The Waksman Lab

Welcome to the Waksman lab’s website! We work on the Structural and Molecular Biology of secretion systems in bacteria. Secretion systems are important virulence factors in pathogenic bacteria and also play essential roles in bacterial survival, adaptation, and evolution. We focus mostly on two secretion systems i) the Type IV Secretion (T4S) systems, and ii) specialised assembly and secretion machines involved in pilus biogenesis. These systems form large nanomachines embedded in the bacterial membranes. Our goal is to understand how these machines work. To do so, we use a multi-disciplinary approach combining structural (electron microscopy, X-ray crystallography), molecular (cloning, tagging), biophysical (mass spectrometry, EPR, FRET, etc.) and cell biological (fluorescence microscopy) techniques. Click on the links below to learn a little bit more about the systems we study. T4S systems Pilus biogenesis
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News highlights

New publication in Nature Structure of a type IV secretion system Professor Gabriel Waksman elected to the German National Academy of Sciences in recognition of his research into the structural and molecular biology of secretion systems in bacteria New T4SS review ‘Recent advances in the structural and molecular biology of type IV secretion systems’
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