiation Circular Dichroism (SRCD) Spectroscopy. Australian Biochemist. 36: 47-50.

Wallace, B.A. and Janes, R.W. (2005). International Workshop on the Protein Circular Dichroism Data Bank. Synchrotron Radiation News. 18: 20-21.

Wien, F., and Wallace, B.A. (2005) Calcium Fluoride Micro Cells for Synchrotron Radiation Circular Dichroism Spectroscopy. Appl. Spectroscopy. 59:1109-1113.

Wien, F., Miles, A.J., Lees, J.G., Hoffman, S. Vronning, and Wallace, B.A. (2005). VUV Irradiation Effects on Proteins in High Flux Synchrotron Radiation Circular Dichroism (SRCD) Spectroscopy. J. Synch. Radiation. 12: 517-523.


Dr Lorenz Wernisch [top]

M. dos Reis, R. Savva, L. Wernisch (2005). Solving the riddle of codon usage preferences: a test for translational selection Nucleic Acids Research

N. Domedel-Puig and L. Wernisch (2005). GIFT: a Gene Interactions Finder in Text. Bioin- formatics. 21(17):3582-3.

M. T. Edwards, S. C. Rison, N. G. Stoker, and L. Wernisch (2005). A universally applicable method of operon map prediction on minimally annotated genomes using conserved genomic context Nucleic Acids Research. 33(10):3253-66.



Institute of Structural Molecular Biology, University of London
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