The Waksman Lab

Welcome to the Waksman lab’s website! We work on the Structural and Molecular Biology of secretion systems in bacteria. Secretion systems are important virulence factors in pathogenic bacteria and also play essential roles in bacterial survival, adaptation, and evolution. We focus mostly on two secretion systems i) the Type IV Secretion (T4S) systems, and ii) specialised assembly and secretion machines involved in pilus biogenesis. These systems form large nanomachines embedded in the bacterial membranes. Our goal is to understand how these machines work. To do so, we use a multi-disciplinary approach combining structural (electron microscopy, X-ray crystallography), molecular (cloning, tagging), biophysical (mass spectrometry, EPR, FRET, etc.) and cell biological (fluorescence microscopy) techniques. Click on the links below to learn a little bit more about the systems we study. T4S systems Pilus biogenesis
Waksman Lab Homepage Research People Publications Movies and Images About Professor Gabriel Waksman Contact
News highlights New publication in Nature  Structure and energetic basis of folded protein transport by the FimD usher New ERC Advanced Grant 'Structural biology of Legionella’s Effectors and Secretion System’ 15th Rodney Porter Memorial Lecture 2013 University of Oxford  ‘Structural and molecular biology of bacterial secretion systems’
Waksman Lab Homepage