Publications

Professor Bart Hoogenboom’s group publish paper in ACS Nano

Professor Bart Hoogenboom’s research group published a paper titled ‘Quantification of Biomolecular Dynamics inside Real and Synthetic Nuclear Pore Complexes using Time-Resolved Atomic Force Microscopy’ in ACS Nano in June 2019.

The full paper is available here.

Posted by ublmcr01 in News, Publications, Uncategorised

Studying protein conformation using a new cyclic ion mobility mass spectrometry (cIMMS) device

Dr Konstantinos Thalassinos

We are the first group to publish a paper on how a new cyclic ion-mobility mass-spectrometry (cIMMS) device, manufactured by Waters, can be used to probe protein structure and dynamics. In particular, the tandem ion mobility capabilities of the instrument allow us to probe in very fine detail protein unfolding pathways and for the first time to do so for co-existing and interconverting conformers. We are now using this technology to study proteins involved in protein misfolding diseases such as human amyloid islet polypeptide.

The paper is:
Eldrid, C.; Ujma, J.; Kalfas, S.; Tomczyk, N.; Giles, K.; Morris, M.; Thalassinos, K. Gas Phase Stability of Protein Ions in a Cyclic Ion Mobility Spectrometry Traveling Wave Device. Anal. Chem. 2019, 91 (12), 7554–7561 https://doi.org/10.1021/acs.analchem.8b05641

A video where I and other people in the field describe the cIMMS technology:
https://vimeo.com/318178536/005117727e

The link to the Waters site:
https://www.waters.com/waters/en_US/SELECT-SERIES-Cyclic-IMS-ion-mobility-mass-spectrometer/nav.htm?cid=135021297&locale=en_PT

 

Posted by ublmcr01 in Lab news, News, Publications, Uncategorised

Research by the Hansen group featured in ChemPhysChem

Research presenting a new method for probing solution‐state interactions of arginine side‐chains in proteins by Prof Flemming Hansen and 3rd year Hansen group PhD student Harry MacKenzie was featured as the cover article for the February 2019 European Journal of Chemical Physics and Physical Chemistry.

Full paper: Arginine Side‐Chain Hydrogen Exchange: Quantifying Arginine Side‐Chain Interactions in Solution

Feature profile

Cover illustration

Prof Flemming Hansen

 

 

 

 

 

Posted by ubcg49z in News, Publications, Student news

New, giant bacterial virus found in human gut

A new giant virus that infects bacteria commonly found in the human gut has been discovered by an international team led by researchers from UCL including Professor Joanne Santini, and UC Berkeley.

The new ‘megaphage’ called ‘Lak’ is the same size as some bacteria and is the biggest ever reported phage found in the human gut.

A study published in Nature Microbiology describes the discovery of Lak phage and reports that they specifically infect bacteria called Prevotella, which live in all people but most notably those who have a diet high in fibre and low in fat.

Prevotella is also associated with upper respiratory tract infections and is prevalent in periodontal disease, which means the new megaphage may open up the development of new phage-based treatments for infections caused by Prevotella.

Research paper in Nature Microbiology

UCL News commentary

Professor Joanne Santini

 

Posted by ubcg49z in News, Publications